Results 181 to 190 of about 543,808 (360)

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Dehydroepiandrosterone increases β‐cell mass and improves the glucose‐induced insulin secretion by pancreatic islets from aged rats [PDF]

, 2005
Mayrin Correa Medina, L C. Souza, Luciana C. Caperuto, Gabriel Forato Anhê, Angélica M. Amanso, Vicente P. A. Teixeira, Silvana Bordin, Ângelo Rafael Carpinelli, Luiz Roberto Britto, Renato L. Barbieri, Maria Inês Borella, Carla Roberta de Oliveira Carvalho   +11 more
openalex   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Tomosyn-2 Regulates Postnatal β-Cell Expansion and Insulin Secretion to Maintain Glucose Homeostasis. [PDF]

Diabetes
Perez KC, Alexander J, Rahman MM, Alsharif H, Liu Y, Kim JA, Hunter CS, Nguyen T, Bhatnagar S.   +8 more
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

How Astragalin Modulates Glucose Uptake and Insulin Secretion in β-Cell Lines. [PDF]

Pharmaceuticals (Basel)
Sulis PM, Mendes ALR, Bunick PWZ, Cesca K, Royer C, Zaniboni BA, Cavalari FC, Pintarelli GB, Dagostin ALA, Silva FRMB.   +9 more
europepmc   +1 more source

Human Islet MicroRNA-200c is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion

, 2021
Jones K. Ofori, Alexandros Karagiannopoulos, Mototsugu Nagao, Efraim Westholm, Shaima Ramadan, Anna Wendt, Jonathan LS Esguerra, Lena Eliasson   +7 more
openalex   +2 more sources

The role of Ca2+ as a trigger for the membrane fusion [PDF]

, 1980
Abrahamsson, Hasse, Dahl, G., Ekerdt, R., Gratzl, Manfred, Malaisse, Willy J.   +4 more
core   +1 more source

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Glucose control of basal insulin secretion in diabetes [PDF]

, 1977
Sharon McCarthy, E. Harris, R. C. Turner
openalex   +1 more source