Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits [PDF]
, 2016 The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including ...
Aschard, H. (Hugues) +85 more
core +1 more source
Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation [PDF]
, 2016 Experimental results for the determination of internalization rates for IGF1-IGF1R, IGF2-IGF1R, IGF2-IGF2R.
Dan Tian +2 more
core +5 more sources
CDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins [PDF]
, 1994 The insulin-like growth factor binding proteins (IGFBPs) comprise a family of six distinct proteins which modulate insulin-like growth factor action. We have isolated cDNAs encoding the six mouse IGFBPs (mIGFBPs).
Drop, S.L.S. (Stenvert) +4 more
core +2 more sources
Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2015 Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the local IGF-I-IGFBPs environment in response
Min Sun Kim, Dae-Yeol Lee
doaj +1 more source
Obesity and breast cancer in premenopausal women: Current evidence and future perspectives [PDF]
, 2018 There is raising evidence reporting an increased incidence of breast cancer over the past decades. Every year approximately 1.4 million new cases of breast cancer are diagnosed worldwide, with a mortality rate of approximately 450,000/year.
Barrea, Luigi +4 more
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Animal insulin-like growth factor binding proteins and their biological functions
Veterinární Medicína, 2002 Insulin-like growth factor (IGF-I, IGF-II) action is influenced by until today known eight forms of insulin-like growth factor binding proteins (IGFBPs).
Z. Kostecká, J. Blahovec
doaj +1 more source
Technology in Cancer Research & Treatment, 2020 RNA-binding proteins have been associated with cancer development. The overexpression of a well-known RNA-binding protein, insulin-like growth factor 2 messenger RNA–binding protein 3, has been identified as an indicator of poor prognosis in patients ...
Jing Zhang MS +4 more
doaj +1 more source
Late Effects of Disturbed IGF Signaling in Congenital Diseases. [PDF]
, 2007 The biologic effects of insulin-like growth factor-1 (IGF-1) are mediated by specific cell surface receptors. IGF-1 binding to the extracellular -subunits activates the tyrosine kinase intrinsic to the cytoplasmic portion of the IGF-1 receptor ...
Cianfarani S +4 more
core +1 more source
Customized biomaterials to augment chondrocyte gene therapy [PDF]
, 2017 A persistent challenge in enhancing gene therapy is the transient availability of the target gene product. This is particularly true in tissue engineering applications.
Aguilar, Izath Nizeet +3 more
core +1 more source
Advanced Biomedical Research, 2015 Background: The effect of the growth hormone on target cells is mediated by the insulin-like growth factor 1 (IGF-1). IGF-1 binds to the insulin-like growth factor binding proteins (IGFBPs) in blood and biological fluids.
Emad Khodadadi +4 more
doaj +1 more source