Animal‐Free Setup of a 3D Mature Adipocyte‐Macrophage Co‐Culture to Induce Inflammation In Vitro
Advanced Healthcare Materials, EarlyView.A completely animal‐free 3D co‐culture is developed using human fat cells and immune cells. Animal‐based materials are replaced with gellan gum hydrogel and a serum‐free medium. Immune cells are effectively activated, producing specific inflammatory signals.
Sophia Nowakowski +3 more
wiley +1 more source
Multifunctional Biomedical Devices with Closed‐Loop Systems for Precision Therapy
Advanced Healthcare Materials, EarlyView.This review explores two major types of closed‐loop therapeutic systems: self‐sustained and externally triggered. It highlights recent advances in stimuli‐responsive materials, integrated bioelectronics, and data‐driven control strategies, offering insight into emerging strategies for personalized, responsive drug delivery.
Yixuan Leng, Rujie Sun
wiley +1 more source
THE PHYSIOLOGIC SIGNIFICANCE OF THE SECRETION OF ENDOGENOUS INSULIN INTO THE PORTAL CIRCULATION. I. COMPARISON OF THE EFFECTS OF GLUCAGON-FREE INSULIN ADMINISTERED VIA THE PORTAL VEIN AND VIA A PERIPHERAL VEIN ON THE MAGNITUDE OF HYPOGLYCEMIA AND PERIPHERAL GLUCOSE UTILIZATION1 [PDF]
, 1958 Leonard L. Madison, Roger H. Unger
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Advanced Healthcare Materials, EarlyView.An ex vivo glomerular filtration barrier is engineered using electrospun, biomimetic membranes seeded with human glomerular cells. The model supports fenestrated endothelium and podocyte foot processes under flow, mimics size‐selective filtration, and enables disease modeling with hiPSC‐derived podocytes, offering a powerful platform for studying ...
Camilla Mussoni +8 more
wiley +1 more source
CARBOHYDRATE TOLERANCE AFTER PROTAMINE INSULIN: ITS BEARING ON THE PHYSIOLOGY OF INSULIN SECRETION 1 [PDF]
, 1938 Henry T. Ricketts
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Advanced Healthcare Materials, EarlyView.A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi +10 more
wiley +1 more source
Journal of Pharmacological Sciences, 2008 Glucagon-like peptide-1 (GLP-1) induces pancreatic insulin secretion via the cAMP-dependent protein kinase (PKA) pathway. However, the GLP-1 concentration used in the previous in vitro experiments was far from the in vivo concentrations.
Makoto Shigeto +4 more
doaj
Advanced Healthcare Materials, EarlyView.Granular hydrogels are emerging microporous platforms for cell culture and delivery, showing great potential for replicating the complex, heterogeneous environments found in natural tissues. This review outlines the design principles of granular hydrogels, highlighting critical factors that determine the final physicochemical properties of the entire ...
Shuhan Feng, Kaiyang Chen, Shiqi Wang
wiley +1 more source
Insulin Secretion in Response to Glycemic Stimulus: Relation of Delayed Initial Release to Carbohydrate intolerance in Mild Diabetes Mellitus* [PDF]
, 1967 Holbrooke S. Seltzer +3 more
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3D Bioprinted Renal Constructs Using Kidney‐Specific ECM Bioink System on Kidney Regeneration
Advanced Healthcare Materials, EarlyView.A kidney‐specific bioink derived from decellularized porcine kidney tissue supports the encapsulation, viability, and maturation of human primary kidney cells within 3D bioprinted constructs. In vivo, it also promotes the recruitment of host renal progenitor cells, collectively enhancing structural and functional regeneration of renal tissue.
Gabriel Carreno‐Galeano +4 more
wiley +1 more source