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Chronic insulin resistance

Acta Diabetologica Latina, 1970
Chronic insulin resistance has been defined and its clinical characteristics summarized. Although increased insulin antibodies can be demonstrated in most patients with chronic insulin resistance, there is not always a good correlation between the severity of the insulin resistance and the titer of insulin antibodies. Several insulin resistant patients
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Insulin, Cation Metabolism and Insulin Resistance

Journal of Basic and Clinical Physiology and Pharmacology, 1998
There is considerable evidence that insulin and insulin-like growth factors regulate a number of important physiological functions in a variety of tissues, some not considered to be classically insulin sensitive. Impaired biological responses to insulin and related insulin-like growth factors are referred to as insulin resistance.
J R, Sowers, B, Draznin
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Insulin Receptor Autoimmunity and Insulin Resistance

Journal of Pediatric Endocrinology and Metabolism, 2008
The frequency of insulin receptor autoantibodies (IR-ab) was determined among adolescents and young adults with documented insulin resistance syndrome (IRS) with and without concomitant autoimmunity. The study population was comprised of 61 patients with obesity, acanthosis nigricans and insulin resistance (simple IRS); 12 with IRS and other autoimmune
Ping, Zhou   +5 more
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Insulin Receptor Antibodies and Insulin Resistance

Southern Medical Journal, 1999
The presence of insulin receptor antibodies is a rare cause of insulin resistance. Patients usually have a combination of hyperglycemia, insulin resistance, acanthosis nigricans, and autoimmune features. We report a patient with systemic lupus erythematosus and severe insulin resistance due to insulin receptor antibodies.
C H, Magsino, J, Spencer
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Insulin, Insulin Resistance, Obesity, and Cancer

Current Diabetes Reports, 2010
Epidemiologic studies have proposed a link between obesity, type 2 diabetes, and cancer. The pathophysiologic mechanisms involved in the development of type 2 diabetes, namely hyperinsulinemia and insulin resistance, have also been implicated in cancer development.
Emily Jane, Gallagher, Derek, LeRoith
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Glycosphingolipids and Insulin Resistance

2011
Glycosphingolipids are structural membrane components, residing largely in the plasma membrane with their sugar-moieties exposed at the cell's surface. In recent times a crucial role for glycosphingolipids in insulin resistance has been proposed. A chronic state of insulin resistance is a rapidly increasing disease condition in Western and developing ...
Aerts, J.M.   +15 more
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Insulin resistance and hypertension

Molecular and Cellular Endocrinology, 1990
Diminished insulin (Ins) sensitivity is a characteristic feature of various pathological conditions such as the cardiometabolic syndrome, Type 2 diabetes, and hypertension. Persons with essential hypertension are more prone than normotensive persons to develop diabetes, and this propensity may reflect decreased ability of Ins to promote relaxation and
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Insulin Resistance and Insulin Resistance Syndrome

2013
METABOLISM AND HYPERTENSION Insulin Resistance Syndrome and Glycogen Synthesis, Roles of Muscle, Liver and Adipose Tissue, Hagit Eldar-Finkelman and Merav Yarkoni Hypertension and Insulin Resistance in the SJHR-Koletsky Rats, Jianhua Shao and Jacob Friedman Role of PTPase in Insulin Action and Insuln Resistance Recent Insights from Cellular and Animal ...
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Insulin Resistance

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1998
D C, Whitelaw, S G, Gilbey
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Insulin Resistant States and Insulin Signaling

Clinical Chemistry and Laboratory Medicine, 2003
The incidence of type 2 diabetes mellitus (T2D) and obesity is increasing rapidly worldwide, reaching epidemic proportions. Insulin resistance is a key feature in both conditions and plays an important pathophysiological role. Over the last two decades a central role in the origin of insulin resistance has emerged for defects in the intracellular ...
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