Results 151 to 160 of about 90,101 (333)

Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid

Nature Communications, 2018
Toxic gain-of-function by islet amyloid polypeptide (IAPP) is thought to be mediated by membrane poration. Here the authors develop diluted-FRET to show that changes in pore structure correlate with onset of toxicity inside insulin secreting cells.
Melissa Birol, Sunil Kumar, Elizabeth Rhoades, Andrew D. Miranker   +3 more
doaj   +1 more source

Up‐regulation of L‐ and non‐L, non‐N‐type Ca²⁺ channels by basal and stimulated protein kinase C activation in insulin‐secreting RINm5F cells [PDF]

, 1996
Daniela Platano, Antonella Pollo, Emilio Carbone, Giorgio Aicardi   +3 more
openalex   +1 more source

Biomimetic Cell Membrane‐Coated Scaffolds for Enhanced Tissue Regeneration

Advanced Materials, EarlyView.
This review examines the development and use of cell membrane‐coated scaffolds in tissue engineering. Bioinspired phospholipid and glycocalyx coatings enhance anti‐fouling, anti‐thrombogenic, and selective molecular recognition properties. Native cell membrane coatings further support cell‐specific interactions, immune modulation, and reduced bacterial
Carmen Alvarez‐Lorenzo, Alejandro Ramirez‐Romero, Diana Peixoto, Maria Vivero‐Lopez, Isabel Rodríguez‐Moldes, Angel Concheiro   +5 more
wiley   +1 more source

Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons

Nature Communications, 2019
Glucagon-like peptide 1 (GLP-1) is released from intestinal L-cells following nutrient uptake and enhances insulin release as well as promotes satiety. Here, the authors demonstrate that GLP-1 secreting cells release ATP and that this stimulates nodose ...
Van B. Lu, Juraj Rievaj, Elisabeth A. O’Flaherty, Christopher A. Smith, Ramona Pais, Luke A. Pattison, Gwen Tolhurst, Andrew B. Leiter, David C. Bulmer, Fiona M. Gribble, Frank Reimann   +10 more
doaj   +1 more source

Subcellular Distribution and Function of Rab3A, B, C, and D Isoforms in Insulin-Secreting Cells [PDF]

, 1999
Mariella Iezzi, Gérard Escher, Paolo Meda, Anne Charollais, Giulia Baldini, François Darchen, Claes B. Wollheim, Romano Regazzi   +7 more
openalex   +1 more source

Zinc‐Coordinated Trienzyme Nanogel Cascade Therapy for Accelerated Post‐Pancreatectomy Cutaneous Wound Healing

Advanced Materials, EarlyView.
A zinc‐coordinated nanogel assembly is reported that co‐delivers three enzymes to regulate glucose, oxidative stress, and oxygen levels. This system mimics natural enzyme cascades to reprogram the wound environment after pancreatectomy. In a post‐pancreatectomy mouse model, it accelerates healing by reducing infection, promoting blood vessel growth ...
Yedong Ma, Chengke Xie, Chengyu Liao, Binting Huang, Siqi Liu, Junhua Kong, Xiaotong Fan, Zibiao Li, Shi Chen, Chaobin He   +9 more
wiley   +1 more source

Ceramide‐activated protein phosphatase‐2A activity in insulin‐secreting cells [PDF]

, 1997
Anjaneyulu Kowluru, Stewart A. Metz
openalex   +1 more source

Nanostructured Protein Surfaces Inspired by Spider Silk

Advanced Materials, EarlyView.
Harnessing recombinant spider silk technology, bioengineered spidroin variants enable the creation of functionalized nanostructured coatings with tunable affinity for specific targets, supporting a broad range of applications ‐ from antifouling surfaces and targeted drug delivery to advanced cell therapies and precision bio‐patterning via lithography ...
Martin Humenik, Thomas Scheibel
wiley   +1 more source

Liquiritin Exerts a Dual Effect on BMSCs Osteogenic Differentiation and Fracture Healing by Activating the ERK/JNK Pathway and Providing Antioxidant Protection

Advanced Therapeutics, EarlyView.
Liquiritin enhances the osteogenic differentiation of BMSCs and promotes fracture healing through the activation of the ERK/JNK signaling pathway and by exerting antioxidant protective effects. Abstract Liquiritin, a flavonoid from Glycyrrhiza uralensis L., has diverse pharmacological properties, but its impact on fracture healing is unexplored.
Haijun Mao, Jing Liu, Juan Feng, Yalikun Yusufu, Lei Yang, Qing Jiang, Minghui Sun   +6 more
wiley   +1 more source

Effect of estradiol on insulin secreting INS-1 cells overexpressing estrogen receptors [PDF]

, 2000
PA Horn, Matthias Möhlig, Martin Osterhoff, Sabine Wolter, Johanna Hofmann, Carol Stocking, Wolfram Ostertag, Martin Wahl, H. Schatz, A. Pfeiffer   +9 more
openalex   +1 more source