Results 121 to 130 of about 703,862 (378)

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Reinforcement Learning-Based Adaptive Insulin Advisor for Individuals with Type 1 Diabetes Patients under Multiple Daily Injections Therapy [PDF]

arXiv, 2019
The existing adaptive basal-bolus advisor (ABBA) was further developed to benefit patients under insulin therapy with multiple daily injections (MDI). Three different in silico experiments were conducted with the DMMS.R simulator to validate the approach of combined use of self-monitoring of blood glucose (SMBG) and insulin injection devices, e.g ...
arxiv  

A high-fructose diet induces changes in pp185 phosphorylation in muscle and liver of rats

Brazilian Journal of Medical and Biological Research, 2000
Insulin stimulates the tyrosine kinase activity of its receptor resulting in the tyrosine phosphorylation of pp185, which contains insulin receptor substrates IRS-1 and IRS-2. These early steps in insulin action are essential for the metabolic effects of
M. Ueno, R.M.N. Bezerra, M.S. Silva, D.Q. Tavares, C.R. Carvalho, M.J.A. Saad   +5 more
doaj   +1 more source

Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. [PDF]

, 2001
Recent studies indicate that insulin stimulation of glucose transporter (GLUT)4 translocation requires at least two distinct insulin receptor-mediated signals: one leading to the activation of phosphatidylinositol 3 (PI-3) kinase and the other to the ...
Chiang, SH, Kanzaki, M, Macara, IG, Mora, S, Pessin, JE, Saltiel, AR, Shigematsu, S, Watson, RT   +7 more
core   +3 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Agonism and Antagonism at the Insulin Receptor

PLoS ONE, 2012
Insulin can trigger metabolic as well as mitogenic effects, the latter being pharmaceutically undesirable. An understanding of the structure/function relationships between insulin receptor (IR) binding and mitogenic/metabolic signalling would greatly facilitate the preclinical development of new insulin analogues.
Knudsen, Louise, Hansen, Bo Falck, Jensen, Pia, Pedersen, Thomas Åskov, Vestergaard, Kirsten, Schäffer, Lauge, Blagoev, Blagoy, Oleksiewicz, Martin B, Kiselyov, Vladislav V, De Meyts, Pierre Marcel Joseph   +9 more
openaire   +6 more sources

Inhibition of central insulin-receptor signaling by S961 causes hyperglycemia and glucose intolerance in rats [PDF]

, 2011
Genetic ablation studies confirmed the role of central insulin-receptor signaling (CIRS) in fuel metabolism. However, the need to examine the role of CIRS in glucose homeostasis under normal physiological condition is indispensable, as insulin affects ...
Ajit Vikram, Gopabandhu Jena
core   +1 more source

Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain [PDF]

, 2019
Glucose homeostasis and growth essentially depend on the hormone insulin engaging its receptor. Despite biochemical and structural advances, a fundamental contradiction has persisted in the current understanding of insulin ligand-receptor interactions ...
Adams, Afonine, Alvarado, Baker, Bartoschik, Bass, Beate Brankatschk, Belfiore, Bussi, Chetan Poojari, Chiacchia, Christiansen, Conway, Coskun, Croll, Danne, Darden, De Meyts, De Meyts, De Meyts, De Meyts, de Meyts, De Meyts, Delle Bovi, DeMeyts, Durocher, Emsley, Endres, Essmann, Eswar, Ferguson, Fernandes de Abreu, Fleishman, Freed, Garofalo, Gasteiger, Goddard, Gutmann, Gutmann, Hess, Hess, Horwitz, Hoyne, Hua, Humphrey, Ilpo Vattulainen, Ingmar B. Schäfer, Jiráček, Jorgensen, Kaminski, Kasuga, Kaszuba, Kavran, Kimanius, Kiselyov, Kleinridders, Lata, Lax, Leray, Longo, Luo, Mastronarde, McGreevy, McKern, Menting, Menting, Mike Strauss, Muggeo, Parrinello, Parrinello, Parrinello, Pettersen, Rentería, Rigaut, Rosenthal, Saltiel, Scapin, Schäffer, Seidel, Sparrow, Sparrow, Sparrow, Subramanian, Tatulian, Theresia Gutmann, Trabuco, Tranum-Jensen, Uchikawa, Wang, Weis, Weiss, Whittaker, Whittaker, Woldin, Xu, Xu, Ye, Zhang, Zheng, Zivanov, Ünal Coskun   +100 more
core   +2 more sources

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao, Katherine R Schon, Jana Vandrovcova, Özlem Yayıcı Köken, Sharika Raga, Kireshnee Naidu, Maryke Schoonen, Nimita Rani, Pedro Tomaselli, Dipti Baskar, Musambo Kapapa, Ipek Polat, Lindsay A Wilson, Kumarasamy Thangaraj, Uluç Yiş, Bevinahalli N Nandeesh, David Bearden, Michelle Kvalsund, Franclo Henning, Seena Vengalil, Atchayaram Nalini, Claudia F. R. Sobreira, Wilson Marques, Haluk Topoloğlu, Michael G Hanna, Sireesha Yareeda, Venugopalan Y Vishnu, Francois H van der Westhuizen, Izelle Smuts, Surita Meldau, Jo Wilmshurst, Büşranur Çavdarlı, Jeannine Heckmann, Patrick F Chinnery, Rita Horvath   +34 more
wiley   +1 more source

MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels

Nature Communications, 2016
Insulin receptor levels at the cell surface are reduced in insulin resistance, for reasons that are not fully understood. Here, the authors identify the E3 ubiquitin ligase MARCH1 as a direct regulator of basal insulin receptor surface levels and ...
Arvindhan Nagarajan, Max C. Petersen, Ali R. Nasiri, Gina Butrico, Annie Fung, Hai-Bin Ruan, Romy Kursawe, Sonia Caprio, Jacques Thibodeau, Marie-Claude Bourgeois-Daigneault, Lisha Sun, Guangping Gao, Sanjay Bhanot, Michael J. Jurczak, Michael R. Green, Gerald I. Shulman, Narendra Wajapeyee   +16 more
doaj   +1 more source