Results 11 to 20 of about 427,560 (316)

Effect of the dietary fat quality on insulin sensitivity. [PDF]

, 2008
Recent evidence shows that specific fatty acids affect cell metabolism, modifying the balance between fatty acid oxidation and lipogenesis. These effects may have important implications in addressing the present epidemic of nutrition-related chronic ...
Aguirre, Carolina A, Uauy Dagach-Imbarack, Ricardo, Galgani Fuentes, José, Díaz Bustos, Erik, Aguirre, Carolina A., Galgani, José E, Uauy, Ricardo D, Díaz, Erik O   +7 more
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Fat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance? [PDF]

, 2010
<p><b>Background:</b> South Asians are more insulin resistant than Europeans, which cannot be fully explained by differences in adiposity. We investigated whether differences in oxidative capacity and capacity for fatty acid utilisation
Nita G Forouhi, Jason M R Gill, Hall, L.M.L., Hariharan, Narayanan, Salt, I.P., Hall, Lesley M L, Wilson, John, Niall G. MacFarlane, Niall G MacFarlane, Sattar, N., Milne, Gillian R, Gillian R Milne, MacFarlane, N.G., Gill, Jason M R, Gill Jason M. R., Lesley M. L. Hall, Moran Colin N., John Wilson, Sattar Naveed, Jason M. R. Gill, Colin N Moran, Gillian R. Milne, MacFarlane Niall G., Lesley M L Hall, Forouhi, N.G., MacFarlane, Niall G, Hariharan, N., Ian P Salt, Colin N. Moran, Hariharan Narayanan, Milne, G.R., Sattar, Naveed, Gill, J.M.R., Moran, C.N., Milne Gillian R., Nita G. Forouhi, Forouhi Nita G., Salt Ian P., Naveed Sattar, Narayanan Hariharan, Moran, Colin Neil, Hall Lesley M. L., Forouhi, Nita G, Salt, Ian P, Ian P. Salt, Wilson John   +45 more
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Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)

Metabolites, 2021
Insulin resistance and insufficient insulin secretion are well-recognized contributors to type 2 diabetes. A potential role of reduced insulin clearance has been suggested, but few studies have investigated the contribution of insulin clearance while ...
Alexis C. Wood, Elizabeth T. Jensen, Alain G. Bertoni, Gautam Ramesh, Stephen S. Rich, Jerome I. Rotter, Yii-Der I. Chen, Mark O. Goodarzi   +7 more
doaj   +1 more source

Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans [PDF]

, 2010
Objective: To study the association of vaspin with glucose metabolism. Design: Cross-sectional and intervention study. Subjects and methods: The association of serum vaspin with metabolic and anthropometric characteristics was investigated in 108
Isken, Frank, Randeva, Harpal S., Spranger, Joachim, Weickert, Martin O., Pfeiffer, Andreas F. H., Loeffelholz, Christian von, Möhlig, Matthias, Mai, Knut, Arafat, Ayman, M.   +8 more
core   +1 more source

Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A [PDF]

, 2014
Aims/HypothesisReduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated fatty acids (MUFA and PUFA) not only improve insulin sensitivity but blunt ...
Hage Hassan, Rima, Hundal, Harinder S, Gray, Alexander; id_orcid, Lipina Christopher, Hundal, Harinder S., Alexander Gray, Hajduch, Eric, Rima Hage Hassan, David Magill, Eric Hajduch, Hage Hassan Rima, Nardi, Francesca, Francesca Nardi, Hajduch Eric, Magill David, Gray, Alexander, Hundal Harinder S., Lipina, Christopher, Nardi Francesca, Harinder S Hundal, Magill, David, Christopher Lipina, Gray Alexander   +22 more
core   +1 more source

Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity

Cell Reports, 2018
Summary: Autophagy, a stress-induced lysosomal degradative pathway, has been assumed to exert similar metabolic effects in different organs. Here, we establish a model where autophagy plays different roles in insulin-producing β cells versus insulin ...
Soh Yamamoto, Kenta Kuramoto, Nan Wang, Xiaolei Situ, Medha Priyadarshini, Weiran Zhang, Jose Cordoba-Chacon, Brian T. Layden, Congcong He   +8 more
doaj   +1 more source

ZFYVE28 mediates insulin resistance by promoting phosphorylated insulin receptor degradation via increasing late endosomes production

Nature Communications, 2023
Insulin resistance is associated with many pathological conditions, and an in-depth understanding of the mechanisms involved is necessary to improve insulin sensitivity.
Liang Yu, Mengchen Xu, Yupeng Yan, Shuchen Huang, Mengmeng Yuan, Bing Cui, Cheng Lv, Yu Zhang, Hongrui Wang, Xiaolei Jin, Rutai Hui, Yibo Wang   +11 more
doaj   +1 more source

Changes in dominant groups of the gut microbiota do not explain cereal-fiber induced improvement of whole-body insulin sensitivity [PDF]

, 2011
Background Diets high in cereal-fiber (HCF) have been shown to improve whole-body insulin sensitivity. In search for potential mechanisms we hypothesized that a supplemented HCF-diet influences the composition of the human gut microbiota and/or ...
Pfeiffer, Andreas F. H., Arafat Ayman M, Leupelt Verena, Natalia Rudovich, Pfeiffer Andreas FH, Becker, Natalie, Verena Leupelt, Rudovich Natalia, Möhlig Matthias, Andreas FH Pfeiffer, Leupelt, Verena, Carl Alpert, Blaut Michael, Martin O Weickert, Arafat, Ayman M., Becker Natalie, Michael Blaut, Weickert Martin O, Weickert, Martin O., Möhlig, Matthias, Alpert, Carl, Rudovich, Natalia, Matthias Möhlig, Blaut, Michael, Natalie Becker, Alpert Carl, Ayman M Arafat   +26 more
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Acute glucagon induces postprandial peripheral insulin resistance. [PDF]

PLoS ONE, 2015
Glucagon levels are often moderately elevated in diabetes. It is known that glucagon leads to a decrease in hepatic glutathione (GSH) synthesis that in turn is associated with decreased postprandial insulin sensitivity.
Rita S Patarrão, W Wayne Lautt, M Paula Macedo   +2 more
doaj   +1 more source

Excessive daytime napping independently associated with decreased insulin sensitivity in cross-sectional study – Hyogo Sleep Cardio-Autonomic Atherosclerosis cohort study

Frontiers in Endocrinology, 2023
BackgroundAlthough excessive daytime napping has been shown to be involved in diabetes occurrence, its impact on insulin secretion and sensitivity has not been elucidated.
Miki Kakutani-Hatayama, Manabu Kadoya, Akiko Morimoto, Akio Miyoshi, Kae Kosaka-Hamamoto, Akinori Kanzaki, Kosuke Konishi, Yoshiki Kusunoki, Takuhito Syoji, Hidenori Koyama   +9 more
doaj   +1 more source