Results 221 to 230 of about 794,012 (351)

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Corrigendum to "Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation" [Mol Metab 18 (2018) 153-163]. [PDF]

Mol Metab
Gupta MK, De Jesus DF, Kahraman S, Valdez IA, Shamsi F, Yi L, Swensen AC, Tseng YH, Qian WJ, Kulkarni RN.   +9 more
europepmc   +1 more source

Estrogen and insulin synergistically promote endometrial cancer progression via crosstalk between their receptor signaling pathways

, 2019
Tian Wenyan, Fei Teng, Gao Jinping, Chao Gao, Guoyan Liu, Yanfang Zhang, Yu Shizhu, Wei Zhang, Wang Ying-mei, Fengxia Xue   +9 more
openalex   +2 more sources

Norepinephrine Promotes Microglia to Uptake and Degrade Amyloid β Peptide through Upregulation of Mouse Formyl Peptide Receptor 2 and Induction of Insulin-Degrading Enzyme [PDF]

, 2010
Yan Kong, Lingfei Ruan, Lihua Qian, Xiaolei Liu, Yingying Le   +4 more
openalex   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Heat shock protein DNAJA2 controls insulin signaling and glucose homeostasis by preventing spontaneous insulin receptor endocytosis. [PDF]

Nat Commun
Qin Y, Wu W, Lin K, Davis AJ, Huang Y.
europepmc   +1 more source

Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway [PDF]

, 2003
Yoshiaki Hirashima, Kaku Tsuruzoe, Shintaro Kodama, Motoyuki Igata, Tomomi Toyonaga, Kohjiro Ueki, C. Ronald Kahn, Eiichi Araki   +7 more
openalex   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Correlation between insulin receptor expression and tumor cell proliferation, recurrence and metastasis in well-differentiated pancreatic neuroendocrine neoplasms. [PDF]

Endocr Connect
Deng X, Niu T, Zheng M, Li J, Mao X, Chen D, Tang L, Liang X, Yang G, Ji M, Shi L, Wu W, Hu L, Lv X, Wang X, Shao C.   +15 more
europepmc   +1 more source

Direct comparison of the rates of internalization and degradation of covalent receptor-insulin complexes in 3T3-L1 adipocytes. Internalization of occupied receptors is not the rate-limiting step in receptor-hormone complex degradation.

, 1984
Brent C. Reed, K Glasted, Bonnie E. Miller   +2 more
openalex   +1 more source