Mechanism of Insulin Secretion Induced by Nutrient Abnormalities in Diabetes Mellitus.
, 2000 Yutaka Seino
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Bidirectional Insulin Granule Turnover in the Submembrane Space During K+ Depolarization‐Induced Secretion [PDF]
, 2011 Kathrin Hatlapatka +4 more
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Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice
Advanced Science, EarlyView.ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao +14 more
wiley +1 more source
Dynamic GLUT trafficking at high glucose levels enhances insulin secretion: Dysregulation leads to decreased insulin secretion during type 2 diabetes. [PDF]
Proc Natl Acad Sci U S APallavi A +4 more
europepmc +1 more source
Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
Advanced Science, EarlyView.The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel +15 more
wiley +1 more source
Causal role of genetically predicted impairment of branched-chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes. [PDF]
Diabetes Obes MetabZhou X, Lu J, Wang Z, Cheng KK, Li GH.
europepmc +1 more source
Starch synthase IIIa and starch branching enzyme IIb-deficient mutant rice line ameliorates pancreatic insulin secretion in rats: screening and evaluating mutant rice lines with antidiabetic functionalities [PDF]
, 2018 Yasutake Tanaka +9 more
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Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids
Advanced Science, EarlyView.Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan +19 more
wiley +1 more source
ERp46 mitigates lipotoxic ER stress to preserve GLUT2 expression and insulin secretion in β-cells. [PDF]
Biomed RepChen D, Chen X, Tian Y, Wang K, Han C.
europepmc +1 more source
Advanced Science, EarlyView.NSUN5 is downregulated in hyperuricaemic nephropathy. Overexpression of NSUN5 enhances the stability of SCD1 mRNA through the m5C reader YBX2, ultimately inhibiting ferroptosis in renal tubular epithelial cells. Additionally, this axis suppresses the NF‐κB signaling pathway to alleviate inflammation and upregulates ABCG2 to promote uric acid excretion,
Xiu‐xiu Song +12 more
wiley +1 more source