Results 231 to 240 of about 3,199,300 (285)

The Immunology of the Insulin Receptor

Immunological Communications, 1976
We have detected and characterized anti-insulin-receptor autoantibodies which circulate in several patients with insulin resistance diabetes. These antibodies are predominantly IgG and are polyclonal. They inhibit insulin binding to its receptor on a variety of tissues from widely separated species. Antibodies obtained from different patients appear to
David B. Jarrett, Jeffrey S. Flier, C. R. Kahn, Jesse Roth   +3 more
openaire   +3 more sources

Insulin Receptor and Insulin Action [PDF]

, 1990
Insulin generates a complex assay of biological responses in a variety of cell systems. The first step in insulin action is binding of the hormone to its specific cell surface receptor. This receptor is an oligomer consisting of two α-subunits with Mr 130 kDa, and twos-subunits with Mr 95 kDa; the different subunits are linked together by disulfide ...
E Van Obberghen, Robert Ballotti
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Insulin receptors and insulin signalling

1995
International ...
Taouis, Mohammed, Simon, J.
openaire   +6 more sources

Insulin Receptor Antibodies and Insulin Resistance

Southern Medical Journal, 1999
The presence of insulin receptor antibodies is a rare cause of insulin resistance. Patients usually have a combination of hyperglycemia, insulin resistance, acanthosis nigricans, and autoimmune features. We report a patient with systemic lupus erythematosus and severe insulin resistance due to insulin receptor antibodies.
Spencer J, Magsino Ch
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The Insulin Receptor Family

1994
The insulin receptor family in mammals includes the receptors for insulin, insulin-like growth factor I (IGF-I), and the insulin receptor-related receptor (IRR), a receptor whose sequence is homologous to the sequences of the other two receptors but whose ligand is unknown (Fig. 1) (1).
Kristina S. Kovacina, Richard A. Roth, Karen A. Seta   +2 more
openaire   +3 more sources

Insulin Receptor Autoimmunity and Insulin Resistance

Journal of Pediatric Endocrinology and Metabolism, 2008
The frequency of insulin receptor autoantibodies (IR-ab) was determined among adolescents and young adults with documented insulin resistance syndrome (IRS) with and without concomitant autoimmunity. The study population was comprised of 61 patients with obesity, acanthosis nigricans and insulin resistance (simple IRS); 12 with IRS and other autoimmune
Ping Zhou, Maria G. Vogiatzi, Noel K. Maclaren, Svetlana Ten, Svetlana Ten, Sunil Sinha, Sunil Sinha, Neesha Ramchandani, Neesha Ramchandani   +8 more
openaire   +2 more sources

Molecular and cellular aspects of the insulin-like growth factor I receptor.

Endocrine reviews, 1995
I. Introduction THE insulin-like growth factors (IGFs) and their receptors and binding proteins constitute a family of cellular modulators that play essential roles in the regulation of growth and development.
D. Leroith, H. Werner, D. Beitner‐Johnson, Andcharles T. Roberts   +3 more
semanticscholar   +1 more source

Role of brain insulin receptor in control of body weight and reproduction.

Science, 2006
Insulin receptors (IRs) and insulin signaling proteins are widely distributed throughout the central nervous system (CNS). To study the physiological role of insulin signaling in the brain, we created mice with a neuron-specific disruption of the IR gene
J. Brüning, D. Gautam, D. Burks, J. Gillette, M. Schubert, P. Orban, R. Klein, W. Krone, D. Müller-Wieland, C. Kahn   +9 more
semanticscholar   +1 more source

Mutations in the insulin receptor gene

Endocrine Reviews, 1992
I. Introduction THE insulin receptor is a cell surface glycoprotein that mediates the action of insulin upon target cells. The receptor was originally identified by its ability to bind the hormone (1–3). Over the past two decades, considerable progress has been made in defining the structure of the receptor molecule (4–7) as well as the biochemical ...
TAYLOR, SI, CAMA, A, ACCILI, D, BARBETTI, F, QUON, MJ, SIERRA, MD, SUZUKI, Y, KOLLER, E, LEVYTOLEDANO, R, WERTHEIMER, E, MONCADA, VY, KADOWAKI, H, KADOWAKI, T   +12 more
openaire   +6 more sources

Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.

Science, 1995
Sulfonylureas are a class of drugs widely used to promote insulin secretion in the treatment of non-insulin-dependent diabetes mellitus. These drugs interact with the sulfonylurea receptor of pancreatic beta cells and inhibit the conductance of adenosine
L. Aguilar-Bryan, C. Nichols, Sergio W. Wechsler, J. Clement, A. E. Boyd, G. González, H. Herrera-Sosa, Kimberly Nguy, J. Bryan, D. A. Nelson   +9 more
semanticscholar   +1 more source