Results 101 to 110 of about 4,252,621 (405)

Early postnatal caloric restriction protects adult male intrauterine growth-restricted offspring from obesity. [PDF]

, 2012
Postnatal ad libitum caloric intake superimposed on intrauterine growth restriction (IUGR) is associated with adult-onset obesity, insulin resistance, and type 2 diabetes mellitus (T2DM).
Dai, Yun, Devaskar, Sherin U, Garg, Meena, Shin, Bo-Chul, Stout, David, Thamotharan, Manikkavasagar, Thamotharan, Shanthie   +6 more
core   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Does Omega-3 Fatty Acid Supplementation Have Beneficial Effects on Plasma Homocysteine, Insulin Resistance and Lipid Profile of Type 2 Diabetic Patients? A Randomized Clinical Trial

Journal of Nutrition and Food Security, 2018
Background: This study was conducted to determine the effects of n-3 PUFAs supplementation on plasma homocysteine (Hcy) level, lipid profile and insulin resistance in patients with type 2 diabetes (T2D).
Faezeh Poursoleiman, Hassan Mozaffari-Khosravi, Akram Naghdipour Biregani   +2 more
doaj  

β-Cell failure in type 2 diabetes: a case of asking too much of too few? [PDF]

, 2013
The islet in type 2 diabetes (T2DM) is characterized by a deficit in β-cells, increased β-cell apoptosis, and extracellular amyloid deposits derived from islet amyloid polypeptide (IAPP). In the absence of longitudinal studies, it is unknown if the low β-
Butler, Peter C, Costes, Safia, Gurlo, Tatyana, Langen, Ralf, Matveyenko, Aleksey V   +4 more
core   +1 more source

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux.

Journal of Clinical Investigation, 2016
Insulin resistance arises when the nutrient storage pathways evolved to maximize efficient energy utilization are exposed to chronic energy surplus. Ectopic lipid accumulation in liver and skeletal muscle triggers pathways that impair insulin signaling ...
V. Samuel, G. Shulman
semanticscholar   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study. [PDF]

, 2011
ObjectiveDiabetic and prediabtic states, including insulin resistance, fasting hyperglycemia, and hyperinsulinemia, are associated with metabolic dysregulation.
Au, Rhoda, Beiser, Alexa S, Debette, Stephanie, Decarli, Charles, Fox, Caroline S, Himali, Jayandra J, Seshadri, Sudha, Tan, Zaldy S, Vasan, Ramachandran S, Wolf, Philip A   +9 more
core   +2 more sources

Insulin Resistance and Atherosclerosis: Implications for Insulin Sensitizing Agents.

Endocrine reviews, 2019
Type 2 diabetic patients are at high risk for macrovascular complications, which represent the major cause of mortality. Despite effective treatment of established cardiovascular (CV) risk factors (dyslipidemia, hypertension, procoagulant state), there ...
A. Di Pino, R. DeFronzo
semanticscholar   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Insulin Resistance and Atherosclerosis [PDF]

Endocrinology and Metabolism Clinics of North America, 2008
Insulin resistance characterizes type 2 diabetes and the metabolic syndrome, disorders associated with an increased risk of death due to macrovascular disease. In the past few decades, research from both the basic science and clinical arenas has enabled evidence-based use of therapeutic modalities such as statins and angiotensin-converting enzyme ...
Clay F. Semenkovich, Manu V. Chakravarthy, Babak Razani   +2 more
openaire   +3 more sources