Results 261 to 270 of about 3,853,066 (390)

Hyperinsulinemia, Insulin Resistance, and Hypertension

, 1994
Gerd Bönner
openalex   +1 more source

Insulin resistance causes inflammation in adipose tissue

Journal of Clinical Investigation, 2018
Mitsugu Shimobayashi, Verena Albert, B. Woelnerhanssen, Irina C. Frei, Diana Weissenberger, A. C. Meyer-Gerspach, Nicolas Clement, S. Moes, M. Colombi, J. A. Meier, Marta M. Swierczynska, P. Jenö, C. Beglinger, R. Peterli, M. Hall   +14 more
semanticscholar   +1 more source

Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population

Advanced Science, EarlyView.
This study identifies the indispensable role of gut microbiota in the maintenance of ST2+ adipose Treg cell population, and defines gut microbiota‐derived butyrate as an endogenous PPARγ agonist, modulating adipose Treg cell populations via promoting PPARγ activation. Butyrate or fiber supplementation restores the VAT ST2+ Treg population in obese mice
Banru Chen, Lizhi Guan, Chao Wu, Yiwen Gong, Lei Wu, Minchun Zhang, Zhiwen Cao, Yufei Chen, Chengcan Yang, Bing Wang, Yunqi Li, Bin Li, Yufang Bi, Guang Ning, Jiqiu Wang, Weiqing Wang, Ruixin Liu   +16 more
wiley   +1 more source

Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy

Nature Reviews Endocrinology, 2016
Guanghong Jia, V. DeMarco, J. Sowers
semanticscholar   +1 more source

PLIN2 Promotes Lipid Accumulation in Ascites‐Associated Macrophages and Ovarian Cancer Progression by HIF1α/SPP1 Signaling

Advanced Science, Volume 12, Issue 12, March 27, 2025.
This study interrogated the single‐cell transcriptome of immune cells across multiple anatomical sites in ovarian cancer patients and identified a novel subset of macrophages that are enriched in ascites and overexpressed the lipid droplet protein PLIN2.
Hui Luo, Xiaolu She, Yubo Zhang, Bingfan Xie, Shibo Zhang, Qianqian Li, Yangyang Zhou, Shuang Guo, Shushan Zhang, Yanhui Jiang, Yingying Dong, Jianzhong He, Lijie Wang, Qianqian Zhang, Yuan Zhuang, Panxia Deng, Feng Wang, Jihong Liu, Xin Chen, Huilong Nie, Huanhuan He   +20 more
wiley   +1 more source

Local patterns of genetic sharing between neuropsychiatric and insulin resistance-related conditions. [PDF]

Transl Psychiatry
Fanelli G, Franke B, Fabbri C, Werme J, Erdogan I, De Witte W, Poelmans G, Ruisch IH, Reus LM, van Gils V, Jansen WJ, Vos SJB, Alam KA, Martinez A, Haavik J, Wimberley T, Dalsgaard S, Fóthi Á, Barta C, Fernandez-Aranda F, Jimenez-Murcia S, Berkel S, Matura S, Salas-Salvadó J, Arenella M, Serretti A, Mota NR, Bralten J.   +27 more
europepmc   +1 more source

Synthetic Lethality of SHP2 and XIAP Suppresses Proliferation and Metastasis in KRAS‐mutant Nonsmall Cell Lung Cancer

Advanced Science, Volume 12, Issue 15, April 17, 2025.
Embelin cotargets SHP2 to disrupt the SHP2/GRB2/SOS complex, inhibiting cancer‐related signaling pathways such as MAPK, (PI3K)/AKT pathway, and XIAP to induce apoptosis signaling pathway, respectively, leading to synthetic lethality in KRAS‐mutant NSCLC cells both in vivo and in vitro.
Nai‐jie Fu, Yu‐wen Sheng, Zhe Fan, Zhao Wu, Ling‐yu Li, Rui‐ying Xi, Xiao‐ke Shi, Guo‐lin Zhang, Fei Wang   +8 more
wiley   +1 more source

Advanced glycation end-product intake predicts insulin resistance in a sex-dependent fashion. [PDF]

Eur J Nutr
Sergi D, Angelini S, Spaggiari R, Castaldo F, Zuliani G, Sanz JM, Passaro A, PANGEA study group.   +7 more
europepmc   +1 more source

hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation

Advanced Science, EarlyView.
This article addresses the absence of zonation features in current organoid models by co‐culturing human embryonic stem cell‐derived hepatocytes with liver sinusoidal endothelial cells exhibiting distinct zonal characteristics. It demonstrates that differential WNT2 signaling from endothelial cells modulates hepatocyte zonation and metabolic functions,
Yuying Zhang, Chenyan Huang, Lei Sun, Lyu Zhou, Yudi Niu, Kaini Liang, Bingjie Wu, Peng Zhao, Zhiqiang Liu, Xiaolin Zhou, Peng Zhang, Jianchen Wu, Jie Na, Yanan Du   +13 more
wiley   +1 more source

The association between thyroid function and insulin resistance as measured by the metabolic score for insulin resistance (METS-IR): insights from NHANES 2007-2012. [PDF]

BMC Endocr Disord
Safari F, Nabavizadeh A, Vardanjani HM.
europepmc   +1 more source