Results 211 to 220 of about 269,490 (301)

Hepatoma‐Derived Growth Factor Coordinates STAT3 Pathway and Exosome‐Mediated Intrahepatic Crosstalk to Control Hepatic Steatosis and MASLD

Advanced Science, EarlyView.
Hepatic HDGF as a key mediator in coordinating hepatic steatosis and intrahepatic crosstalk in MASLD. Activation of HDGF facilitates its interaction with both STAT3 and S6K1, driving the S6K1‐dependent STAT3 phosphorylation and subsequently enhancing hepatic lipogenesis.
Jian Wen, Dong Ding, Zengpeng Zheng, Xufeng Chen, Wenjing Li, Jiaxin Shen, Zhiwei Huang, Peng Tan, Junjie Bai, Xia Fang, Baofang Xing, Puyuan Hu, Linghao Xu, Haokai Yu, Yixi Wang, Zongzhe Jiang, Yang Long, Tiejun Zhou, Mingxin Ye, Yu Jiang, Aoyuan Cui, Hong Li, Qiurong Ding, Yong Xu, Yu Li, Weitong Su, Feng Shen, Chenlin Gao, Wenguang Fu   +28 more
wiley   +1 more source

Severe autoimmunity after checkpoint inhibitor therapy in a patient with autoimmune polyglandular syndrome type 1. [PDF]

JCEM Case Rep
Lim A, Peluso EM, Downs IA, Horwich BH, Velez-Velez MA, Lechner MG.   +5 more
europepmc   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

Insulin Receptor-Related Receptor Activation by Artificial Double-ER Mutations in the Transmembrane Domain. [PDF]

Int J Mol Sci
Serova OV, Gavrilenkova AA, Kuznetsov AS, Goryashchenko AS, Agisheva AR, Bershatsky YV, Lushpa VA, Zangieva OT, Karbyshev MS, Gerasimov AS, Okhrimenko IS, Efremov RG, Deyev IE, Bocharov EV.   +13 more
europepmc   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Delayed Hypersensitivity Reaction to Insulin: A Case Report. [PDF]

Cureus
Aharmim M, Lakhal M, Reguig N, El Bourkadi JE.   +3 more
europepmc   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Insulin enables acquisition of the IL7R⁺ memory phenotype in PD1⁺ T cells in RA tissues. [PDF]

Cell Death Dis
Chandrasekaran V, Erlandsson MC, Svensson D, Malmhäll-Bah E, Silfverswärd ST, Pullerits R, Katona G, Bokarewa MI.   +7 more
europepmc   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Extracellular 70 kDa heat shock protein in blood plasma binds insulin and modulates glycaemic control in vivo. [PDF]

Cell Stress Chaperones
Ludwig MS, Heck TG, Minguetti-Câmara VC, Schroeder HT, de Lemos Muller CH, Bittencourt A, Scomazzon SP, Bruxel MA, Porto RR, Bandeira BB, Souza Borges V, Goettems-Fiorin PB, Baldissera FG, Schöler CM, Bock PM, Rodrigues MIL, Nunes PR, Hoefel AL, Miragem AA, Krause M, Grunwald MS, Pedebos C, Ligabue-Braun R, Moreira JCF, Curi R, Bazotte RB, Homem de Bittencourt PI.   +26 more
europepmc   +1 more source