Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes. [PDF]
, 1992 Ai Ogawa +6 more
openalex +1 more source
Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice
Advanced Science, EarlyView.Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia +29 more
wiley +1 more source
Injectable BMSC‐Based Extracellular Matrix‐Mimicking Microtissue for Myocardial Infarction Repair
Advanced Science, EarlyView.A novel injectable biomimetic extracellular matrix scaffold (JLSV) is designed for enhanced delivery of bone marrow‐derived mesenchymal stem cells (BMSCs). By utilizing janus basic nanotubes, laminin, stromal‐derived factor‐1 alpha, and vascular endothelial growth factor, this innovative JLSV–BMSC microtissue shows promise in myocardial infarction ...
Lina Yao +7 more
wiley +1 more source
Association of Students' Nutritional Behaviors with Insulin Resistance and Body Measurements. [PDF]
Med Sci MonitDağaşan T +4 more
europepmc +1 more source
Insulin resistance is an important determinant of left ventricular mass in the obese. [PDF]
, 1993 Zion Sasson +3 more
openalex +1 more source
PRDM16 Reduces Cellular Senescence by Upregulating GSTM1
Advanced Science, EarlyView.Cellular senescence drives aging and aging‐related organ disorders, yet PRDM16's role remains unexplored. This work uncovers that PRDM16 decreases significantly in aged organs, while its loss accelerates cellular senescence and aging‐related organ injury.
Qian Yuan +7 more
wiley +1 more source
Detection of mutations in the insulin receptor gene in patients with insulin resistance by analysis of single-stranded conformational polymorphisms [PDF]
, 1992 Hyungjun Kim +12 more
openalex +1 more source
Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism
Advanced Science, EarlyView.Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang +4 more
wiley +1 more source
Advanced Science, EarlyView.TBC1D22B, a Golgi‐localized RabGAP linked to poor prognosis in breast cancer, inhibits ER‐to‐Golgi transport via RAB1B inactivation. This disrupts secretion, drives oncogenic transcriptional reprogramming, and promotes tumor growth. These findings indicate that TBC1D22B connects membrane trafficking to transcriptional control and cancer progression ...
Flavia Martino +16 more
wiley +1 more source
Prediction Model for Insulin Resistance and Implications for MASLD in Youth: A Novel Marker, the Pediatric Insulin Resistance Assessment Score. [PDF]
Yonsei Med JSong K +8 more
europepmc +1 more source