Results 191 to 200 of about 989,753 (307)

Association of Ultra-Processed Food Intake with Insulin Secretion and Sensitivity in Mexican American Children: Results from the SAFARI Study. [PDF]

Nutrients
Kulkarni H, Arya R, Mummidi S, Fowler SP, Resendez RG, Lopez-Alvarenga JC, Diaz-Badillo A, Schneider J, Puppala S, Farook V, Hale DE, Lynch JL, Johnston BC, Golla V, Lehman DM, DeFronzo RA, Blangero J, Duggirala R.   +17 more
europepmc   +1 more source

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

Advanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao, Guifang Pan, Jincai Zhang, Yue Gong, Wenjian Zhang, Huiling Shen, Xingxing Li, Yuehan Ouyang, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

β-Cell Dysfunction in COVID-19 and Post-COVID Syndrome: Molecular Mechanisms Linking Inflammation, Oxidative Stress, and Insulin Secretion. [PDF]

Int J Mol Sci
Tsvetkova V, Todorova K.
europepmc   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

A distinct vagus-beta cell neural circuit senses glucose and modulates insulin secretion. [PDF]

Mol Metab
Kumar S, Bahn YJ, Gao C, Lee JH, Noguchi A, Baena V, Syed ZA, Auh S, Lutas A, Krashes MJ, Rane SG.   +10 more
europepmc   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Free fatty acid receptor 4 agonism stimulates insulin secretion via different mechanisms in mouse versus human islets.

Endocrinology
Reininger L, Rehman M, Hart R, Ferragne S, Tremblay C, Ethier M, Bouabcha A, Kimple M, Ghislain J, Huising MO, Poitout V.   +10 more
europepmc   +1 more source

Melatonin Impairs Glucose Tolerance, First-Phase Insulin Secretion, and Insulin Feedback Inhibition; Interaction With MTNR1B Diabetes Risk Variant. [PDF]

Diabetes Care
Qian J, Stefanovski D, Andersen PAK, Vujovic N, Kelly L, Lepson J, Nguyen H, Byrne S, Wang W, Mandrup-Poulsen T, Adler G, Garaulet M, Saxena R, Scheer FAJL.   +13 more
europepmc   +1 more source

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

Tomosyn-2 Regulates Postnatal β-Cell Expansion and Insulin Secretion to Maintain Glucose Homeostasis. [PDF]

Diabetes
Perez KC, Alexander J, Rahman MM, Alsharif H, Liu Y, Kim JA, Hunter CS, Nguyen T, Bhatnagar S.   +8 more
europepmc   +1 more source