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Immunologic insulin resistance
Diabetes, 1978The efficacy of sulfated beef insulin for plasma glucose control in 35 patients with immunologie insulin resistance was studied. Patients were on a mean dose of 550 U./day (range 200–2,000) of U-500 regular beef insulin. Mean maximum 125I-insulin-binding capacity was 191 mU./ml. serum (range 13–1,080).
J K, Davidson, D W, DeBra
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Glycosphingolipids and Insulin Resistance
2011Glycosphingolipids are structural membrane components, residing largely in the plasma membrane with their sugar-moieties exposed at the cell's surface. In recent times a crucial role for glycosphingolipids in insulin resistance has been proposed. A chronic state of insulin resistance is a rapidly increasing disease condition in Western and developing ...
Aerts, J.M. +15 more
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Insulin Receptors and Insulin Resistance
Annual Review of Medicine, 1983Resistance to the action of insulin plays a central role in many important disease states, including diabetes and obesity. Many insights into the mechanism and significance of insulin resistance in these and other disorders have followed upon our expanding knowledge regarding insulin receptors.
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Insulin, Cation Metabolism and Insulin Resistance
Journal of Basic and Clinical Physiology and Pharmacology, 1998There is considerable evidence that insulin and insulin-like growth factors regulate a number of important physiological functions in a variety of tissues, some not considered to be classically insulin sensitive. Impaired biological responses to insulin and related insulin-like growth factors are referred to as insulin resistance.
J R, Sowers, B, Draznin
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Insulin Receptor Autoimmunity and Insulin Resistance
Journal of Pediatric Endocrinology and Metabolism, 2008The frequency of insulin receptor autoantibodies (IR-ab) was determined among adolescents and young adults with documented insulin resistance syndrome (IRS) with and without concomitant autoimmunity. The study population was comprised of 61 patients with obesity, acanthosis nigricans and insulin resistance (simple IRS); 12 with IRS and other autoimmune
Ping, Zhou +5 more
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Insulin resistance and hypertension
Molecular and Cellular Endocrinology, 1990Diminished insulin (Ins) sensitivity is a characteristic feature of various pathological conditions such as the cardiometabolic syndrome, Type 2 diabetes, and hypertension. Persons with essential hypertension are more prone than normotensive persons to develop diabetes, and this propensity may reflect decreased ability of Ins to promote relaxation and
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Insulin Receptor Antibodies and Insulin Resistance
Southern Medical Journal, 1999The presence of insulin receptor antibodies is a rare cause of insulin resistance. Patients usually have a combination of hyperglycemia, insulin resistance, acanthosis nigricans, and autoimmune features. We report a patient with systemic lupus erythematosus and severe insulin resistance due to insulin receptor antibodies.
C H, Magsino, J, Spencer
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Endocrine, 2014
Obesity is a multifactorial disease that caused by the interactions between genetic susceptibility genes and environmental cues. Obesity is considered as a major risk factor of insulin resistance. STEAP4 is a novel anti-obesity gene that is significantly down-regulated in adipose tissue of obese patients.
Xiaoling, Chen +6 more
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Obesity is a multifactorial disease that caused by the interactions between genetic susceptibility genes and environmental cues. Obesity is considered as a major risk factor of insulin resistance. STEAP4 is a novel anti-obesity gene that is significantly down-regulated in adipose tissue of obese patients.
Xiaoling, Chen +6 more
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Journal of Diabetes and its Complications, 2016
Sirtuin 1 (SIRT1) is a prototype mammalian NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. Growing evidence suggests that SIRT1 regulates glucose and lipid metabolism through its deacetylase activity.
Yue, Cao +5 more
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Sirtuin 1 (SIRT1) is a prototype mammalian NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. Growing evidence suggests that SIRT1 regulates glucose and lipid metabolism through its deacetylase activity.
Yue, Cao +5 more
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Insulin Resistance and Insulin Resistance Syndrome
2013METABOLISM AND HYPERTENSION Insulin Resistance Syndrome and Glycogen Synthesis, Roles of Muscle, Liver and Adipose Tissue, Hagit Eldar-Finkelman and Merav Yarkoni Hypertension and Insulin Resistance in the SJHR-Koletsky Rats, Jianhua Shao and Jacob Friedman Role of PTPase in Insulin Action and Insuln Resistance Recent Insights from Cellular and Animal ...
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