Results 161 to 170 of about 8,323 (219)

GLP‐1 Receptor Agonists and Endoscopy: Understanding Gastric Stasis, Aspiration Risk, and Contemporary Peri‐Procedural Guidance

Chronic Diseases and Translational Medicine, EarlyView.
Pharmacological mechanisms and physiologic effects of GLP‐1 receptor agonists relevant to peri‐endoscopic risk. ABSTRACT The global increase in obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD) has led to a higher use of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) among patients ...
Junaid Beig, Jason Ta, Sophie Jones, Emily Scott, Khalid Sofi, Frances Osler, Marije Jansen, Puneet Chhabra   +7 more
wiley   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Disentangling Sex Differences in Sulfonylurea Drug Response With Genome‐Wide Association Studies in Individuals With Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
A sex‐stratified genome‐wide association study of sulfonylurea response identified sex‐specific genetic loci associated with HbA1c reduction in individuals with type 2 diabetes. Replication and functional validation supported a male‐specific association at the TMEM64/NECAB1 locus, highlighting the potential of sex‐informed pharmacogenomics to advance ...
Joseph H. Breeyear, John S. House, Mark Kvale, Stella Nam, Farida S. Akhtari, Hetal S. Shah, Monique M. Hedderson, Kathleen M. Giacomini, Josyf C. Mychaleckyj, Alessandro Doria, Michael J. Wagner, Josephine H. Li, Sook Wah Yee, John B. Buse, Richard P. Woychik, Daniel M. Rotroff, Alison A. Motsinger‐Reif   +16 more
wiley   +1 more source

Taking Into Account Insulin Resistance With Associated Hyperinsulinemia to Counteract the Development of Acute and Chronic Cardiovascular Diseases

Chronic Diseases and Translational Medicine, EarlyView.
Serafino Fazio, Flora Affuso
wiley   +1 more source

[Insulin secretion in non-insulin-dependent diabetes].

Journees annuelles de diabetologie de l'Hotel-Dieu, 1991
Turner, R, Clark, A, Levy, J, Hattersley, A, Cook, J   +4 more
openaire   +3 more sources

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Deoxysugars and Insulin Secretion

Hormone and Metabolic Research, 1977
It has been shown that a deoxysugar, D(+)-digitoxose, inhibits glucose-induced insulin release without inhibiting the glucose oxidation rates of the islets. In the present study the effect on insulin release of several other common deoxysugar (L-fucose, D-fucose, L-rhamnose, 2-deoxy-D-galactose and 2-deoxy-D-ribose) was investigated. We have found that
García-Hermida, Ofelia, Gómez-Acebo, J.   +1 more
openaire   +3 more sources

Insulin Secretion in Kwashiorkor

The Journal of Clinical Endocrinology & Metabolism, 1972
ABSTRACT Basal plasma insulin levels were normal in kwashiorkor, but their response to oral glucose was impaired. As a result of the impaired insulin secretion, the glucose tolerance was abnormal and there was no reduction in plasma α-amino nitrogen levels.
K S, Jaya Rao, N, Raghuramulu
openaire   +2 more sources

Somatostatin and insulin secretion

Metabolism, 1978
Abstract The inhibitory effect of somatostatin was first demonstrated in in vitro studies in rat pituitary cell cultures. Thus, initially, its action on the release of pituitary hormones in man and animals was the main focus of interest. While investigating the effect of somatostatin on growth hormone release we, as well as other groups, made the ...
S, Efendic, P E, Lins, R, Luft
openaire   +2 more sources

Aging and insulin secretion

American Journal of Physiology-Endocrinology and Metabolism, 2003
Glucose tolerance progressively declines with age, and there is a high prevalence of type 2 diabetes and postchallenge hyperglycemia in the older population. Age-related glucose intolerance in humans is often accompanied by insulin resistance, but circulating insulin levels are similar to those of younger people. Under some conditions of hyperglycemic
Annette M, Chang, Jeffrey B, Halter
openaire   +2 more sources

The cytoskeleton and insulin secretion

Diabetes/Metabolism Reviews, 1986
One of the central, unresolved problems in our understanding of insulin secretion is the way in which stimulus recognition and its associated metabolic events are translated into the mechanical processes of insulin-storage granule movement and extrusion from the cells by exocytosis. In the present article we have examined the structural organization of
S L, Howell, M, Tyhurst
openaire   +2 more sources