Insulin Resistance and its Relevance with Age, Sex, Season and Obesity in Darehshori Horse Breed [PDF]
Iranian Journal of Veterinary Medicine, 2019 BACKGROUND: Equine metabolic syndrome is an endocrinopathy that affects different breeds of horses and ponies. This metabolic disorder is a multifactorial syndrome and it is primarily linked to obesity, dyslipidemia and insulin resistance.
Ali Sadeghpour +4 more
doaj +1 more source
Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity. [PDF]
, 2015 Insulin resistance (IR) is a metabolic disorder characterized by impaired insulin signaling and cellular glucose uptake. The current paradigm for insulin signaling centers upon the insulin receptor (InsR) and its substrate IRS1; the latter is believed to
Aznar, Nicolas +8 more
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Clinical and Translational Medicine, 2021 Among the prognostic and predictive biomarkers of breast cancer (BC), the role of estrogen receptor (ER)α wild‐type has been acknowledged, although the action of certain ERα splice variants has not been elucidated.
Francesca Cirillo +13 more
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Changes in insulin sensitivity over time and associated factors in HIV-infected adolescents [PDF]
, 2018 OBJECTIVE: To compare prevalence of insulin resistance between perinatally HIV-infected (PHIV+) and perinatally HIV-exposed, but uninfected adolescents (PHEU), determine incidence of and contributory factors to new and resolved cases of insulin ...
Dimeglio, Linda A. +13 more
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Insulin resistance and type 2 diabetes in children [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2020 Type 2 diabetes (T2D) is an emerging health risk in obese children and adolescents. Both environmental (lack of physical activity, excess nutritional intake, sedentary lifestyle) and genetic factors contribute to this global epidemic.
Valeria Castorani +4 more
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Serum IgG2 levels are specifically associated with whole-body insulin-mediated glucose disposal in non-diabetic offspring of type 2 diabetic individuals. a cross-sectional study [PDF]
, 2018 .Preclinical studies suggested that IgG2c isotype may specifically impair skeletal muscle insulin sensitivity in mice. In this study we investigated the association between serum levels of the four IgG subclasses and insulin sensitivity in non-diabetic
Andreozzi, F +11 more
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Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. [PDF]
, 2017 Disruption of hepatocyte growth hormone (GH) signaling through disruption of Jak2 (JAK2L) leads to fatty liver. Previously, we demonstrated that development of fatty liver depends on adipocyte GH signaling.
Camporez, João Paulo G +10 more
core +1 more source
Improvement in Glycemic and Lipid Profiles in Type 2 Diabetics with a 90-Day Ketogenic Diet
Journal of Diabetes Research, 2019 Because low-carbohydrate diets are effective strategies to improve insulin resistance, the hallmark of type 2 diabetes, the purpose of reporting these clinical cases was to reveal the meaningful changes observed in 90 days of low-carbohydrate (LC ...
Chase M. Walton +4 more
doaj +1 more source
Systematic Survey of the Role of IGF in the Link Between Diabetes and Cancer [PDF]
, 2018 Epidemiological studies have proposed a link between type II diabetes and cancer via the IGF/insulin signaling pathway, which includes insulin-like peptides (IGF1, IGF2, and insulin), insulin receptors (IR-A, IR-B, IGF1R, and hybrids), and insulin ...
Devanathan, Nirupama +1 more
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Orphanet Journal of Rare DiseasesBackground Rare syndromes of lipodystrophy and insulin-resistance display heterogeneous clinical expressions. Their early recognition, diagnosis and management are required to avoid long-term complications.
Bruno Donadille +10 more
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