Results 81 to 90 of about 727,371 (257)

Receptor-mediated targeting of magnetic nanoparticles using insulin as a surface ligand to prevent endocytosis [PDF]

, 2003
Superparamagnetic iron oxide nanoparticles have been used for many years as magnetic resonance imaging contrast agents or in drug delivery applications.
Berry, C.C., Curtis, A.S.G., Gupta, A.K., Gupta, M.   +3 more
core   +1 more source

The Insulin/IGF system in colorectal cancer development and resistance to therapy

Frontiers in Oncology, 2015
The Insulin/Insulin-like growth factor (IGF) system is a major determinant in the pathogenesis and progression of colorectal cancer (CRC). Indeed, several components of this signaling network including Insulin, IGF-1, IGF-2, the IGF-Binding Proteins, the
Paolo Giovanni Vigneri, Elena eTirrò, Maria Stella ePennisi, Michele eMassimino, Stefania eStella, Chiara eRomano, Livia eManzella   +6 more
doaj   +1 more source

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice [PDF]

, 2003
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension.
Aubert, Busetto, Butz, Christopher J. Kenyon, Contreras, Cowley, De la Sieera, Folli, Frederich, Hiroaki Masuzaki, Hiroshi Shinyama, Hiroshi Yamamoto, Janice M. Paterson, Jeffrey S. Flier, Joel K. Elmquist, John J. Mullins, Johnson, Jonathan R. Seckl, Kopelman, Lalouel, Llorens-Cortes, Massiera, Masuzaki, Matthew G.F. Sharp, Miller, Mills, Montani, Morton, Nicholas M. Morton, O’Brien, Pradevand, Pratt, Rotimi, Stepp, Stewart Fleming, Villiquette, Walker, Weinburger, Williams, Yamamoto   +39 more
core   +5 more sources

The beta secretase BACE1 regulates the expression of insulin receptor in the liver

Nature Communications, 2018
A soluble form of insulin receptor in human plasma has been previously reported. Here the authors demonstrate that insulin receptor is cleaved by BACE1 that can regulate biological active insulin receptor levels in a glucose concentration-dependent ...
Paul J. Meakin, Anna Mezzapesa, Eva Benabou, Mary E. Haas, Bernadette Bonardo, Michel Grino, Jean-Michel Brunel, Christèle Desbois-Mouthon, Sudha B. Biddinger, Roland Govers, Michael L. J. Ashford, Franck Peiretti   +11 more
doaj   +1 more source

An Artificial Insulin Receptor that Self-assembles and Works on a Gold Surface

Electrochemistry
A novel artificial insulin receptor was developed, that can self-assemble on a gold surface and alter its structure in response to insulin recognition via partial domains of the intrinsic insulin receptor.
Yusuke MURAI, Hiroya SATO, Hayate INOUE, Eiji ARITA, Yoshiaki YAGUCHI, Takenori ISHIDA, Takeshi IKEDA, Ryuichi HIROTA, Akio KURODA, Hisakage FUNABASHI   +9 more
doaj   +1 more source

Computational insights into the allosteric behavior of mini proinsulin driven by C peptide mobility

Scientific Reports
The production of recombinant insulin remains challenging, particularly in enhancing refolding efficiency and bioactivity. Mini-proinsulin analogs, which involve reducing the length of the C-peptide, offer potential improvements in insulin production ...
Esra Ayan
doaj   +1 more source

Immunohistochemical analysis of insulin‐like growth factor I, insulin‐like growth factor I receptor and insulin‐like growth factor II in endometriotic tissue and endometrium

Acta Obstetricia et Gynecologica Scandinavica, 1997
Background. The purpose of this study was to investigate unprecedentedly immunohistochemical localization of insulin‐like growth factor I, insulin‐like growth factor I receptor and insulin‐like growth factor II in endometriotic tissue, and to compare ...
Shiuh Y. Chang, Yat‐Sen Ho
doaj   +1 more source

Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis

EBioMedicine, 2016
Low-density lipoprotein receptor-related protein-1 (LRP1) is a multifunctional uptake receptor for chylomicron remnants in the liver. In vascular smooth muscle cells LRP1 controls reverse cholesterol transport through platelet-derived growth factor ...
Yinyuan Ding, Xunde Xian, William L. Holland, Shirling Tsai, Joachim Herz   +4 more
doaj   +1 more source

Agonism and Antagonism at the Insulin Receptor

PLoS ONE, 2012
Insulin can trigger metabolic as well as mitogenic effects, the latter being pharmaceutically undesirable. An understanding of the structure/function relationships between insulin receptor (IR) binding and mitogenic/metabolic signalling would greatly facilitate the preclinical development of new insulin analogues.
Knudsen, Louise, Hansen, Bo Falck, Jensen, Pia, Pedersen, Thomas Åskov, Vestergaard, Kirsten, Schäffer, Lauge, Blagoev, Blagoy, Oleksiewicz, Martin B, Kiselyov, Vladislav V, De Meyts, Pierre Marcel Joseph   +9 more
openaire   +6 more sources

A Receptor Mechanism for the Inhibition Of Insulin Release by Epinephrine in Man* [PDF]

, 1967
Daniel Porte
openalex   +1 more source