Results 71 to 80 of about 1,795,545 (198)

Insulin-loaded alginic acid nanoparticles for sublingual delivery

Drug Delivery, 2014
Alginic acid nanoparticles (NPs) containing insulin, with nicotinamide as permeation enhancer were developed for sublingual delivery. The lower concentration of proteolytic enzymes, lower thickness and enhanced retention due to bioadhesive property, were relied on for enhanced insulin absorption.
Nilam H, Patil, Padma V, Devarajan
openaire   +2 more sources

Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]

, 2009
Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Boyd, Alasdair R., Stuart A. Ritchie, Ian P. Salt, Salt, Ian P., Kohlhaas, Christine F, Yalla, Krishna C, Kohlhaas, Christine F., Boyd, Alasdair R, Krishna C. Yalla, Walsh, Kenneth, Ritchie, Stuart A, John M. C. Connell, Christine F. Kohlhaas, Kenneth Walsh, Ritchie, Stuart A., Connell, John M.C., Connell, John Mc, Salt, Ian P, Alasdair R. Boyd, Yalla, Krishna C.   +19 more
core   +1 more source

The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load.

PLoS ONE, 2009
BackgroundPolymorphisms in the potassium channel, voltage-gated, KQT-like subfamily, member 1 (KCNQ1) have recently been reported to associate with type 2 diabetes.
Johan Holmkvist, Karina Banasik, Gitte Andersen, Hiroyuki Unoki, Thomas Skot Jensen, Charlotta Pisinger, Knut Borch-Johnsen, Annelli Sandbaek, Torsten Lauritzen, Sören Brunak, Shiro Maeda, Torben Hansen, Oluf Pedersen   +12 more
doaj   +1 more source

Inhaled Insulin: Intrapulmonary or Intranasal? [PDF]

, 2012
Initial attempts delivered the insulin hormone intramuscularly, intravenously, and eventually subcutaneously. Other routes of administration of the drug were explored.
Shivangi Jaiswal, Danish Ahmed, Shruti Mishra, Sweta Kumari   +3 more
core   +1 more source

Post–Glucose Load Measures of Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundInsulin resistance is associated with an increased risk of cardiovascular events in the general population. This study aimed to estimate the association between post–glucose load measures of insulin resistance and prognosis of nondiabetic ...
Yuesong Pan, Jing Jing, Weiqi Chen, Huaguang Zheng, Qian Jia, Donghua Mi, Hao Li, Xingquan Zhao, Liping Liu, Chunxue Wang, Herbert Y. Gaisano, Yan He, Yilong Wang, Yongjun Wang   +13 more
doaj   +1 more source

Insulin action in skeletal muscle from patients with NIDDM

, 1998
Insulin resistance in peripheral tissues is a common feature of non insulin-dependent diabetes mellitus (NIDDM). The decrease in insulin-mediated peripheral glucose uptake in NIDDM patients can be localized to defects in insulin action on glucose ...
Wallberg-Henriksson, H, Juleen R. Zierath, Harriet Wallberg-Henriksson, Anna Krook, Krook, A, Zierath, JR   +5 more
core   +1 more source

Recombinant human preproinsulin expression, purification and reaction with insulin autoantibodies in sera from patients with insulin-dependent diabetes mellitus [PDF]

, 1993
A novel prokaryotic expression vector pGEX-6T was designed for high-level expression of recombinant fusion protein with a histidine-hexapeptide and glutathione-S-transferase at its N-terminus and the recombinant human preproinsulin at its C-terminus ...
Seißler, Jochen, Mauch, Ludwig, Walter, Michael, Northemann, Wolfgang, Berg, Heike   +4 more
core   +1 more source

Similar Blood Glucose Pattern with Highest Peak at Minute 45 on Oral Glucose Tolerance Test Despite Higher Fasting Insulin and Insulin Resistance in Healthy Obese than Non-Obese Subject

Acta Medica Indonesiana, 2022
Background: Obesity increase the risk for type 2 diabetes through induction of insulin resistance. Diagnosis of diabetes were based on blood glucose level. However, insulin resistance may had happened far before diagnosis itself.
Made Ratna Saraswati, Ida Bagus Aditya Nugraha, Ketut Suastika   +2 more
doaj   +2 more sources

Mechanisms linking glucotoxicity to the development of insulin resistance: a role for the endoplasmic reticulum stress [PDF]

, 2010
Aims/hypothesis: Glucosamine, generated during hyperglycaemia, causes insulin resistance in different cells. Here we sought to evaluate the possible role of ER stress in the induction of insulin-resistance by glucosamine in skeletal muscle cells. Methods:
Iadicicco, Claudia
core   +1 more source

Acute hormonal response to glucose, lipids and arginine infusion in overweight cats

Journal of Nutritional Science, 2014
In cats, the incidence of obesity and diabetes is increasing, and little is known about specific aspects of the endocrine control of food intake in this species.
Lucile J. M. Martin, Thomas A. Lutz, Caroline Daumas, Philippe Bleis, Patrick Nguyen, Vincent Biourge, Henri J. W. Dumon   +6 more
doaj   +1 more source