Results 191 to 200 of about 307,626 (315)

Sidt2 inhibits islet β-cell dedifferentiation by regulating insulin secretion. [PDF]

J Biol Chem
Gu J, Qi MX, Zhang RX, Song YY, Hu X, Liu HJ, Zhang YT, Wu WX, Wu YJ, Xu JH, Wang JH, Li JR, Liu MM, Pei WJ, Zhang Y, Wang LZ, Gao JL.   +16 more
europepmc   +1 more source

Engineered Small Extracellular Vesicles Targeting Tumor‐Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment

Advanced Science, EarlyView.
This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.
Lingling Liu, Feiyang Xu, Zhiming Zheng, Xiaodan Yang, Fang Yang, Pei Liu, Yuankun Chen, Yunshu Yang, Junli Zhao, Peiyan Yang, Xiaojing Zheng, Xiaohong Sun, Ping Mao, Qinwen Mao, Hao Guan, Haibin Xia, Weifeng Zhang, Dan Xiao   +17 more
wiley   +1 more source

Beta cell secreted GABA sets appropriate insulin secretion by modulating islet calcium oscillations. [PDF]

Mol Metab
Ferreira SM, Hagan DW, Stis AE, Widener AE, Cuaycal AE, Rancourt C, Readey AG, Smurlick DS, Fu DA, Campbell-Thompson M, Rupnik MS, Phelps EA.   +11 more
europepmc   +1 more source

Roles of Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, and Release of Intracellular Ca2+ Stores in Insulin-stimulated Insulin Secretion in β-Cells [PDF]

, 2000
Craig A. Aspinwall, Weijun Qian, Michael G. Roper, Rohit Kulkarni, C. Ronald Kahn, Robert T. Kennedy   +5 more
openalex   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Assessing the rate dependence of the first phase of glucose-stimulated insulin secretion: dynamic perifusion studies with isolated human pancreatic islets. [PDF]

Am J Physiol Endocrinol Metab
Buchwald P, Chuang ST, Watts B, Alcazar O.   +3 more
europepmc   +1 more source

<p>Major miRNA Involved in Insulin Secretion and Production in Beta-Cells</p>

, 2020
Mohsen Aghaei, Ali Khodadadian, Elham Karimi‐Nazari, Majid Nazari, Emad Babakhanzadeh   +4 more
openalex   +2 more sources

Kinetic study of the processing by dipeptidyl‐peptidase IV/CD26 of neuropeptides involved in pancreatic insulin secretion [PDF]

, 2001
Anne‐Marie Lambeir, Christine Durinx, Paul Proost, Jo Van Damme, Simon Scharpé, Ingrid De Meester   +5 more
openalex   +1 more source

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

Perinatal and postpartum insulin secretion capacity in women with early-onset and late-onset gestational diabetes. [PDF]

BMJ Open Diabetes Res Care
Katayama A, Hasegawa M, Morimoto E, Watanabe M, Matsushita Y, Takeda M, Kai K, Yoshida M, Tsukahara S, Okimoto N, Tada K, Kumazawa K, Hida K.   +12 more
europepmc   +1 more source