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Pathophysiology of Prediabetes Hyperinsulinemia and Insulin Resistance in the Cardiovascular System [PDF]

Biomedicines
Hyperinsulinemia refers to an elevated level of circulating insulin (80 and 100 µU/mL), often leading to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes (T2D).
Ghassan Bkaily, Ashley Jazzar, Amira Abou-Aichi, Danielle Jacques   +3 more
doaj   +2 more sources

Insulin resistance causes inflammation in adipose tissue [PDF]

Journal of Clinical Investigation, 2018
Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue, obesity-mediated insulin resistance correlates with the accumulation of proinflammatory macrophages and inflammation.
Anne Christin Meyer-Gerspach, Bettina Woelnerhanssen, Cho, Christoph Beglinger, Diana Weissenberger, Gene Ontology, Irina C. Frei, Jerome A. Meier, Marco Colombi, Marta M. Swierczynska, Michael N. Hall, Mitsugu Shimobayashi, Morley, Nicolas Clement, Ofei, Paquot, Paul Jenö, Ralph Peterli, Rosen, Suzette Moes, Tang, Verena Albert, Wascher   +22 more
core   +3 more sources

Use of the SGLT2 inhibitor canagliflozin for control of refractory equine hyperinsulinemia and laminitis [PDF]

Open Veterinary Journal, 2022
Background: Hyperinsulinemia associated with pituitary pars intermedia dysfunction (PPID) and/or equine metabolic syndrome (EMS) is well documented to put horses at high risk of laminitis.
Eleanor M. Kellon, Kathleen M. Gustafson
doaj   +1 more source

Mifepristone reduces insulin resistance in patient volunteers with adrenal incidentalomas that secrete low levels of cortisol : a pilot study [PDF]

, 2013
Background: Incidental adrenal masses are commonly detected during imaging for other pathologies. 10% of the elderly population has an ‘adrenal incidentaloma’, up to 20% of these show low-grade autonomous cortisol secretion and 60% of patients with ...
Chadarevian, Rita, Eastell, R. (Richard), Newell-Price, John, Randeva, Harpal S., Ross, Richard J. M.   +4 more
core   +24 more sources

Gut microbial carbohydrate metabolism contributes to insulin resistance

Nature, 2023
Faecal carbohydrates, particularly host-accessible monosaccharides, are increased in individuals with insulin resistance and are associated with microbial carbohydrate metabolisms and host inflammatory cytokines.
T. Takeuchi, Tetsuya Kubota, Yumiko Nakanishi, H. Tsugawa, W. Suda, A. T. Kwon, J. Yazaki, Kazutaka Ikeda, Shino Nemoto, Yoshiki Mochizuki, T. Kitami, K. Yugi, Yoshiko Mizuno, N. Yamamichi, Tsutomu Yamazaki, Iseki Takamoto, N. Kubota, T. Kadowaki, E. Arner, Piero Carninci, O. Ohara, Makoto Arita, M. Hattori, S. Koyasu, Hiroshi Ohno   +24 more
semanticscholar   +1 more source

Hypertriglyceridemia in equines with refractory hyperinsulinemia treated with SGLT2 inhibitors

Open Veterinary Journal, 2023
Background: Sodium-Glucose CoTransporter-2 [SGLT2] inhibitors, the -flozin group of drugs, which block glucose reuptake in the renal proximal tubule, are being increasingly used off-label to treat horses with refractory hyperinsulinemia. After two years
Eleanor M. Kellon, Kathleen M. Gustafson
doaj   +1 more source

Possible dysmetabolic hyperferritinemia in hyperinsulinemic horses [PDF]

Open Veterinary Journal, 2019
Background: Hyperinsulinemia associated with equine metabolic syndrome (EMS) and pituitary pars intermedia dysfunction (PPID) is a risk factor for laminitis.
Eleanor M. Kellon, Kathleen M. Gustafson
doaj   +1 more source

Trends in insulin resistance: insights into mechanisms and therapeutic strategy

Signal Transduction and Targeted Therapy, 2022
The centenary of insulin discovery represents an important opportunity to transform diabetes from a fatal diagnosis into a medically manageable chronic condition.
Mengwei Li, Xiaowei Chi, Ying Wang, Sarra Setrerrahmane, Wenwei Xie, Hanmei Xu   +5 more
semanticscholar   +1 more source

Clinical analysis of insulin resistance in liver cirrhosis patients

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To investigate the insulin resistance in liver cirrhosis patients.Methods·Patients with liver cirrhosis from Xinhua Hospital,Shanghai Jiao Tong University School of Medicine in 2013‒2017 were retrospectively assessed.
SHI Cuicui, ZHANG Jie, HUANG Heming, SANG Yuer, LI Guangming   +4 more
doaj   +1 more source

The Effect of a Maternal Mediterranean Diet in Pregnancy on Insulin Resistance is Moderated by Maternal Negative Affect. [PDF]

, 2020
There is inconsistent evidence that healthy dietary interventions can effectively mitigate the risk of adverse outcomes associated with elevated insulin resistance in pregnancy, suggesting that other moderating factors may be at play.
Buss, Claudia, Entringer, Sonja, Lindsay, Karen L, Wadhwa, Pathik D   +3 more
core   +1 more source