Results 111 to 120 of about 797,794 (382)

Association between the Time of Length since Smoking Cessation and Insulin Resistance in Asymptomatic Korean Male Ex-Smokers

Journal of Diabetes Research, 2017
Aim. Smoking is a major risk factor for diabetes mellitus, mainly due to decreased insulin secretion and increased insulin resistance. However, there has been little research on the effects of smoking cessation period on changes in insulin resistance. In
Ko-Woon Kim, Sung-Goo Kang, Sang-Wook Song, Na-Rae Kim, Jun-Seung Rho, Yun-Ah Lee   +5 more
doaj   +1 more source

Pancreatic beta-cell insulin signaling in genetic and dietary models of obesity and insulin resistance [PDF]

, 2019
Type 2 Diabetes Mellitus (T2DM) is a heterogeneous metabolic disease characterized by elevated blood glucose levels that has reached pandemic proportions.
Paschen, Meike
core   +1 more source

The Energy Sensor AMPK: Adaptations to Exercise, Nutritional and Hormonal Signals [PDF]

Spiegelman B. Hormones, Metabolism and the Benefits of Exercise, Hormones, Metabolism and the Benefits of Exercise, Springer, pp.13-24, 2018, Research and Perspectives in Endocrine Interactions, 978-3-319-72789-9, 2019
To sustain metabolism, intracellular ATP concentration must be regulated within an appropriate range. This coordination is achieved through the function of the AMP-activated protein kinase (AMPK), a cellular "fuel gauge" that is expressed in essentially all eukaryotic cells as heterotrimeric complexes containing catalytic $\alpha$ subunits and ...
arxiv  

Statistical Evaluation of Medical Tests [PDF]

arXiv, 2020
In this review, we present an overview of the main aspects related to the statistical evaluation of medical tests for diagnosis and prognosis. Measures of diagnostic performance for binary tests, such as sensitivity, specificity, and predictive values, are introduced, and extensions to the case of continuous-outcome tests are detailed. Special focus is
arxiv  

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

Advanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu, Jueun Kim, Dae‐Hyun Kim, Sewoom Baek, Suji Park, Seyong Chung, Hak‐Joon Sung   +6 more
wiley   +1 more source

Insulin resistance causes inflammation in adipose tissue [PDF]

, 2018
Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue, obesity-mediated insulin resistance correlates with the accumulation of proinflammatory macrophages and inflammation.
Anne Christin Meyer-Gerspach, Bettina Woelnerhanssen, Cho, Christoph Beglinger, Diana Weissenberger, Gene Ontology, Irina C. Frei, Jerome A. Meier, Marco Colombi, Marta M. Swierczynska, Michael N. Hall, Mitsugu Shimobayashi, Morley, Nicolas Clement, Ofei, Paquot, Paul Jenö, Ralph Peterli, Rosen, Suzette Moes, Tang, Verena Albert, Wascher   +22 more
core   +2 more sources

Engineering Novel DNA Nanoarchitectures for Targeted Drug Delivery and Aptamer Mediated Apoptosis in Cancer Therapeutics

Advanced Functional Materials, EarlyView.
Designer DNA Architecture‐templated Drug Conjugates (DDA‐DCs) are comprised of a DNA nanomaterial decorated with multiple drug‐loaded DNA aptamers. DDA‐DCs use a combination of multiple aptamer types, each recognizing a different membrane protein to achieve precise targeting of cancer cells.
Abhisek Dwivedy, Dhyanesh Baskaran, Gaurav Sharma, Wei Hong, Dhanush Gandavadi, Abhichart Krissanaprasit, Joonsu Han, Yusheng Liu, Zack Zimmers, Tshepo Mafokwane, Ichrak Hayah, Neha Chauhan, Mengxi Zheng, Sherwood Yao, Keith Fraser, John S. Decker, Xiaohe Jin, Hua Wang, Adam D. Friedman, Xing Wang   +19 more
wiley   +1 more source

Mechanisms and Linkage of Insulin Signaling, Resistance, and Inflammation [PDF]

المجلة العراقية للصيدلة
Background: Chronic inflammation is responsible for low insulin sensitivity, making obesity a major risk factor for developing insulin resistance, type 2 diabetes mellitus, and metabolic syndrome.
khalil Amjad Hadid, Fawaz Alassaf, Mohammed Abed   +2 more
doaj   +1 more source

Reinforcement Learning-Based Adaptive Insulin Advisor for Individuals with Type 1 Diabetes Patients under Multiple Daily Injections Therapy [PDF]

arXiv, 2019
The existing adaptive basal-bolus advisor (ABBA) was further developed to benefit patients under insulin therapy with multiple daily injections (MDI). Three different in silico experiments were conducted with the DMMS.R simulator to validate the approach of combined use of self-monitoring of blood glucose (SMBG) and insulin injection devices, e.g ...
arxiv  

Insulin Resistance in PCOS

Endocrine, 2006
Polycystic ovary syndrome (PCOS) is the commonest endocrinopathy affecting women of reproductive age, manifested with a variety of clinical signs, none of which is pathognomonic. The association of insulin resistance and reproductive abnormalities with clinical hyperandrogenism in a woman was first demonstrated by Achard and Thiers in the "diabetes of ...
openaire   +4 more sources