Results 101 to 110 of about 222,467 (377)

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Sustained impact of real-time continuous glucose monitoring in adults with type 1 diabetes on insulin pump therapy: Results after 24 months RESCUE study [PDF]

, 2020
Sara Charleer, Christophe De Block, Frank Nobels, Régis Radermecker, Ine Lowyck, Annelies Mullens, Denis Scarnière, Katrien Spincemaille, Marie Strivay, E. Weber, Youri Taes, Chris Vercammen, Bart Keymeulen, Chantal Mathieu, Pieter Gillard, the RESCUE trial investigators   +15 more
openalex   +1 more source

The Relative Effectiveness of Pumps Over MDI and Structured Education (REPOSE): study protocol for a cluster randomised controlled trial [PDF]

, 2014
Introduction People with type 1 diabetes (T1DM) require insulin therapy to sustain life, and need optimal glycaemic control to prevent diabetic ketoacidosis and serious long-term complications.
American Diabetes Association Consensus Panel, Bott, Colquitt, Cox, Cummins, DAFNE Study Group, Elliott, EuroQol, Heller, Hopkins, Leotta, Lepore, Lewis, Muhlhauser, Muhlhauser, Nixon, Pedersen-Bjergaard, Pickup, Pickup, Pickup, Ramsey, Rubin, Samann, Seaquist, Secnik Boye, Siebenhofer, Tamborlane, The Diabetes Control and Complications Trial Research Group, The WHOQOL Group, Thokala, UK Hypoglycaemia Study Group, Ware, Zigmond   +32 more
core   +4 more sources

Oxygen Supply of Islets of Langerhans by Photosynthetically Active Microalgae in Bioprinted Co‐Cultures Maintains Their Function in a Hypoxic Environment

Advanced Healthcare Materials, EarlyView.
This study developed a bioprinted co‐culture system embedding rat pancreatic islets and Scenedesmus sp. microalgae spatially defined in close vicinity. Red light was found optimal to ensure microalgal photosynthesis while maintaining islet viability and functionality. A tailored co‐culture medium supported both cell types.
Finn Dani, Sarah Duin, Ashwini Rahul Akkineni, Susann Lehmann, Barbara Ludwig, Michael Kühl, Michael Gelinsky, Anja Lode   +7 more
wiley   +1 more source

Attitudes and habits of patients with type 1 diabetes during fasting Ramadan

Journal of Clinical & Translational Endocrinology, 2018
Objective: Fasting Ramadan is associated with changes in lifestyle patterns of patients with diabetes who choose to perform fasting. We aimed to determine the attitude and habits of patients with type 1 diabetes during fasting Ramadan. Methods: The study
Reem Alamoudi, Maram Alsubaiee, Ali Alqarni, Saleh Aljaser, Yousef Saleh, Abdul salam, Mohsen Eledrisi   +6 more
doaj   +1 more source

Emerging technologies for the management of Type 1 diabetes in pregnancy [PDF]

, 2018
Purpose of Review: The purpose of the study is to discuss emerging technologies available in the management of type 1 diabetes in pregnancy. Recent Findings: The latest evidence suggests that continuous glucose monitoring (CGM) should be offered to all ...
A Garcia-Patterson, A Weisman, AL Secher, AL Secher, C Farrington, D Bruttomesso, DN Voormolen, DS Feig, DS Feig, E Drever, E Wender-Ozegowska, EA Ryan, FM Moy, GR Law, GR Law, Helen R. Murphy, HR Murphy, HR Murphy, HR Murphy, HR Murphy, HR Murphy, HR Murphy, IM Evers, JC Pickup, Jennifer M. Yamamoto, JK Radder, K Cypryk, KJ Neff, M Berg, MJ Maresh, MM Kallas-Koeman, PD Ranasinghe, R Chen, R Fresa, R Worth, RJ Goudie, RM Bergenstal, RW Beck, SK Abell, TS Bailey, WV Tamborlane, ZA Stewart   +41 more
core   +2 more sources

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Genomic landscapes and clonality of de novo AML [PDF]

, 2013
No abstract ...
Brewin, John, Chevassut, Timothy, Horne, Gillian   +2 more
core   +1 more source

Surface‐Capped Protein Nanoparticles for Nonviral Gene Delivery

Advanced Materials, EarlyView.
ABSTRACT Developing simple, safe, and efficient nonviral delivery systems remains a significant challenge in bioengineering. Nanoparticles offer promising gene delivery capabilities with reduced toxicity; however, long‐standing challenges related to effective plasmid encapsulation and delivery exist.
Fjorela Xhyliu, Yao Yao, Yeongun Ko, Grant Grasman, Jeffery E. Raymond, Albert Chang, Yuxuan Deng, Grant Dominic, Michael Triebwasser, Joerg Lahann   +9 more
wiley   +1 more source

Practical Strategies for Pharmacist Integration with Primary Care: A Workbook. [PDF]

, 2014
This workbook is a practical set of tips and resources to assist pharmacists in providing clinical pharmacy services to primary care providers and their patients.
Biddle, Michael A, Kennedy, Amanda G
core   +1 more source