Results 111 to 120 of about 951,131 (359)

The Effects of Engeletin on Insulin Resistance Induced in Human HepG2 Liver Cells

Current Issues in Molecular Biology
In this study, we aimed to investigate the effect of Engeletin (ENG) on insulin resistance and the associated oxidative cell damage in human HepG2 liver cells. The cells were grown in a cell culture medium, and insulin resistance was induced.
Erdem Toktay, Secil Nazife Parlak, Tugba Kavas, Harun Un, Rustem Anıl Ugan, Muhammed Yayla   +5 more
doaj   +1 more source

Insulin Resistance: From Theory To Practice [PDF]

, 2006
Insulin resistance is at the core of the well recognised metabolic syndrome and possibly many other ailments commonly seen in the modern society. While the quantification of insulin resistance remains a difficult task, the problems associated with it are
Kakkilaya Bevinje, Dr. Srinivas
core   +1 more source

Insulin Resistance in PCOS

Endocrine, 2006
Polycystic ovary syndrome (PCOS) is the commonest endocrinopathy affecting women of reproductive age, manifested with a variety of clinical signs, none of which is pathognomonic. The association of insulin resistance and reproductive abnormalities with clinical hyperandrogenism in a woman was first demonstrated by Achard and Thiers in the "diabetes of ...
openaire   +4 more sources

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Nutritional modulation of insulin resistance [PDF]

, 2012
Insulin resistance has been proposed as the strongest single predictor for the development of Type 2 Diabetes (T2DM). Chronic oversupply of energy from food, together with inadequate physical activity, have been recognized as the most relevant factors ...
Weickert, Martin O.
core   +3 more sources

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration

Advanced Functional Materials, EarlyView.
A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo, Chiara Arrigoni, Tobias Faehling, Antonietta Verrillo, Viviana Secci, Thomas G. P. Grünewald, Giuseppe Talò, Alexandra Kummer, Jorge Gonzalez, Vincenzo De Rosa, Christian Candrian, Andrea Barbero, Florencia Cidre‐Aranaz, Matteo Moretti   +13 more
wiley   +1 more source

Compliance with behavioral guidelines for diet, physical activity and sedentary behaviors is related to insulin resistance among overweight and obese youth [PDF]

, 2011
Background Overweight and obesity are established risk factors for insulin resistance in youth. A number of behavioral recommendations have been publicized with the goal of improving glycemic control.
Gregory J Norman, James F Sallis, Jeannie S Huang, Karen J Calfas, Kevin Patrick, Michael Gottschalk   +5 more
core   +3 more sources

Bioorthogonal Engineering of Cellular Microenvironments Using Isonitrile Ligations

Advanced Functional Materials, EarlyView.
Highly selective chemistries are required for fabrication and post‐cross–linking modification of cell‐encapsulating hydrogels used in tissue engineering applications. Isonitrile ligation reactions represent a promising class of bioorthogonal chemistries for engineering hydrogel‐based cellular microenvironments. Isonitrile‐based hydrogels are stable and
Ping Zhou, Lauren Brown, Christopher M. Madl   +2 more
wiley   +1 more source

11 beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle [PDF]

, 2009
OBJECTIVE: Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown.
Morgan, S. A., Sherlock, M., Gathercole, L.L, Lavery, Gareth G., Lenaghan, C., Bujalska, I.J, Laber, D., Yu, A., Convey, G., Mayers, R., Hegyi, K., Sethi, J. K., Stewart, P M, Smith, D. M., Tomlinson, J W   +14 more
core   +4 more sources

Imaging of Lipid Droplets in Living Cells and Mice with Metabolic Dysfunction‐Associated Steatotic Liver Disease via a Galactose‐Modified Supramolecular Near‐Infrared Fluorescent Glycoprobe

Advanced Functional Materials, EarlyView.
A galactose‐modified supramolecular near‐infrared (NIR) glycoprobe, TCF‐FBN@Gal‐BSA, enables targeted delivery to the liver through the asialoglycoprotein receptor (ASGPR) and facilitates liver‐targeting fluorescence visualization of lipid droplets (LDs) in metabolic dysfunction‐associated steatotic liver disease (MASLD) mice.
Han‐Min Wang, Lei Dong, Qiu‐Lian Hao, Lu‐Lu Sun, Xin‐Rong Li, Yu‐Wei Yuan, Ming‐Ye Tang, Jin Gong, Yi Zang, Jia Li, Tony D. James, Xiao‐Peng He, Hai‐Hao Han   +12 more
wiley   +1 more source