Results 241 to 250 of about 3,202,592 (310)

Insulin resistance is associated with mammary mitochondrial dysfunction at the onset of human lactation. [PDF]

J Clin Invest
Meng X, Elajnaf T, Rostom H, Ma M, Furst A, Davies BR, Honess IR, Pandey G, Furigo IC, Doig CL, Martin Carli JF, Thakker RV, Bode L, Johnson KE, Hannan FM.   +14 more
europepmc   +1 more source

Astrocyte‐Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis

Advanced Science, EarlyView.
During kainic acid‐induced epileptogenesis, astrocyte‐associated ATP‐binding cassette transporter A1 (ABCA1) and apolipoprotein E (APOE) responses accompany ectopic neurons and exploratory lipid alterations. In separate cohorts, bexarotene pretreatment and treatment on days 14–21 are associated with fewer ectopic hilar neurons and lower chronic seizure
Lu Chen, Xiao‐Rui Shi, Jia‐Yi Chen, Ying‐Ting Wang, Le Du, Yang Ni, Jun‐Min Chen, An‐Chen Guo, Qian Wu, Jian‐Ping Wu, Qun Wang   +10 more
wiley   +1 more source

Cardiometabolic Risk Clustering and Surrogate Markers of Insulin Resistance in Adolescents. [PDF]

Int J Appl Basic Med Res
Chhabra N, Chhabra S, Patil R, Kukreja S.   +3 more
europepmc   +1 more source

The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype

Advanced Science, EarlyView.
A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan, Zhengyao Zhai, Chuyu Jing, Wei Zhang, Wenjuan Tian, Yulan Ren   +5 more
wiley   +1 more source

Adipose Tissue Palmitoylation Cycling Mediates Insulin Resistance and Preservation of β-Cell Function in Mice. [PDF]

Diabetes
Dong G, Spyropoulos G, Adak S, Zhang Q, Zhang W, Speck SL, Maimaituxun G, Kleiboeker B, Lodhi IJ, Wei X, Semenkovich CF.   +10 more
europepmc   +1 more source

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

Advanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola, Keun‐Young Kim, Ziyao Shen, Guy A. Perkins, Muna Poudel, Yoonjin Lim, Hyejeong Choi, Soo‐Ho Choi, Mark H. Ellisman, Robert N. Weinreb, Won‐Kyu Ju   +10 more
wiley   +1 more source

Therapeutic Potential of Gene-Modified MSC-Exos in Insulin Resistance: Mitochondrial Crosstalk and miRNA Regulation. [PDF]

J Cell Mol Med
Jia Q, Li B, Xing Y, Zhang Y, Gao B, Li X, Ha X.   +6 more
europepmc   +1 more source

Acinar‐Derived Organoids Reveal Stage‐Specific Control of Acinar Plasticity

Advanced Science, EarlyView.
An acinar‐derived organoid system maintains adult pancreatic acinar identity ex vivo, converts it along an ordered acinar‐to‐ductal‐like trajectory, and then partially restores it. Each transition carries its own signal requirement, with EGF/EGFR initiating conversion and a staged glucocorticoid–IGF1R switch driving redifferentiation.
Yongfei Hou, Siyu Li, Chunying Li, Zhifan Lin, Dan He, Li Yang, Liping Fu, Qianyue Zhang, Tianping Zhou, Yao Yao, Xiaolei Yin   +10 more
wiley   +1 more source

Role of insulin resistance in atherosclerosis: underlying mechanisms and emerging stem cell-based therapeutic strategies. [PDF]

Front Med (Lausanne)
Zhang Q, Chen Y, Wang D, Pereira S, Kurtyk MJB.   +4 more
europepmc   +1 more source