Results 251 to 260 of about 948,845 (312)

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Association between insulin resistance trajectories and perinatal complications: a retrospective cohort study. [PDF]

Front Endocrinol (Lausanne)
Ye L, Shen L, Zhang S, Zhu C, Cai S, Huang J, Xie L, Chen H.   +7 more
europepmc   +1 more source

Insulin resistance in cerebral small vessel disease: a mini review. [PDF]

Front Neurosci
Su C, Cui Z, Guo J.
europepmc   +1 more source

Integrated analysis of insulin resistance reveals metabolic remodeling following diet switch-triggered calorie reduction. [PDF]

Sci Adv
Duan X, Davis LM, Patel S, Bidault G, Long L, Jenkins B, Yi Y, Pushpa P, Wesseling JR, Koulman A, Vidal-Puig A, Fazakerley DJ, Savage DB.   +12 more
europepmc   +1 more source