Results 231 to 240 of about 307,626 (315)

LRRK2 kinase modulates glucose-stimulated insulin secretion via RAB8 phosphorylation and ciliogenesis. [PDF]

Cell Mol Life Sci
Dule N, Marku A, Galli A, Pischedda F, Lama A, Castagna M, Marciani P, Bertuzzi F, Piccoli G, Perego C.   +9 more
europepmc   +1 more source

Real‐Time and High‐Resolution NIR‐II‐L Imaging of Netrin‐1‐Mediated Neurovascular Coupling Driven by Dose‐Dependent Electroacupuncture

Advanced Science, EarlyView.
Disrupted neurovascular coupling contributes to ovarian dysfunction in polycystic ovary syndrome. Using near‑infrared II long‑wavelength imaging, this study visualizes how electroacupuncture dynamically regulates ovarian blood vessels in vivo. Immediate and cumulative stimulation elicit distinct vascular responses via a Netrin‐1 dependent mechanism ...
Yicong Wang, Zi‐Han Chen, Jiajia Li, Wei Hu, Ying Cao, Yu Wang, Xiaoyu Tong, Wenhan Lu, Yuze Yang, Yuehao Wang, Yan Xiao, Wenhao Gao, Yuning Chen, Yuyan Hou, Fan Zhang, Yi Feng   +15 more
wiley   +1 more source

β Cell Gαs signaling is critical for physiological and pharmacological enhancement of insulin secretion. [PDF]

J Clin Invest
Capozzi ME, Bouslov D, Sargsyan A, Chan MY, Chen A, Gray SM, Viloria K, Bareja A, Douros JD, Lewandowski SL, Tong JC, Hasib A, Cuozzo F, Ross EC, Foster MW, Weinstein LS, Hussain MA, Merrins MJ, Willard FS, Huising MO, Sloop KW, Hodson DJ, D'Alessio DA, Campbell JE.   +23 more
europepmc   +1 more source

Mapping CSC‐Mediated Ovarian Cancer Chemoresistance via CXCR4‐PET to Guide Precision Cisplatin Re‐Sensitization Therapy

Advanced Science, EarlyView.
CXCR4 functions as a potential cancer stem cell‐associated marker linked to chemoresistance in ovarian cancer, and an inhibitor of CXCR4, AMD3100, can enhance the cytotoxic response to cisplatin. Based on these findings, [68Ga]Ga‐Pentixafor positron emission tomography enables selective visualization of CXCR4‐high ovarian cancer, while AMD3100 combined
Lixia Feng, Simei Zhao, Zheng Wei, Wenwen Wang, Feiquan Ying, Lin Huang, Mengna Zhu, Mengqing Chen, Qiang Yang, Si Sun, Dawei Jiang, Lingling Gao, Jing Cai   +12 more
wiley   +1 more source

A Case of Fulminant Type 1 Diabetes With Residual Insulin Secretion. [PDF]

Cureus
Kato T, Harada N, Nishikawa Y, Yamamoto K, Murakami T, Ueda Y, Okamoto M, Yabe D.   +7 more
europepmc   +1 more source

Co‐Treatment With rhBMP‐2 and Rapamycin Modulates Osteogenesis–Adipogenesis Balance to Enhance Aged Bone Regeneration

Advanced Science, EarlyView.
This study demonstrates that the imbalance between osteogenic and adipogenic differentiation in senescent BMSCs, leading to excessive adipocyte accumulation, which subsequently impairs bone regeneration in aged mice. To address this pathological dysregulation, a novel energy‐supplying hydrogel system (PBR) has been developed to restore balanced ...
Zirui He, Xiaoqiao Bai, Fangru Xie, Xuan Wang, Fan Zhang, Yuanman Yu, Yuan Yuan, Changsheng Liu   +7 more
wiley   +1 more source

Subcellular Compartmentalization of Glucose Mediated Insulin Secretion. [PDF]

Cells
Wang Z, Gurlo T, Satin LS, Fraser SE, Butler PC.   +4 more
europepmc   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female Mice. [PDF]

Diabetes
Basu L, Grieco-St-Pierre L, Ching MEA, Stead JDH, Hanson AA, Palaniyandi J, van Zyl E, Hoyeck MP, McKay KS, van Allen KA, Lee H, Dai XQ, Bautista A, Fadzeyeva E, Mulvihill EE, Yauk CL, Mennigen JA, MacDonald PE, Bruin JE.   +18 more
europepmc   +1 more source

A Universal Metal–Flavonoid Coating Strategy: Engineering Biomaterials for Diabetic Bone Regeneration

Advanced Science, EarlyView.
Construction of metal–flavonoid functionalized coatings on conventional bone repair materials. A one‐pot method is used to directly construct multifunctional metal–flavonoid coatings on the surface of traditional bone repair materials by selecting metal ions with osteogenic/angiogenic properties and flavonoids with reactive oxygen species scavenging ...
Chen Yang, Chenle Dong, Lefeng Su, Zhiqiang Liu, Lingyi Hu, Qishu Jin, Hao Chen, Chunlong Zhang, Yihao Wu, Jiang Chang, Zhaowenbin Zhang, Jiandong Yuan   +11 more
wiley   +1 more source