Results 231 to 240 of about 269,490 (301)

Type B Insulin Resistance: A Case Report of a Rare Complication of Systemic Lupus Erythematosus. [PDF]

J Rheumatol
Ogbonnaya SA, Williams S, Lightbourne M, Brown RJ.   +3 more
europepmc   +1 more source

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, EarlyView.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Thyroid autoimmunity in relation to islet autoantibodies in newly diagnosed type 1 diabetes mellitus in children and adolescents. [PDF]

Front Endocrinol (Lausanne)
Zhu Y, Yang H, Hu C, Qiao L, Li C, Hu S.
europepmc   +1 more source

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, EarlyView.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source

A Case Report: Treatment, follow-up, and literature review of type A insulin resistance syndrome caused by a <i>De Novo</i> INSR c.3328G>C mutation. [PDF]

Front Endocrinol (Lausanne)
Ji C, Zheng X, Wang Q, Chen Z.
europepmc   +1 more source

WFS1-related isolated diabetes induced by a WFS1 missense mutation: focus on the isolated diabetes phenotype. [PDF]

Orphanet J Rare Dis
Huang M, Wei Q, Qin Y, Qin L, Shao Y, Wang S, Qu X, Yang T, Zhang M.   +8 more
europepmc   +1 more source

Combined immune checkpoint inhibitor-induced type 1 diabetes: a rare but serious endocrinopathy. [PDF]

JCEM Case Rep
Emami K, Goyal S, Akula V, Amoakohene P.
europepmc   +1 more source