Fasting Induces Gene Expression of Insulin-like Growth Factor-binding Proteins in Skeletal Muscles of Chicks [PDF]
The Journal of Poultry ScienceIn mammals, evidence suggests that insulin-like growth factor-binding proteins (IGFBPs) affect skeletal muscle growth in an autocrine and paracrine manner.
Asmaa S. El-far +4 more
doaj +2 more sources
Associations of serum C-peptide and insulin-like growth factor binding proteins-3 with breast cancer deaths. [PDF]
PLoS ONE, 2020 C-peptide is usually considered as a marker of insulin secretion and has no physiological function. This study aimed to assess the association between serum C-peptide level as independent risk factor and breast cancer and explored the possible underlying
PinYu Cui +5 more
doaj +2 more sources
Insulin-Like Growth Factor Binding Proteins and IGFBP Proteases: A Dynamic System Regulating the Ovarian Folliculogenesis [PDF]
Frontiers in Endocrinology, 2018 The aim of the present article is to update our understanding of the expression of the insulin-like growth factor binding proteins (IGFBPs), IGFBP proteases and their implication in the different processes of ovarian folliculogenesis in mammals.
Sabine Mazerbourg, Philippe Monget
doaj +2 more sources
Insulin-Like Growth Factors, Binding Proteins and Their Role in Pregnancy in Patients With Diabetes [PDF]
Journal of Diabetes ResearchThe insulin-like growth factor (IGF) axis, an evolutionarily conserved system, is critical in regulating cell growth, proliferation, and survival, affecting nearly all organ systems.
Aleksandra Gladych-Macioszek +5 more
doaj +2 more sources
Insulin-like growth factors: Ligands, binding proteins, and receptors
Molecular Metabolism, 2021 Background: The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin), receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1-6) play critical roles in normal human physiology and disease states.
Derek LeRoith +2 more
doaj +1 more source
Transferrin binds insulin‐like growth factors and affects binding properties of insulin‐like growth factor binding protein‐3 [PDF]
FEBS Letters, 2001 In the circulation, most of the insulin‐like growth factors (IGFs) are bound to a ternary 150 kDa complex with IGF‐binding protein (IGFBP)‐3 and the acid labile subunit. In the current study, we identify transferrin (Tf) by mass spectrometry, and immunoprecipitation as a component of a major IGF‐binding fraction separated from human plasma.
Storch, S. +6 more
openaire +3 more sources
Thermal stress impaired expression of insulin-like growth factor binding proteins in pigs
Indian Journal of Animal Sciences, 2023 This study aimed to investigate the correlation of IGFs, IGFBPs, and IGFBPRs of grower pigs with change in temperature humidity index (THI). THI was calculated to know the months of the year when pigs feel discomfort and samples of feed offered were ...
S BORAH +8 more
doaj +1 more source
Animals, 2022 The relevance of the insulin-like growth factor-1 (IGF-1) system in several physiological processes is well-known in vertebrates, although little information about their temporal organization is available.
Aitana Alonso-Gómez +4 more
doaj +1 more source
Proteolysis of insulin-like growth factor binding proteins (IGFBPs) by calpain [PDF]
, 2005 Calpains are non-lysosomal, Ca2+-dependent cysteine proteases, which are ubiquitously distributed across cell types and vertebrate species. The rules that govern calpain specificity have not yet been determined.
Andress +15 more
core +1 more source
Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis [PDF]
, 2012 Extracellular matrix deposition and tissue scarring characterize the process of fibrosis. Transforming growth factor beta (TGFβ) and Insulin-like growth factor binding protein-3 (IGFBP-3) have been implicated in the pathogenesis of fibrosis in various ...
Adriana T. Larregina +7 more
core +9 more sources