Results 221 to 230 of about 3,199,300 (285)
Some of the next articles are maybe not open access.
The insulin receptor and the kidney
Current Opinion in Nephrology and Hypertension, 2013In recent years, it has become clear that the insulin receptor is important in a variety of renal cell types. It is through this transmembrane receptor that insulin, and to a lesser extent insulin-like growth factor, hormones bind and can control important cellular functions.
Hale, Lorna J, Coward, Richard J M
openaire +4 more sources
Pathologie Biologie, 2003
The number of elderly people is increasing worldwide as well as the age-associated diseases, such as the type 2 diabetes. The consequences are disastrous for elderly patients as well as for healthy ageing. It has been clinically demonstrated that with physiological ageing it exists already a resistance to the action of insulin leading to slightly ...
Anis Larbi, Tamas Fulop, Nadine Douziech
openaire +3 more sources
The number of elderly people is increasing worldwide as well as the age-associated diseases, such as the type 2 diabetes. The consequences are disastrous for elderly patients as well as for healthy ageing. It has been clinically demonstrated that with physiological ageing it exists already a resistance to the action of insulin leading to slightly ...
Anis Larbi, Tamas Fulop, Nadine Douziech
openaire +3 more sources
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Science, 2004Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, we show that obesity causes endoplasmic reticulum (ER) stress.
Umut Özcan +9 more
semanticscholar +1 more source
Insulin Receptors and Insulin Resistance
Annual Review of Medicine, 1983Resistance to the action of insulin plays a central role in many important disease states, including diabetes and obesity. Many insights into the mechanism and significance of insulin resistance in these and other disorders have followed upon our expanding knowledge regarding insulin receptors.
openaire +2 more sources
Insulin Receptors, Receptor Antibodies, and the Mechanism of Insulin Action
1981Publisher Summary Insulin exerts a wide spectrum of effects at the cellular level. These include effects at the membrane level, for example, the stimulation of glucose and amino acid uptake; effects on both membrane and cytoplasmic enzymes; and effects on protein synthesis, DNA synthesis, cell growth, and differentiation.
Len C. Harrison +11 more
openaire +3 more sources
Biochimie, 1985
The insulin receptor appears as a tetrameric glycoprotein consisting of two Mr 130,000 subunits (alpha), and two Mr 95,000 subunits (beta) in a disulfide-linked complex. Insulin bound to its specific cell surface receptors in its target cells leads to a complex array of molecular events resulting in insulin effects.
Hélène Gazzano +8 more
openaire +3 more sources
The insulin receptor appears as a tetrameric glycoprotein consisting of two Mr 130,000 subunits (alpha), and two Mr 95,000 subunits (beta) in a disulfide-linked complex. Insulin bound to its specific cell surface receptors in its target cells leads to a complex array of molecular events resulting in insulin effects.
Hélène Gazzano +8 more
openaire +3 more sources
Bioessays, 2013
Unraveling the molecular detail of insulin receptor activation has proved challenging, but a major advance is the recent determination of crystallographic structures of insulin in complex with its primary binding site on the receptor.
C. Ward, J. Menting, M. Lawrence
semanticscholar +1 more source
Unraveling the molecular detail of insulin receptor activation has proved challenging, but a major advance is the recent determination of crystallographic structures of insulin in complex with its primary binding site on the receptor.
C. Ward, J. Menting, M. Lawrence
semanticscholar +1 more source
Autoantibodies to insulin receptors
Molecular and Cellular Endocrinology, 1981In summary, these studies using antibodies to the insulin receptor have provided some new insights into the structure of the insulin receptor and the action of insulin itself. They suggest that most of insulin's actions are mediated through a common pathway and these can be initiated by interaction of ligands other than insulin with the insulin ...
C. Ronald Kahn, Emmanuel Van Obberghen
openaire +3 more sources
Insulin resistance: Review of the underlying molecular mechanisms
Journal of Cellular Physiology, 2018Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin. Insulin signaling is therefore critical for these tissues.
Habib Yaribeygi +3 more
semanticscholar +1 more source
1983
Publisher Summary This chapter focuses on insulin receptors in brain. It has been demonstrated by two different means that insulin from blood can reach the cerebrospinal fluid and then, presumably, the central nervous system tissue. While the access of circulating insulin is quite limited by the presence of the blood–brain barrier, the non-barrier ...
Michael J. Brownstein +3 more
openaire +3 more sources
Publisher Summary This chapter focuses on insulin receptors in brain. It has been demonstrated by two different means that insulin from blood can reach the cerebrospinal fluid and then, presumably, the central nervous system tissue. While the access of circulating insulin is quite limited by the presence of the blood–brain barrier, the non-barrier ...
Michael J. Brownstein +3 more
openaire +3 more sources