Results 191 to 200 of about 543,808 (360)

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science, EarlyView.
The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
wiley   +1 more source

Gαs defines the fundamental coupling mechanism of insulin secretion. [PDF]

J Diabetes Investig
Shirakawa J.
europepmc   +1 more source

Loss of a priming effect of glucose on A and D cell secretion in perfused pancreases from alloxan-diabetic rats: Role of insulin and alloxan [PDF]

, 1983
Valdemar Grill, Suad Efendić
openalex   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Dual action of imeglimin on insulin secretion and sensitivity in type 2 diabetes. [PDF]

Diabetes Obes Metab
Tajima T, Kaga H, Ito N, Kogai T, Naito H, Kakehi S, Kadowaki S, Nishida Y, Kawamori R, Tamura Y, Watada H.   +10 more
europepmc   +1 more source

Variations in Insulin Secretion in Carriers of Gene Variants in IRS-1 and -2 [PDF]

, 2002
Leen M. ‘t Hart, Giel Nijpels, Joost Dekker, J. A. Maassen, Robert J. Heine, Timon W. van Haeften   +5 more
openalex   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

NERP-4-Deleted VGF Impairs β-Cell Granulogenesis and Insulin Secretion. [PDF]

FASEB J
Zhang W, Nakazato Y, Minamino N, Okumura N, Miura A, Tarusawa T, Mizukami H, Sakoda H, Nakazato M.   +8 more
europepmc   +1 more source

Chromium and insulin secretion [PDF]

Diabetologia, 1980
openaire   +2 more sources

The autoregulation of insulin secretion in the isolated pancreatic islets of lean (obOb) and obese-hyperglycemic (obob) mice [PDF]

, 1974
L. Loreti, Joseph C. Dunbar, S. Chen, P. P. Foà   +3 more
openalex   +1 more source