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Mutations in the insulin receptor gene
Endocrine Reviews, 1992I. Introduction THE insulin receptor is a cell surface glycoprotein that mediates the action of insulin upon target cells. The receptor was originally identified by its ability to bind the hormone (1–3). Over the past two decades, considerable progress has been made in defining the structure of the receptor molecule (4–7) as well as the biochemical ...
TAYLOR, SI +12 more
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The Insulin Receptor of the Turkey Erythrocyte: Similarity to Mammalian Insulin Receptors
Endocrinology, 1977Avian erythrocytes possess insulin receptors which have binding properties that are virtually identical to those of the well studied mammalian insulin receptors. The affinity for porcine insulin was identical for the turkey and mammalian receptors over the entire range of insulin concentrations, as was the affinity of each of four insulin analogues ...
Barry H. Ginsberg +2 more
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Insulin receptors and the site of action of insulin
Life Sciences, 1978Abstract There is considerable evidence that insulin receptors located on the plasma membrane of target cells directly mediate the short- term effects of insulin on plasma membrane functions such as glucose transport. These receptors are composed of four subunits, contain two or more binding sites, and show features of negative cooperativity. Insulin
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1989
Many hormones and other extracellular stimuli exert their effects by binding to specific receptors on the plasma membrane of cells. The receptors recognize and bind the agonists with high affinity, and are therefore responsible for initiating the cascade of reactions leading to intracellular events. The hormone-receptor complex transmits this signal in
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Many hormones and other extracellular stimuli exert their effects by binding to specific receptors on the plasma membrane of cells. The receptors recognize and bind the agonists with high affinity, and are therefore responsible for initiating the cascade of reactions leading to intracellular events. The hormone-receptor complex transmits this signal in
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Evolution of Insulin and Insulin Receptors
1987Insulin traditionally has been considered to be a unique product of the vertebrate pancreas. More recent studies, however, have suggested that there may be extrapancreatic sources of insulin and that insulin may act on tissues other than its classic target tissues.
William L. Lowe +2 more
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Annual Review of Pharmacology and Toxicology, 1983
S, Jacobs, P, Cuatrecasas
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S, Jacobs, P, Cuatrecasas
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-vornhagen +2 more
exaly