Results 21 to 30 of about 1,954,495 (262)
Investigations into the absorption of insulin and insulin derivatives from the small intestine of the anaesthetised rat [PDF]
, 2016 Experiments have been undertaken to determine the extent to which cholic acid conjugates of insulin were absorbed from the small intestine of anaesthetised rats by means of the bile salt transporters of the ileum.
McGinn, B.J., Morrison, J.D.
core +1 more source
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites [PDF]
, 2016 Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T ...
Acevedo-Suárez +59 more
core +2 more sources
STAR Protocols, 2023 Summary: Human subcutaneous adipocytes are an attractive therapeutic target in regulating overall physiological homeostasis. However, the differentiation of primary human adipose-derived models remains challenging.
Ajit Regmi, William Roell
doaj
The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver [PDF]
, 2019 Secreted frizzled-related protein (sFRP) 4 is an adipokine with increased expression in white adipose tissue from obese subjects with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).
Al-Hasani, Hadi +12 more
core +1 more source
Biosimilar Insulin and Insulin Antibodies [PDF]
Journal of Diabetes Science and Technology, 2013 The introduction of biosimilar insulins in regulated markets is anticipated to happen in the next few years.1,2 However, biosimilar insulins are already on the market in a number of countries with little or no guidelines for approval of biosimilars and where approval is relatively easy to obtain.
David R. Owens, Lutz Heinemann
openaire +2 more sources
Security, extensibility, and redundancy in the Metabolic Operating System [PDF]
arXiv, 2023 People living with Type 1 Diabetes (T1D) lose the ability to produce insulin naturally. To compensate, they inject synthetic insulin. One common way to inject insulin is through automated insulin delivery systems, which use sensors to monitor their metabolic state and an insulin pump device to adjust insulin to adapt.
arxiv
Comparative Analysis of Kinetic Realizations of Insulin Signaling [PDF]
arXiv, 2023 Several studies have developed dynamical models to understand the underlying mechanisms of insulin signaling, a signaling cascade that leads to the translocation of glucose, the human body's main source of energy. Fortunately, reaction network analysis allows us to extract properties of dynamical systems without depending on their model parameter ...
arxiv
Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity. [PDF]
, 2015 Insulin resistance (IR) is a metabolic disorder characterized by impaired insulin signaling and cellular glucose uptake. The current paradigm for insulin signaling centers upon the insulin receptor (InsR) and its substrate IRS1; the latter is believed to
Aznar, Nicolas +8 more
core +2 more sources
The prevalence of the metabolic syndrome in Portugal: the PORMETS study
BMC Public Health, 2017 Background The PORMETS study was designed to estimate the prevalence of metabolic syndrome and its determinants in the overall and administrative regions of the Portuguese mainland.
Luís Raposo +3 more
doaj +1 more source