Results 231 to 240 of about 744,871 (360)

Insulin receptor responsiveness governs TGFβ-induced hepatic stellate cell activation: Insulin resistance instigates liver fibrosis. [PDF]

FASEB J
Lee WH, Bates EA, Kipp ZA, Pauss SN, Martinez GJ, Blair CA, Hinds TD.   +6 more
europepmc   +1 more source

PRDM16 Reduces Cellular Senescence by Upregulating GSTM1

Advanced Science, EarlyView.
Cellular senescence drives aging and aging‐related organ disorders, yet PRDM16's role remains unexplored. This work uncovers that PRDM16 decreases significantly in aged organs, while its loss accelerates cellular senescence and aging‐related organ injury.
Qian Yuan, Yuting Zhu, Ben Tang, Yaru Xie, Mingcun Hu, Hua Su, Youhua Liu, Chun Zhang   +7 more
wiley   +1 more source

Autoantibodies Directed Against Insulin Receptor During the Course of Castleman Disease: A New Case Reaffirming Autoimmune Hypoglycemia as a Relapse Warning Signal. [PDF]

Eur J Case Rep Intern Med
Jannot X, Auclair M, Martinot M, Maazouzi A, Boutboul D, Vigouroux C, Dieudonné Y.   +6 more
europepmc   +1 more source

Targeting IGF1R Overcomes Armored and Cold Tumor Microenvironment and Boosts Immune Checkpoint Blockade in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
IGF1R is highly expressed in the armored & cold tumors, and collagen mediates IGF1R at the transcriptional and post‐translational levels to promote TNBC cell invasion and immune escape and to stabilize its own structure by interacting with the collagen receptor DDR1.
Mengyun Wan, Jie Mei, Yun Cai, Ji Zhou, Ningyi Xue, Ying Jiang, Yan Zhang, Jingjing Huang, Yichao Zhu   +8 more
wiley   +1 more source

Ubiquitinated CD36 sustains insulin-stimulated Akt activation by stabilizing insulin receptor substrate 1 in myotubes [PDF]

, 2018
Huang, Xiaoheng, Kong, Chen, Ren, Fangfang, Su, Xiong, Sun, Shishuo, Tan, Pengcheng, Zhang, Wei   +6 more
core   +2 more sources

Stimulation of glycosaminoglycan synthesis by somatomedin and insulin in rat chondrocytes via somatomedin receptors.

, 1984
KUMIKO ASAKAWA, Kazue Takano, Naomi Hizuka, Megumi Kogawa, KAZUO SHIZUME   +4 more
openalex   +2 more sources

Tacrolimus induces insulin receptor substrate 1 hyperphosphorylation and inhibits mTORc1/S6K1 cascade in HL7702 cells. [PDF]

World J Diabetes
Li HY, Wang Y, Ran M, Gao F, Zhu BY, Xiao HY, Xu C.   +6 more
europepmc   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

Insulin Receptor Substrate-2 Regulates the Secretion of Growth Factors in Response to Amino Acid Deprivation. [PDF]

Int J Mol Sci
Takahashi A, Furuta H, Nishi H, Kamei H, Takahashi SI, Hakuno F.   +5 more
europepmc   +1 more source

Cardiovascular Disease Meets Cancer: Exploring the Epidemiology in China and Homotherapy Targeting Intersectional Mechanisms

Advanced Science, EarlyView.
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang, Yujie Shan, Shihong Xu, Jing Wang, Meng Luo, Jiaojiao Zhou, Qishan Chen   +6 more
wiley   +1 more source