Results 201 to 210 of about 861,807 (357)

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

Advanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen   +13 more
wiley   +1 more source

Establishment and Evaluation of HepG2 Cell Insulin Resistance Model. [PDF]

Diabetes Metab Syndr Obes
Meng Z, Han Y, Ruan L, Xu C, Zhang M, Liu H.   +5 more
europepmc   +1 more source

Growth hormone, insulin-like growth factor-1 and insulin resistance in cirrhosis [PDF]

, 1994
E Shmueli
openalex   +1 more source

Engineered RGD‐Treg‐Exos Targeted Delivery of miR‐218‐5p to Activate Mitophagy and Attenuate Podocyte Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
Tregs‐Exos deliver miR‐218‐5p to increase mitophagy in podocytes by inhibiting the TNC/TLR4/SRC/FUNDC1 pathway. RGD‐Treg‐Exos, engineered to express RGD peptides on the membrane surface, bind to integrins on the surface of podocytes and effectively target podocytes for the delivery of miR‐218‐5p, which increases mitophagy and reduces apoptosis in ...
Zhaochen Guo, Shaohui Gao, Ziyue Wang, Zige Chen, Jinglei Chen, Aiping Duan, Feng Xu, Qinger Wang, Weisong Qin, Caihong Zeng, Zhihong Liu, Hao Bao   +11 more
wiley   +1 more source

How much insulin resistance in polycystic ovary syndrome? Comparison of HOMA-IR and insulin resistance (Belfiore) index models

Archives of Medical Science, 2019
Krzysztof C. Lewandowski, Elżbieta Skowrońska-Jóźwiak, Katarzyna Łukasiak, Katarzyna Gałuszko, Aleksandra Dukowicz, Magdalena Cedro, Andrzej Lewiński   +6 more
doaj   +1 more source

Insulin resistance as a mediator between obesity and periodontitis risk. [PDF]

BMC Oral Health
Jiang S, Liang C, Jing J, Wang M, Sun H, Zuo B.   +5 more
europepmc   +1 more source

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source

Lipid Subclasses Differentiate Insulin Resistance by Triglyceride-Glucose Index. [PDF]

Metabolites
Naja K, Anwardeen N, Albagha O, Elrayess MA.   +3 more
europepmc   +1 more source

Hyperinsulinemia and Insulin Resistance: Physiology to Clinical Implications [PDF]

, 1992
Mal R. Homan
openalex   +1 more source

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source