Bayesian Analysis of Glucose Dynamics during the Oral Glucose Tolerance Test (OGTT) [PDF]
arXiv, 2020 In this paper, we propose a model of the dynamics of the blood glucose level during an Oral Glucose Tolerance Test (OGTT). This dynamic includes the action of insulin and glucagon in the glucose homeostasis process as the reaction of an oral stimulus.
arxiv
Cannabinoids Induce Pancreatic β-Cell Death by Directly Inhibiting Insulin Receptor Activation
Science Signaling, 2012 Activation of cannabinoid 1 receptors prevents insulin receptors from promoting β-cell survival in the pancreas. Death by Cannabinoids Cannabinoid receptors are located in the brain and in the periphery, where they mediate effects on mood, appetite ...
Wook Kim +7 more
semanticscholar +1 more source
An Artificial Insulin Receptor that Self-assembles and Works on a Gold Surface
ElectrochemistryA novel artificial insulin receptor was developed, that can self-assemble on a gold surface and alter its structure in response to insulin recognition via partial domains of the intrinsic insulin receptor.
Yusuke MURAI +9 more
doaj +1 more source
Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs
Frontiers in Endocrinology, 2017 A significant drawback of the exogenous administration of insulin to diabetics is the non-physiological profile of insulin action resulting in the insufficient suppression of hepatic glucose production, which is the main contributing factor to diabetic ...
Jiří Jiráček, Lenka Žáková
doaj +1 more source
Characterization of the norepinephrine-activation of adenylate cyclase suggests a role in memory affirmation pathways. Overexposure to epinephrine inactivates adenylate-cyclase,a causal pathway for stress-pathologies [PDF]
BioSystems 100 (2010) p. 87-93, 2010 Incubation with noradrenaline (norepinephrine) of isolated membranes of rat's brain corpus striatum and cortex, showed that ionic-magnesium (Mg2+) is required for the neurotransmitter activatory response of Adenylate Cyclase [ATP pyrophosphate-lyase (cyclizing), (EC 4.6.1.1)], AC.An Mg2+-dependent response to the activatory effects of adrenaline, and ...
arxiv
The beta secretase BACE1 regulates the expression of insulin receptor in the liver
Nature Communications, 2018 A soluble form of insulin receptor in human plasma has been previously reported. Here the authors demonstrate that insulin receptor is cleaved by BACE1 that can regulate biological active insulin receptor levels in a glucose concentration-dependent ...
Paul J. Meakin +11 more
doaj +1 more source
An Analytical Approach for Insulin-like Growth Factor Receptor 1 and Mammalian Target of Rapamycin Blockades in Ewing Sarcoma [PDF]
arXiv, 2015 We present preliminary results that quantify network robustness and fragility of Ewing sarcoma (ES), a rare pediatric bone cancer that often exhibits de novo or acquired drug resistance. By identifying novel proteins or pathways susceptible to drug targeting, this formalized approach promises to improve preclinical drug development and may lead to ...
arxiv
A model for insulin binding to the insulin receptor [PDF]
European Journal of Biochemistry, 1994 The affinities of a number of insulin analogues for the human insulin receptor, a truncated soluble form of the insulin receptor, and the human insulin‐like growth factor 1 receptor were determined. Insulin analogues with substitutions in the A13 or B17 positions were shown to have anomalous binding properties. This suggests that these positions, which
openaire +3 more sources
Robust Estimation of the Weighted Average Treatment Effect for A Target Population [PDF]
arXiv, 2018 The weighted average treatment effect (WATE) is a causal measure for the comparison of interventions in a specific target population, which may be different from the population where data are sampled from. For instance, when the goal is to introduce a new treatment to a target population, the question is what efficacy (or effectiveness) can be gained ...
arxiv
Journal of Biological Chemistry, 2002 Serine phosphorylation of insulin receptor substrate-1 (IRS-1) inhibits insulin signal transduction in a variety of cell backgrounds, which might contribute to peripheral insulin resistance.
Vincent Aguirre +5 more
semanticscholar +1 more source