Results 101 to 110 of about 103,750,445 (281)

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Prognostic impact of insulin‐like growth factor‐I and its binding proteins, insulin‐like growth factor‐I binding protein‐2 and ‐3, on adverse histopathological features and survival outcomes after radical cystectomy

, 2022
OBJECTIVES: Insulin‐like growth factor‐I and its binding proteins are involved in cancer development, progression, and metastasis. In urothelial carcinoma, the impact of this pathway is still poorly investigated.
Satoshi Katayama, Grossmann, Nico C., Katayama, Satoshi, Mori, Keiichiro, Mostafai, Hadi, Richard Lee, Sari Motlagh, Reza, Comprate, Eva, Victor M Schuettfort, Pierre I Karakiewicz, Pawel Rajwa, Fahad Quhal, Keiichiro Mori, Rajwa, Pawel, Abdulmajeed Aydh, Laukhtina, Ekaterina, Shahrokh F Shariat, Benjamin Pradere, Schuettfort, Victor M, Abufaraj, Mohammad, Gontero, Paolo, Nico C Grossmann, Mohammad Abufaraj, Yair Lotan, Shariat, Shahrokh F., Quhal, Fahad, Lee, Richard, Shariat, Shahrokh F, Ekaterina Laukhtina, Karakiewicz, Pierre I., Aydh, Abdulmajeed, Karakiewicz, Pierre I, Lotan, Yair, Grossmann, Nico C, Reza Sari Motlagh, Eva Comprate, Moschini, Marco, Paolo Gontero, Pradere, Benjamin, Marco Moschini, Hadi Mostafai, Schuettfort, Victor M.   +41 more
core   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk [PDF]

, 2010
Drosophila Lnk is the single ancestral orthologue of a highly conserved family of structurally-related intracellular adaptor proteins, the SH2B proteins.
Linda Partridge, Partridge, L., Withers, D., Stocker, H, Withers, D.J., Foley, A., Foley, Andrea, Hafen, Ernst, Cathy Slack, Thornton, Janet M., Werz, C, Wieser, D, Stocker, Hugo, Thornton, J., Slack, C, Wieser, D., Werz, C., Hafen, E, Withers, Dominic J., Hafen, E., Lu, Bingwei, Dominic J Withers, Nazif Alic, Janet M Thornton, Werz, Christian, Alic, N, Stocker, H., Withers, DJ, Ernst Hafen, Partridge, Linda, Slack, Cathy, Hugo Stocker, Andrea Foley, Wieser, Daniela, Foley, A, Alic, Nazif, Partridge, L, Christian Werz, Thornton, JM, Alic, N., Daniela Wieser, Slack, C., Lu, B., Thornton, J. M.   +43 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Linear growth failure induced by systemic inflammation inhibiting IGF-1/IGFBP axis in rats with asymptomatic colitis

BMC Gastroenterology, 2019
Background Children in poor areas show significant growth retardation that does not improve with an adequate supply of energy and nutrients, which may be related to asymptomatic intestinal infection caused by poor sanitation. Our objective was to explore
Xiaoyang Sheng, Xueqing Sun, Feng Li, Junli Wang, Jingqiu Ma   +4 more
doaj   +1 more source

Analysis of serum levels of anti-Mullerian hormone, inhibin B, insulin-like growth factor-I, insulin-like growth factor binding protein-3, and follicle-stimulating hormone with respect to age and menopausal status [PDF]

, 2008
Analysis of serum levels of anti-Mullerian hormone, inhibin B, insulin-like growth factor-I, insulin-like growth factor binding protein-3, and follicle-stimulating hormone with respect to age and menopausal ...
Gyung Woon Noh, Kang, Won Jun, Won Jun Kang, Chung, June-Key, Jung Ryeol Lee, Hyun Joo Kim, Noh, Gyung Woon, Seok Hyun Kim, Lee, Jung Ryeol, Kim, Hyun Joo, June-Key Chung, Kim, Seok Hyun, Sun Young Shin, 강원준, Shin, Sun Young   +14 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Research progress of IGF-1 and IGFBP-3 in type 2 diabetes and its microvascular complications

生物医学转化
The prevalence of type 2 diabetes mellitus (T2DM) and its microvascular complications is increasing year by year, posing a serious threat to human health and greatly increasing the socioeconomic burden.
Huang Shuting, Yang Yang
doaj   +1 more source