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Insulin resistance and insulin sensitizing agents [PDF]
Metabolism: Clinical and Experimental, 2021 Insulin resistance is a common feature of obesity and type 2 diabetes, but novel approaches of diabetes subtyping (clustering) revealed variable degrees of insulin resistance in people with diabetes. Specifically, the severe insulin resistant diabetes (SIRD) subtype not only exhibits metabolic abnormalities, but also bears a higher risk for ...
Michael Roden, Lucia Mastrototaro
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Insulins for Insulin Resistance
Annals of Internal Medicine, 1981Excerpt To the editor: Dr. Galloway (1) notes in his comment on our article "U-500 Insulin in the Treatment of Antibody-Mediated Insulin Resistance" (2) that we did not compare equivalent doses of ...
D M, Nathan, L, Axelrod
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Insulin Resistance and Insulin Sensitizers
Hormone Research in Paediatrics, 2001Insulin resistance is a key factor in the pathogenesis of type 2 diabetes mellitus and a co-factor in the development of dyslipidaemia, hypertension and atherosclerosis. The causes of insulin resistance include factors such as obesity and physical inactivity, and there may also be genetic factors.
M, Stumvoll, H, Häring
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Nursing Standard, 2003
Insulin resistance is one of the most important causes of premature death in developed countries (Turtle 2000). In this article, Alison Jeffery examines the basic pathology of insulin resistance and its effect on metabolic health. The role of the nurse is discussed in relation to prevention, health promotion and drug treatments for the management of ...
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Insulin resistance is one of the most important causes of premature death in developed countries (Turtle 2000). In this article, Alison Jeffery examines the basic pathology of insulin resistance and its effect on metabolic health. The role of the nurse is discussed in relation to prevention, health promotion and drug treatments for the management of ...
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Hexosamines and Insulin Resistance
Diabetes, 1996Glucose is an important regulator of cell growth and metabolism. Thus, it is likely that some of the adverse effects of hyperglycemia are reflections of normal regulation by abnormal concentrations of glucose. How the cell senses glucose, however, is still incompletely understood.
D A, McClain, E D, Crook
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Immunologic insulin resistance
Diabetes, 1978The efficacy of sulfated beef insulin for plasma glucose control in 35 patients with immunologie insulin resistance was studied. Patients were on a mean dose of 550 U./day (range 200–2,000) of U-500 regular beef insulin. Mean maximum 125I-insulin-binding capacity was 191 mU./ml. serum (range 13–1,080).
J K, Davidson, D W, DeBra
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Insulin Receptors and Insulin Resistance
Annual Review of Medicine, 1983Resistance to the action of insulin plays a central role in many important disease states, including diabetes and obesity. Many insights into the mechanism and significance of insulin resistance in these and other disorders have followed upon our expanding knowledge regarding insulin receptors.
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Insulin, Cation Metabolism and Insulin Resistance
Journal of Basic and Clinical Physiology and Pharmacology, 1998There is considerable evidence that insulin and insulin-like growth factors regulate a number of important physiological functions in a variety of tissues, some not considered to be classically insulin sensitive. Impaired biological responses to insulin and related insulin-like growth factors are referred to as insulin resistance.
J R, Sowers, B, Draznin
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Glycosphingolipids and Insulin Resistance
2011Glycosphingolipids are structural membrane components, residing largely in the plasma membrane with their sugar-moieties exposed at the cell's surface. In recent times a crucial role for glycosphingolipids in insulin resistance has been proposed. A chronic state of insulin resistance is a rapidly increasing disease condition in Western and developing ...
Aerts, J.M. +15 more
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Insulin resistance and hypertension
Molecular and Cellular Endocrinology, 1990Diminished insulin (Ins) sensitivity is a characteristic feature of various pathological conditions such as the cardiometabolic syndrome, Type 2 diabetes, and hypertension. Persons with essential hypertension are more prone than normotensive persons to develop diabetes, and this propensity may reflect decreased ability of Ins to promote relaxation and
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