Results 41 to 50 of about 2,674,610 (386)

European lipodystrophy registry: background and structure

Orphanet Journal of Rare Diseases, 2020
Background Lipodystrophy syndromes comprise a group of extremely rare and heterogeneous diseases characterized by a selective loss of adipose tissue in the absence of nutritional deprivation or catabolic state. Because of the rarity of each lipodystrophy
Julia von Schnurbein, Claire Adams, Baris Akinci, Giovanni Ceccarini, Maria Rosaria D’Apice, Alessandra Gambineri, Raoul C. M. Hennekam, Isabelle Jeru, Giovanna Lattanzi, Konstanze Miehle, Gabriele Nagel, Giuseppe Novelli, Ferruccio Santini, Ermelinda Santos Silva, David B. Savage, Paolo Sbraccia, Jannik Schaaf, Ekaterina Sorkina, George Tanteles, Marie-Christine Vantyghem, Camille Vatier, Corinne Vigouroux, Elena Vorona, David Araújo-Vilar, Martin Wabitsch   +24 more
doaj   +1 more source

Effect of knocking down the insulin receptor on mouse rod responses. [PDF]

, 2015
Previous experiments have shown that the insulin receptor (IR) is expressed in mammalian rods and contributes to the protection of photoreceptors during bright-light exposure.
Fain, Gordon L, Rajala, Ammaji, Rajala, Raju VS, Woodruff, Michael L   +3 more
core   +3 more sources

Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A [PDF]

, 2014
International audienceAims/Hypothesis: Reduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated fatty acids (MUFA and PUFA) not only improve ...
A El-Yassimi, A Gray, A Kowluru, A Kowluru, A Soto-Guzman, Alexander Gray, B Xue, C Schmitz-Peiffer, Christopher Lipina, CL Kien, CL Kien, CL Kien, CM Blouin, D Fedor, David Magill, DJ Powell, DJ Powell, E Hajduch, Eric Hajduch, Francesca Nardi, G Boden, H Cao, Harinder S. Hundal, J Chen, JA Chavez, JT Vilquin, Juergen Eckel, K Macrae, KD Copps, L Salvado, L Yuzefovych, LG Gillingham, M Andjelkovic, M Parillo, MM Bradford, MR Junttila, N Dimopoulos, P Seshacharyulu, PJ Eichhorn, R Cazzolli, R Hage Hassan, RA DeFronzo, Rima Hage Hassan, S Stratford, S Turban, SE Kahn, T Coll, T Galbo, T Galbo, V Janssens, XT Feng, Y Mitsumoto, Y Wu   +52 more
core   +7 more sources

Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. [PDF]

, 2015
Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes. The endo/lysosomal trafficking system may coordinate insulin action and nutrient homeostasis by endocytosis of IR and ...
Burnol, Anne-Françoise, Guan, Kun-Liang, Montagnac, Guillaume, Morzyglod, Lucille, Nemazanyy, Ivan, Panasyuk, Ganna, Pende, Mario, Russell, Ryan C   +7 more
core   +1 more source

Association between insulin resistance and the development of cardiovascular disease

Cardiovascular Diabetology, 2018
For many years, cardiovascular disease (CVD) has been the leading cause of death around the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid profiles and insulin resistance.
V. Ormazábal, Soumyalekshmi Nair, Omar Elfeky, C. Aguayo, C. Salomon, F. Zúñiga   +5 more
semanticscholar   +1 more source

Angiotensin(1–7) activates MAS-1 and upregulates CFTR to promote insulin secretion in pancreatic β-cells: the association with type 2 diabetes

Endocrine Connections, 2022
Objective: The beneficial effect of angiotensin(1–7) (Ang(1–7)), via the ac tivation of its receptor, MAS-1, has been noted in diabetes treatment; however, how Ang(1–7) or MAS-1 affects insulin secretion remains elusive and whether the endoge nous level ...
Xue-Lian Zhang, Xinyi Zhao, Yong Wu, Wen-qing Huang, Jun-jiang Chen, Peijie Hu, Wei Liu, Yi-Wen Chen, Jin Hao, Rong-Rong Xie, Hsiao Chang Chan, Ye Chun Ruan, Hui Chen, Jinghui Guo   +13 more
doaj   +1 more source

Improvement in Glycemic and Lipid Profiles in Type 2 Diabetics with a 90-Day Ketogenic Diet

Journal of Diabetes Research, 2019
Because low-carbohydrate diets are effective strategies to improve insulin resistance, the hallmark of type 2 diabetes, the purpose of reporting these clinical cases was to reveal the meaningful changes observed in 90 days of low-carbohydrate (LC ...
Chase M. Walton, Katelyn Perry, Richard H. Hart, Steven L. Berry, Benjamin T. Bikman   +4 more
doaj   +1 more source

Urocortin 2 Gene Transfer Improves Glycemic Control and Reduces Retinopathy and Mortality in Murine Insulin Deficiency. [PDF]

, 2020
Type 1 diabetes affects 20 million patients worldwide. Insulin is the primary and commonly the sole therapy for type 1 diabetes. However, only a minority of patients attain the targeted glucose control and reduced adverse events.
Bhargava, Raag, Gao, Mei Hua, Giamouridis, Dimosthenis, Guo, Tracy, Hammond, H Kirk, Huu, Viet Anh Nguyen, Kim, Young Chul, Lai, N Chin, Lantier, Louise, Skowronska-Krawczyk, Dorota, Xia, Bing   +10 more
core  

Circulating free fatty acids, insulin, and glucose during chemical stimulation of hypothalamus in rats [PDF]

, 1984
The aim of this study was to investigate plasma free fatty acids (FFA), insulin, and blood glucose during chemical stimulation of the lateral and ventromedial hypothalamic areas (LHA and VMH) in rats.
Damsma, G.,, Gugten, J. van der,, Luiten, P.G.M.,, Steffens, A.B.,   +3 more
core   +1 more source

Diagnostic and referral pathways in patients with rare lipodystrophy and insulin-resistance syndromes: key milestones assessed from a national reference center

Orphanet Journal of Rare Diseases
Background Rare syndromes of lipodystrophy and insulin-resistance display heterogeneous clinical expressions. Their early recognition, diagnosis and management are required to avoid long-term complications.
Bruno Donadille, Sonja Janmaat, Héléna Mosbah, Inès Belalem, Sophie Lamothe, Mariana Nedelcu, Anne-Sophie Jannot, Sophie Christin-Maitre, Bruno Fève, Camille Vatier, Corinne Vigouroux   +10 more
doaj   +1 more source