Results 61 to 70 of about 427,560 (316)

Quantifying the improvement of surrogate indices of hepatic insulin resistance using complex measurement techniques [PDF]

, 2012
We evaluated the ability of simple and complex surrogate-indices to identify individuals from an overweight/obese cohort with hepatic insulin-resistance (HEP-IR).
Martin Osterhoff, Osterhoff Martin, Pfeiffer, Andreas F. H., Christian V Loeffelholz, Roden, Michael, Dr., Loeffelholz Christian v., Pfeiffer Andreas F. H., Nowotny, Peter, Möhlig Matthias, Nowotny Peter, Khan, Michael, Hattersley, John G., Weickert Martin O., Hierholzer, Johannes, Martin O Weickert, Arafat Ayman M., Roden Michael, Arafat, Ayman M., Machann Jürgen, Peter Nowotny, Weickert, Martin O., Möhlig, Matthias, Loeffelholz, Christian von, Hattersley John G., Michael Khan, Johannes Hierholzer, John G Hattersley, Matthias Möhlig, Michael Roden, Osterhoff, Martin, Khan Michael, Andreas F H Pfeiffer, Ayman M Arafat, Hierholzer Johannes, Jürgen Machann, Machann, Jürgen   +35 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion.

PLoS ONE, 2021
AimsInsulin sensitivity and insulin secretion can be estimated by multiple indices from fasting blood samples or blood samples obtained during oral glucose tolerance tests.
Sarah Hudak, Philipp Huber, Apostolia Lamprinou, Louise Fritsche, Norbert Stefan, Andreas Peter, Andreas L Birkenfeld, Andreas Fritsche, Martin Heni, Robert Wagner   +9 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Endurance training inhibits insulin clearance and IDE expression in Swiss mice. [PDF]

PLoS ONE, 2015
Endurance training improves peripheral insulin sensitivity in the liver and the skeletal muscle, but the mechanism for this effect is poorly understood.
José M Costa-Júnior, Sandra M Ferreira, André O Protzek, Gustavo J Santos, Ana P Cappelli, Leonardo R Silveira, Cláudio Zoppi, Camila A M de Oliveira, Antonio C Boschero, Everardo M Carneiro, Luiz F Rezende   +10 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Role of macrophages in exercise-induced enhancement of insulin sensitivity in skeletal muscle

Journal of Physical Fitness and Sports Medicine, 2013
Macrophage-induced inflammation is an important pathophysiological mechanism of insulin resistance, especially in adipose tissue. It has been demonstrated that exercise has anti-inflammatory effects and enhances insulin sensitivity in skeletal muscles ...
Shin-ichi Ikeda, Yoshifumi Tamura
doaj   +1 more source

Isoflurane and Sevoflurane Induce Severe Hepatic Insulin Resistance in a Canine Model. [PDF]

PLoS ONE, 2016
INTRODUCTION:Anesthesia induces insulin resistance, which may contribute to elevated blood glucose and adverse post-operative outcomes in critically ill patients, and impair glycemic control in surgical patients with diabetes.
Stella P Kim, Josiane L Broussard, Cathryn M Kolka   +2 more
doaj   +1 more source

Effect of Phenylbutazone Administration on Insulin Sensitivity in Horses With Insulin Dysregulation [PDF]

Background Phenylbutazone is prescribed to manage pain caused by hyperinsulinemia‐associated laminitis. Phenylbutazone reduces glucose and insulin concentrations in horses with insulin dysregulation (ID) but the underlying mechanism of action is unknown.
Bertin, François-René, François‐René Bertin, Kemp, Kate L., Nicholas K. Y. Yuen, Yuen, Nicholas K. Y., Kate L. Kemp, Jazmine E. Skinner, Skinner, Jazmine E.   +7 more
core   +1 more source