Results 171 to 180 of about 8,323 (219)
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Insulin secretion in hyperlipoproteinemias
Acta Diabetologica Latina, 1974Insulin secretion has been evaluated after oral glucose loading and other stimuli (tolbutamide, glucagon, arginine and i.v. glucose) in a group of 3 patients with familial hyperchylomicronemia (Fredrickson’s Type I), 33 patients with primary hypercholesterolemia (Fredrickson’s Type II) and 89 patients with endogenous hypertriglyceridemia.
A. Tiengo +4 more
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New England Journal of Medicine, 1967
ALTHOUGH hyperinsulinemia has been well established in obese subjects1 , 2 only some demonstrate abnormalities of glucose tolerance. It has been suggested that the ability of the obese subject to maintain normal glucose tolerance is a function of B-cell reserve, implying that insulin secretory rates and plasma insulin levels would be higher in obese ...
R A, Kreisberg +3 more
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ALTHOUGH hyperinsulinemia has been well established in obese subjects1 , 2 only some demonstrate abnormalities of glucose tolerance. It has been suggested that the ability of the obese subject to maintain normal glucose tolerance is a function of B-cell reserve, implying that insulin secretory rates and plasma insulin levels would be higher in obese ...
R A, Kreisberg +3 more
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Mechanisms of Insulin Secretion
New England Journal of Medicine, 1970IN the bodily economy of animals, including man, insulin has evolved into the premier regulator of storage and conservation of the three major foodstuffs.
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Insulin Secretion in Acromegaly
The Journal of Clinical Endocrinology & Metabolism, 1970ABSTRACT A comparative study of insulin release was made in 9 acromegalic and 39 normal subjects who had normal fasting plasma glucoses. Both hyperglycemic (increase of plasma glucose of at least 25 mg/100 ml) and nonhyperglycemic stimuli were used. Those producing hyperglycemia included a 100 g oral glucose tolerance test and a glucose-protein meal ...
S E, Fineberg +3 more
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Metabolism, 1984
Recent advances in insulin secretion indicate that pertussis toxin abolishes the inhibition by alpha 2 adrenoceptor activation of insulin release by the pancreas. Pertussis toxin adenosine diphosphate (ADP) ribosylates an inhibitory guanine nucleotide-binding protein (Ni) involved in inhibition of adenylate cyclase.
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Recent advances in insulin secretion indicate that pertussis toxin abolishes the inhibition by alpha 2 adrenoceptor activation of insulin release by the pancreas. Pertussis toxin adenosine diphosphate (ADP) ribosylates an inhibitory guanine nucleotide-binding protein (Ni) involved in inhibition of adenylate cyclase.
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Biosynthesis and secretion of insulin
British Medical Bulletin, 1989The mechanisms involved in the biosynthesis, storage and secretion of insulin in the normal pancreatic B-cell have been the subject of intensive investigation during the last twenty years. As a result of this activity a relatively clear picture has emerged about the basic processes involved, and increasing information is available of their regulation ...
S L, Howell, G S, Bird
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Hypothermia and Insulin Secretion
Endocrinology, 1970The effect of decreased body temperature on insulin secretion was studied using the isolated perfused rat pancreas. It was found that hypothermia directly inhibits insulin release and that there exists a direct relationship between tissue temperature and total quantity of insulin released (in response to either glucose or tolbutamide stimulation).
D L, Curry, K P, Curry
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Inhibition of Insulin Secretion
2005Reports of the effects of amylin and amylin agonists on insulin secretion have varied widely. Some confusion can be attributed to the use of human amylin, which has been shown to readily fall out of solution resulting in low estimates of bioactivity. Some confusion can be resolved by assessing the probability that this had happened. The view taken here,
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Multiscale Modeling of Insulin Secretion
IEEE Transactions on Biomedical Engineering, 2011Insulin secretion from pancreatic beta cells is a fundamental physiological process, and its impairment plays a pivotal role in the development of diabetes. Mathematical modeling of insulin secretion has a long history, both on the level of the entire body and on the cellular and subcellular scale.
PEDERSEN, MORTEN GRAM +2 more
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Effects of Aging on Insulin Secretion
Diabetes, 1989Aging is associated with hyperinsulinemia, but reports vary on the contributions of altered insulin clearance versus insulin secretion to this phenomenon. To elucidate the role of insulin secretion in the hyperinsulinemia of aging, 10 elderly (age 66 ± 4 yr, body mass index 25 ± kg/m2) and 8 young (age 30 ± 5 yr, body mass index 24 ± 3 kg/m2) subjects ...
B, Gumbiner +5 more
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