Effects of insulin detemir and NPH insulin on body weight and appetite-regulating brain regions in human type 1 diabetes: a randomized controlled trial. [PDF]
PLoS ONE, 2014 Studies in rodents have demonstrated that insulin in the central nervous system induces satiety. In humans, these effects are less well established.
Larissa W van Golen +7 more
doaj +17 more sources
Insulin analogues dosing and costs - comparing real-life daily doses of insulin detemir and insulin glargine in type 2 diabetes patients [PDF]
BMC Endocrine Disorders, 2012 Background The uncertainties regarding dose similarities between basal long-acting insulin analogues remain. Recent real-world studies indicate dose similarities between insulin detemir and insulin glargine, but further studies are still warranted.
Jakobsen Marie +3 more
doaj +2 more sources
Sustained Treatment with Insulin Detemir in Mice Alters Brain Activity and Locomotion. [PDF]
PLoS ONE, 2016 AIMS:Recent studies have identified unique brain effects of insulin detemir (Levemir®). Due to its pharmacologic properties, insulin detemir may reach higher concentrations in the brain than regular insulin.
Tina Sartorius +3 more
doaj +2 more sources
Risk of Major Congenital Malformations or Perinatal or Neonatal Death With Insulin Detemir Versus Other Basal Insulins in Pregnant Women With Preexisting Diabetes: The Real-World EVOLVE Study. [PDF]
Diabetes Care, 2021 Mathiesen ER +15 more
europepmc +5 more sources
Comparative study of the usefulness of a novel insulin therapy in Japanese patients with Type 2 diabetes for concomitant use of an oral antidiabetic agent with twice-daily dosing either of insulin aspart, biphasic insulin aspart-30, or insulin detemir: Two times Insulin injection Combined with oral therapy Efficacy Study (TWICE study) [PDF]
Fujita Medical Journal, 2021 Objectives: It is common to treat type 2 diabetes by regular injections of insulin. We compared the efficacy and safety of twice-daily administration of short-acting, premixed, and long-acting insulins.
Mitsuyasu Itoh +9 more
doaj +2 more sources
Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2008 Aim: Since there is limited number of studies in medical literature regarding the efficiency of in-sulin detemir, decrease in number of night hypoglycemia, weight changes and the improvement the lipid profile in pediatric and adolescent age group, we ...
Tolga Ünüvar +4 more
doaj +3 more sources
Journal of the ASEAN Federation of Endocrine Societies, 2011 Objective. To evaluate the safety and efficacy of insulin detemir in patients with diabetes mellitus in Indonesia. Methods. This was a multi-centre, prospective, 12-week observational study in patients with diabetes mellitus conducted in Indonesia.
Pradana Soewondo, Anand Jain
doaj +2 more sources
Cost-Effectiveness Analysis of Insulin Detemir Compared to Neutral Protamine Hagedorn (NPH) in Patients with Type 1 and Type 2 Diabetes Mellitus in Spain [PDF]
, 2015 Introduction: An Excel® (Microsoft Corporation) model was adapted to estimate the short-term (1-year) cost effectiveness of insulin detemir (IDet) versus neutral protamine Hagedorn (NPH) insulin in patients initiating insulin treatment with type 1 ...
Cristóbal Morales +4 more
openalex +5 more sources
The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus [PDF]
Diabetology & Metabolic Syndrome, 2017 Background Type II diabetes is an important health problem with a complex connection to obesity, leading to a broad range of cardiovascular complications.
Tomislav Bozek +8 more
doaj +2 more sources
Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir [PDF]
Molecules, 2017 The aim of the present study is to quantitatively assess the expression of selected regulatory molecules, such as leptin, leptin receptor, and adiponectin in the blood of obese patients with type 2 diabetes both before treatment and after six months of ...
Paweł Olczyk +9 more
doaj +2 more sources