Results 41 to 50 of about 427,560 (316)

Nutritional modulation of insulin resistance [PDF]

, 2012
Insulin resistance has been proposed as the strongest single predictor for the development of Type 2 Diabetes (T2DM). Chronic oversupply of energy from food, together with inadequate physical activity, have been recognized as the most relevant factors ...
Weickert, Martin O., Martin O. Weickert
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Increased insulin resistance in intensive care: longitudinal retrospective analysis of glycaemic control patients in a New Zealand ICU

Therapeutic Advances in Endocrinology and Metabolism, 2021
Background: Critical care populations experience demographic shifts in response to trends in population and healthcare, with increasing severity and/or complexity of illness a common observation worldwide. Inflammation in critical illness impacts glucose–
Jennifer L. Knopp, J. Geoffrey Chase, Geoffrey M. Shaw   +2 more
doaj   +1 more source

Insulin Sensitivity and Albuminuria: The RISC Study [PDF]

Diabetes Care, 2014
OBJECTIVE Accumulating evidence suggests an association between insulin sensitivity and albuminuria, which, even in the normal range, is a risk factor for cardiovascular diseases. We evaluated whether insulin sensitivity is associated with albuminuria in healthy subjects.
Pilz, Stefan, Rutters, Femke, Nijpels, Giel, Stehouwer, Coen D A, Højlund, Kurt, Nolan, John J, Balkau, Beverley, Dekker, Jacqueline M   +7 more
openaire   +3 more sources

Impaired Insulin sensitivity and Insulin secretion in Haemodialysis patients with and without Secondary Hyperparathyroidism [PDF]

, 2004
The aim of our study was to investigate insulin sensitivity and beta cell function in hemodialysis (HD) patients without diabetes. We hypothesized that parathyroid gland function was a determinant of insulin sensitivity and/or beta cell function.
Pljesa, Steva, Komadina, Ljiljana, Milic, Natasa, Rasic-Milutinovic, Zorica, Gluvic, Zoran M., Perunicic-Pekovic, Gordana   +5 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Diabetes Mellitus, Extreme Insulin Resistance, and Hypothalamic-Pituitary Langerhans Cells Histiocytosis

Case Reports in Endocrinology, 2019
Background. Langerhans Cell Histiocytosis (LCH) is a rare inflammatory neoplasm characterized by an infiltration of organs by Langerin + (CD207+) and CD1a+ histiocytes.
Mathilde Sollier, Marine Halbron, Jean Donadieu, Ahmed Idbaih, Fleur Cohen Aubart, Corinne Vigouroux, Martine Auclair, Olivier Bourron, Marie Bastin, Géraldine Béra, Philippe Touraine, Jacques Young, Héléna Mosbah, Agnès Hartemann, Fabrizio Andreelli, Chloé Amouyal   +15 more
doaj   +1 more source

TCF7L2 correlation in both insulin secretion and postprandial insulin sensitivity

Diabetology & Metabolic Syndrome, 2018
Background The TCF7L2 rs7903146 variant is strongly associated with type 2 diabetes mellitus (T2DM). However, the mechanisms involved in this association remain unknown and may include extrapancreatic effects.
Mari Cassol Ferreira, Maria Elizabeth Rossi da Silva, Rosa Tsuneshiro Fukui, Maria do Carmo Arruda-Marques, Rosa Ferreira dos Santos   +4 more
doaj   +1 more source

Shape of the glucose response curve during an oral glucose tolerance test is associated with insulin clearance and muscle insulin sensitivity in healthy non‐obese men

Journal of Diabetes Investigation, 2020
Individuals with a monophasic glucose response curve (GRC) during a 75‐g oral glucose tolerance test have a higher risk for type 2 diabetes than those with a biphasic GRC.
Hideyoshi Kaga, Yoshifumi Tamura, Kageumi Takeno, Saori Kakehi, Yuki Someya, Takashi Funayama, Yasuhiko Furukawa, Ruriko Suzuki, Daisuke Sugimoto, Satoshi Kadowaki, Miho Nishitani‐Yokoyama, Kazunori Shimada, Hiroyuki Daida, Shigeki Aoki, Adria Giacca, Hiroaki Sato, Ryuzo Kawamori, Hirotaka Watada   +17 more
doaj   +1 more source

Evaluation of glucose tolerance test and surrogate indexes of insulin sensitivity to detect insulin resistance syndrome in transition dairy cows [PDF]

, 2013
Healthy multiparous Holstein-Fresian cows (n=101, parity ≥ 2) from 3 large-scale dairy herds in Italy were subjected to an intravenous glucose tolerance test (GTT) 14-1 d before (Week -1) and 3-9 d after calving (Week +1).
Riuzzi, Sara
core