Results 261 to 270 of about 4,469,131 (358)

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux.

Journal of Clinical Investigation, 2016
V. Samuel, G. Shulman
semanticscholar   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Evaluating indices of insulin resistance and estimating the prevalence of insulin resistance in a large biobank cohort. [PDF]

Front Endocrinol (Lausanne)
Aliyu U, Toor SM, Abdalhakam I, Elrayess MA, Abou Samra AB, Albagha OME.   +5 more
europepmc   +1 more source

Coordinated Defects in Hepatic Long Chain Fatty Acid Metabolism and Triglyceride Accumulation Contribute to Insulin Resistance in Non-Human Primates

, 2011
Subhash Kamath, Alberto O. Chávez, Amalia Gastaldelli, Francesca Casiraghi, Glenn A. Halff, Gregory Abrahamian, Alberto M. Davalli, Raúl A. Bastarrachea, Anthony G. Comuzzie, Rodolfo Guardado‐Mendoza, Lilia M. Jiménez-Ceja, Vicki Mattern, Ana Paez, Andrea Ricotti, M. Elizabeth Tejero, Paul B. Higgins, Iram P. Rodríguez‐Sánchez, Devjit Tripathy, Ralph A. DeFronzo, Edward J. Dick, Gary W. Cline, Franco Folli   +21 more
openalex   +2 more sources

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

Atherosclerosis and Insulin Resistance: Is There a Link Between Them? [PDF]

Biomedicines
Brie AD, Christodorescu RM, Popescu R, Adam O, Tîrziu A, Brie DM.   +5 more
europepmc   +1 more source

Skeletal muscle glucocorticoid receptor density and insulin resistance. [PDF]

, 2002
Chapman, Karen E, Lithell, Hans O, McKeigue, Paul M, Reynolds, Rebecca M, Seckl, Jonathan R, Walker, Brian R   +5 more
core   +1 more source

The role of endoplasmic reticulum stress in hippocampal insulin resistance

, 2016
Catrina Sims‐Robinson, Anna Bakeman, Rebecca Glasser, Janet M. Boggs, Crystal Pacut, Eva L. Feldman   +5 more
openalex   +1 more source

Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re‐esterification via Glycerol Kinase Upregulation

Advanced Science, EarlyView.
Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun, Miriayi Alimujiang, Wenfei Li, Shuqin Chen, Yingying Su, Tingting Hu, Xuhong Lu, Yafen Ye, Ningning Bai, Fan Hu, Xiaoya Li, Rongrong Xu, Jun Xu, Jiarui Zhao, Yan Lu, Xiaojing Ma, Ying Yang   +16 more
wiley   +1 more source

How much insulin resistance in polycystic ovary syndrome? Comparison of HOMA-IR and insulin resistance (Belfiore) index models

Archives of Medical Science, 2019
Krzysztof C. Lewandowski, Elżbieta Skowrońska-Jóźwiak, Katarzyna Łukasiak, Katarzyna Gałuszko, Aleksandra Dukowicz, Magdalena Cedro, Andrzej Lewiński   +6 more
doaj   +1 more source