Results 241 to 250 of about 2,129,772 (314)

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Additive Benefits of Control-IQ+ AID to GLP-1 Receptor Agonist Use in Adults With Type 2 Diabetes. [PDF]

Diabetes Care
Graham TE, Raghinaru D, Afreen S, Ahmann A, Haidar A, Raskin P, Tsoukas MA, Lum JW, Sasson-Katchalski R, Pinsker JE, Beck RW, 2IQP Study Group* .   +11 more
europepmc   +1 more source

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

, 2010
Brian J. Smith, Kun Huang, G.K.-W. Kong, Shu Jin Chan, Satoe H. Nakagawa, John G. Menting, Shi-Quan Hu, Jonathan Whittaker, Donald F. Steiner, Panayotis G. Katsoyannis, Colin W. Ward, Michael A. Weiss, Michael C. Lawrence   +12 more
openalex   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Intrapartum Glycemic Control and Clinical Outcomes. [PDF]

Diabetes Spectr
Bitar G, Fishel Bartal M.
europepmc   +1 more source

Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity

, 2013
Harald Staiger, Anja Böhm, Mika Scheler, Lucia Berti, Jürgen Machann, Fritz Schick, Fausto Machicao, Andreas Fritsche, Norbert Stefan, Cora Weigert, Anna Krook, Hans‐Ulrich Häring, Martin Hrabě de Angelis   +12 more
openalex   +2 more sources

4D Bioprinted Self‐Folding Scaffolds Enhance Cartilage Formation in the Engineering of Trachea

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
A bilayer self‐folding scaffold, triggerable by humidity, is fabricated via 4D bioprinting for trachea engineering. An analytical model is derived to predict its radius of curvature, enabling its scalability. Cartilage progenitor cells seeded on the scaffold perceive scaffold final curvature and react to it, by enhancing the upregulation of pro ...
Irene Chiesa, Alessio Esposito, Giovanni Vozzi, Riccardo Gottardi, Carmelo De Maria   +4 more
wiley   +1 more source

A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes

, 2014
Farah Alghamdi, Merry Guo, Samar Abdulkhalek, Nicola Crawford, Schammim Ray Amith, Myron R. Szewczuk   +5 more
openalex   +1 more source

3D‐Printed Mixed Ionic‐Electronic Conductive Polymer Composites for Long‐Term Bioelectronic Sensing

Advanced Materials Technologies, EarlyView.
This study demonstrates a formulation of polymer ink for 3D‐printable, conformable ECG patches for long‐term heart monitoring. The resulting electrodes exhibit high signal fidelity and stability, rivaling metal‐based probes after extended ambient storage.
Simone Bagatella, Heejung Roh, Marco Cavallaro, Raffaella Suriano, Marinella Levi, Aristide Gumyusenge   +5 more
wiley   +1 more source

iCatCare 2025 consensus guidelines on the diagnosis and management of diabetes mellitus in cats. [PDF]

J Feline Med Surg
Taylor S, Cannon M, Church D, Fleeman L, Fracassi F, Gilor C, Mott J, Niessen S.   +7 more
europepmc   +1 more source