Results 231 to 240 of about 523,944 (309)

SPARC-modified mesenchymal stem cells promote recovery of β-cells and insulin secretion by calcium ion homeostasis. [PDF]

Stem Cell Res Ther
Gao J, Li B, Tian H, Li C, Merzlikin N, Han D, Ling Z, Zhang Z, Zhu W, Dai J, Gerunova L, Lv C, Li N, Hua J.   +13 more
europepmc   +1 more source

Functional Advantage of Central Pancreatectomy Over Distal Pancreatectomy for Benign or Low‐Grade Malignant Tumors: A Comparative Analysis Based on 75‐g Oral Glucose Tolerance Test

Annals of Gastroenterological Surgery, EarlyView.
Central pancreatectomy (CP) better preserves postoperative pancreatic endocrine function than distal pancreatectomy for benign or low‐grade malignant tumors. The 75‐g oral glucose tolerance test demonstrated that CP maintained insulin secretion and glucose tolerance, highlighting its clinical advantage as a function‐preserving procedure.
Dongha Lee, Keiko Kamei, Chihoko Nobori, Yuta Yoshida, Takaaki Murase, Atsushi Takebe, Yuki Okuda, Naru Babaya, Yoshihisa Hiromine, Ippei Matsumoto   +9 more
wiley   +1 more source

Estimating homeostasis model assessment for insulin secretion by using multiple adaptive regression spline in healthy Taiwanese men. [PDF]

Sci Rep
Ma CH, Yeh PT, Yang CC, Pei D, Chu TW, Liang YJ.   +5 more
europepmc   +1 more source

First Korean Case of 5q35.2q35.3 Microduplication With Reversed Sotos Syndrome Phenotype and Growth Hormone Deficiency: Expanding the Endocrine Spectrum

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Sotos syndrome is an overgrowth disorder caused by nuclear receptor binding SET domain protein 1 (NSD1) haploinsufficiency, whereas reciprocal 5q35.2q35.3 microduplication produces a reversed phenotype with growth retardation, microcephaly, delayed bone age, and neurodevelopmental delay.
Sejin Kim, Jung Sook Ha, Jun Chul Byun
wiley   +1 more source

Novel Roles for Geranylgeranyl Transferase-III (GGTase-III) in Insulin Secretion. [PDF]

Cell Physiol Biochem
Gleason NF, Hali M, Kowluru A.
europepmc   +1 more source

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

In situ metabolomics reveals intra-islet metabolite changes upon in vivo stimulation of insulin secretion. [PDF]

J Biol Chem
Zhou Y, Baez N, Fu T, Brun T, Maechler P.   +4 more
europepmc   +1 more source

The role of membrane excitability in pancreatic β-cell glucotoxicity [PDF]

, 2019
Nichols, Colin G., Remedi, Maria S., Shyr, Zeenat A., Wang, Zhiyu, York, Nathaniel W.   +4 more
core   +1 more source

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target

Animal Models and Experimental Medicine, EarlyView.
We developed an animal model of early diabetic retinopathy (DR) in the tree shrew by feeding a high‐fat and high‐sugar diet in combination with STZ. Physiological and biochemical index detection, hematoxylin and eosin staining, and transmission electron microscopy were performed to examine DR.
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
wiley   +1 more source

Cyclic-imide derivative (5e) attenuates hyperglycemia in type 1 diabetic rats by protecting pancreatic cells and enhancing insulin secretion. [PDF]

Saudi Pharm J
Alanazi WA, Alenezi AH, El-Nagar DM, Alanazi MM, Almutairi MM, Abdel-Aziz AA, El-Azab AS.   +6 more
europepmc   +1 more source