Results 11 to 20 of about 1,054,549 (287)

Use of the SGLT2 inhibitor canagliflozin for control of refractory equine hyperinsulinemia and laminitis [PDF]

Open Veterinary Journal, 2022
Background: Hyperinsulinemia associated with pituitary pars intermedia dysfunction (PPID) and/or equine metabolic syndrome (EMS) is well documented to put horses at high risk of laminitis.
Eleanor M. Kellon, Kathleen M. Gustafson
doaj   +1 more source

Molecular and Cellular Bases of Lipodystrophy Syndromes

Frontiers in Endocrinology, 2022
Lipodystrophy syndromes are rare diseases originating from a generalized or partial loss of adipose tissue. Adipose tissue dysfunction results from heterogeneous genetic or acquired causes, but leads to similar metabolic complications with insulin ...
Jamila Zammouri, Camille Vatier, Camille Vatier, Emilie Capel, Martine Auclair, Caroline Storey-London, Elise Bismuth, Héléna Mosbah, Héléna Mosbah, Bruno Donadille, Bruno Donadille, Sonja Janmaat, Sonja Janmaat, Bruno Fève, Bruno Fève, Isabelle Jéru, Isabelle Jéru, Isabelle Jéru, Corinne Vigouroux, Corinne Vigouroux, Corinne Vigouroux   +20 more
doaj   +1 more source

Hypertriglyceridemia in equines with refractory hyperinsulinemia treated with SGLT2 inhibitors

Open Veterinary Journal, 2023
Background: Sodium-Glucose CoTransporter-2 [SGLT2] inhibitors, the -flozin group of drugs, which block glucose reuptake in the renal proximal tubule, are being increasingly used off-label to treat horses with refractory hyperinsulinemia. After two years
Eleanor M. Kellon, Kathleen M. Gustafson
doaj   +1 more source

Pregnancy in Women With Monogenic Diabetes due to Pathogenic Variants of the Glucokinase Gene: Lessons and Challenges

Frontiers in Endocrinology, 2022
Heterozygous loss-of-function variants of the glucokinase (GCK) gene are responsible for a subtype of maturity-onset diabetes of the young (MODY). GCK-MODY is characterized by a mild hyperglycemia, mainly due to a higher blood glucose threshold for ...
José Timsit, José Timsit, José Timsit, Cécile Ciangura, Cécile Ciangura, Cécile Ciangura, Danièle Dubois-Laforgue, Danièle Dubois-Laforgue, Danièle Dubois-Laforgue, Danièle Dubois-Laforgue, Cécile Saint-Martin, Cécile Saint-Martin, Christine Bellanne-Chantelot, Christine Bellanne-Chantelot, Christine Bellanne-Chantelot   +14 more
doaj   +1 more source

Possible dysmetabolic hyperferritinemia in hyperinsulinemic horses [PDF]

Open Veterinary Journal, 2019
Background: Hyperinsulinemia associated with equine metabolic syndrome (EMS) and pituitary pars intermedia dysfunction (PPID) is a risk factor for laminitis.
Eleanor M. Kellon, Kathleen M. Gustafson
doaj   +1 more source

Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A [PDF]

, 2014
International audienceAims/Hypothesis: Reduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated fatty acids (MUFA and PUFA) not only improve ...
A El-Yassimi, A Gray, A Kowluru, A Kowluru, A Soto-Guzman, Alexander Gray, B Xue, C Schmitz-Peiffer, Christopher Lipina, CL Kien, CL Kien, CL Kien, CM Blouin, D Fedor, David Magill, DJ Powell, DJ Powell, E Hajduch, Eric Hajduch, Francesca Nardi, G Boden, H Cao, Harinder S. Hundal, J Chen, JA Chavez, JT Vilquin, Juergen Eckel, K Macrae, KD Copps, L Salvado, L Yuzefovych, LG Gillingham, M Andjelkovic, M Parillo, MM Bradford, MR Junttila, N Dimopoulos, P Seshacharyulu, PJ Eichhorn, R Cazzolli, R Hage Hassan, RA DeFronzo, Rima Hage Hassan, S Stratford, S Turban, SE Kahn, T Coll, T Galbo, T Galbo, V Janssens, XT Feng, Y Mitsumoto, Y Wu   +52 more
core   +26 more sources

New Insulins, Biosimilars, and Insulin Therapy [PDF]

Diabetes Technology & Therapeutics, 2016
Exogenous insulin has greatly changed the outlook for patients with diabetes ever since its discovery and isolation. Yet, serious complications can result as patients experience both hyperglycemic and hypoglycemic states, even when they strictly follow an insulin regimen. Several chemically or genetically modified insulins have been developed that tune
Lutz Heinemann, Thomas Danne, Jan Bolinder   +2 more
openaire   +13 more sources

Dunnigan lipodystrophy syndrome: French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins)

Orphanet Journal of Rare Diseases, 2022
Dunnigan syndrome, or Familial Partial Lipodystrophy type 2 (FPLD2; ORPHA 2348), is a rare autosomal dominant disorder due to pathogenic variants of the LMNA gene. The objective of the French National Diagnosis and Care Protocol (PNDS; Protocole National
H. Mosbah, B. Donadille, C. Vatier, S. Janmaat, M. Atlan, C. Badens, P. Barat, S. Béliard, J. Beltrand, R. Ben Yaou, E. Bismuth, F. Boccara, B. Cariou, M. Chaouat, G. Charriot, S. Christin-Maitre, M. De Kerdanet, B. Delemer, E. Disse, N. Dubois, B. Eymard, B. Fève, O. Lascols, P. Mathurin, E. Nobécourt, A. Poujol-Robert, G. Prevost, P. Richard, J. Sellam, I. Tauveron, D. Treboz, B. Vergès, V. Vermot-Desroches, K. Wahbi, I. Jéru, M. C. Vantyghem, C. Vigouroux   +36 more
doaj   +1 more source

Insulin-Like Growth Factor II (IGF-II) Is More Potent Than IGF-I in Stimulating Cortisol Secretion from Cultured Bovine Adrenocortical Cells: Interaction with the IGF-I Receptor and IGF-Binding Proteins [PDF]

, 1995
Although the stimulating effect of insulin-like growth factor I (IGF-I) on adrenal steroidogenesis has been well established, the role of IGF-II in the adult adrenal gland remains unknown.
Engelhardt, Dieter, Fottner, Christian, Simmler, Pia, Weber, Matthias M.   +3 more
core   +1 more source

Insulin begets insulin [PDF]

European Journal of Endocrinology, 1999
The pathogenesis of type 2 diabetes is characterized by insulin resistance, primarily in skeletal muscle, fat and liver, and a relative failure of the pancreatic b-cell (1, 2). Considerable controversy surrounds the issue of which of these deficiencies is the primary cause of diabetes.
openaire   +3 more sources