Results 51 to 60 of about 2,541,895 (309)

TCF7L2 correlation in both insulin secretion and postprandial insulin sensitivity

Diabetology & Metabolic Syndrome, 2018
Background The TCF7L2 rs7903146 variant is strongly associated with type 2 diabetes mellitus (T2DM). However, the mechanisms involved in this association remain unknown and may include extrapancreatic effects.
Mari Cassol Ferreira, Maria Elizabeth Rossi da Silva, Rosa Tsuneshiro Fukui, Maria do Carmo Arruda-Marques, Rosa Ferreira dos Santos   +4 more
doaj   +1 more source

Increased insulin resistance in intensive care: longitudinal retrospective analysis of glycaemic control patients in a New Zealand ICU

Therapeutic Advances in Endocrinology and Metabolism, 2021
Background: Critical care populations experience demographic shifts in response to trends in population and healthcare, with increasing severity and/or complexity of illness a common observation worldwide. Inflammation in critical illness impacts glucose–
Jennifer L. Knopp, J. Geoffrey Chase, Geoffrey M. Shaw   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Deep mutational scanning of the human insulin receptor ectodomain to inform precision therapy for insulin resistance

Nature Communications
The insulin receptor entrains tissue growth and metabolism to nutritional conditions. Complete loss of function in humans leads to extreme insulin resistance and infantile mortality, while loss of 80-90% function permits longevity of decades.
Vahid Aslanzadeh, Gemma V. Brierley, Rupa Kumar, Hasan Çubuk, Corinne Vigouroux, Kenneth A. Matreyek, Grzegorz Kudla, Robert K. Semple   +7 more
doaj   +1 more source

Shape of the glucose response curve during an oral glucose tolerance test is associated with insulin clearance and muscle insulin sensitivity in healthy non‐obese men

Journal of Diabetes Investigation, 2020
Individuals with a monophasic glucose response curve (GRC) during a 75‐g oral glucose tolerance test have a higher risk for type 2 diabetes than those with a biphasic GRC.
Hideyoshi Kaga, Yoshifumi Tamura, Kageumi Takeno, Saori Kakehi, Yuki Someya, Takashi Funayama, Yasuhiko Furukawa, Ruriko Suzuki, Daisuke Sugimoto, Satoshi Kadowaki, Miho Nishitani‐Yokoyama, Kazunori Shimada, Hiroyuki Daida, Shigeki Aoki, Adria Giacca, Hiroaki Sato, Ryuzo Kawamori, Hirotaka Watada   +17 more
doaj   +1 more source

Hypothesis: ‘Vasocrine’ signalling from perivascular fat - a mechanism linking insulin resistance and vascular disease [PDF]

, 2005
Adipose tissue expresses cytokines which inhibit insulin signalling pathways in liver and muscle. Obesity also results in impairment of endothelium-dependent vasodilatation to insulin. We propose a vasoregulatory role for local deposits of fat around the
Stehouwer, C.D.A., Eringa, E., Eringa, Etto, Stehouwer, C.D.A.; id_orcid, Eringa, E.C., Stehouwer, Coen D.A., Yudkin, J.S., Yudkin, John S.   +7 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipids

, 2003
Subjects with insulin resistance have been shown to have higher storage levels of intramyocellular lipid (IMCL) than their insulin-sensitive counterparts. It has been proposed that elevated IMCL stores may be the main cause of insulin resistance. The aim
Dornhorst, A., Hamilton, G., Goff, L.M., Frost, G.S., Thomas, E.L., Dhillo, W.S., Bell, J.D.   +6 more
core   +1 more source

Effect of insulin sensitivity on pulsatile insulin secretion [PDF]

European Journal of Endocrinology, 1999
OBJECTIVE: The aim of the study was to determine whether derangements in insulin pulsatility are related to the presence of insulin resistance or whether these changes occur only in non-insulin-dependent diabetes mellitus (NIDDM). DESIGN AND METHODS: The study included 26 obese, 11 NIDDM and 10 control subjects.
M, Zarković, J, Cirić, M, Stojanović, Z, Penezić, B, Trbojević, M, Dresgić, M, Nesović   +6 more
openaire   +2 more sources