Results 71 to 80 of about 2,541,895 (309)

Role of macrophages in exercise-induced enhancement of insulin sensitivity in skeletal muscle

Journal of Physical Fitness and Sports Medicine, 2013
Macrophage-induced inflammation is an important pathophysiological mechanism of insulin resistance, especially in adipose tissue. It has been demonstrated that exercise has anti-inflammatory effects and enhances insulin sensitivity in skeletal muscles ...
Shin-ichi Ikeda, Yoshifumi Tamura
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Effect of Avocado Soybean Unsaponifiables on Insulin Secretion and Insulin Sensitivity in Patients with Obesity

Obesity Facts, 2013
Aim: To evaluate the effect of avocado soybean unsaponifiables (ASU) on insulin secretion and insulin sensitivity in patients with obesity. Methods: A randomized, double-blind, placebo-controlled, clinical trial was carried out in 14 obese adult ...
Esperanza Martínez-Abundis, Manuel González-Ortiz, Arieh R. Mercado-Sesma, Claudia Reynoso-von-Drateln, Aureliano Moreno-Andrade   +4 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Insulin Sensitivity and beta-Cell Function in the Offspring of Type 2 Diabetic Patients: Impact of Line of Inheritance

Context: What defects in glucose metabolism are present in offspring of type 2 diabetic patients (FHD+ with a positive family history of diabetes) and to what extent they depend on line of inheritance are uncertain. Objective: The objective of this study
Walker M, Balkau B, Golay A, Insulin Sensitivity Cardiovasc Dis, Muscelli E, Anderwald C, Tura A, Ferrannini E, Natali A, Mari A   +9 more
core   +5 more sources

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Biomarkers of insulin sensitivity/resistance

Journal of International Medical Research
In recent years, remarkable advancements in elucidating the intricate molecular underpinnings of type 2 diabetes mellitus (T2D) have been achieved. Insulin resistance (IR) has been unequivocally acknowledged as the driving pathogenetic mechanism of T2D ...
Constantine E Kosmas, Andreas Sourlas, Konstantinos Oikonomakis, Eleni-Angeliki Zoumi, Aikaterini Papadimitriou, Christina E Kostara   +5 more
doaj   +1 more source

Palmitic Acid Reduces the Autophagic Flux and Insulin Sensitivity Through the Activation of the Free Fatty Acid Receptor 1 (FFAR1) in the Hypothalamic Neuronal Cell Line N43/5

Frontiers in Endocrinology, 2019
Chronic consumption of high fat diets (HFDs), rich in saturated fatty acids (SatFAs) like palmitic acid (PA), is associated with the development of obesity and obesity-related metabolic diseases such as type II diabetes mellitus (T2DM).
María Paz Hernández-Cáceres, María Paz Hernández-Cáceres, Lilian Toledo-Valenzuela, Lilian Toledo-Valenzuela, Francisco Díaz-Castro, Francisco Díaz-Castro, Yenniffer Ávalos, Yenniffer Ávalos, Paulina Burgos, Paulina Burgos, Carla Narro, Carla Narro, Daniel Peña-Oyarzun, Daniel Peña-Oyarzun, Daniel Peña-Oyarzun, Jasson Espinoza-Caicedo, Jasson Espinoza-Caicedo, Flavia Cifuentes-Araneda, Flavia Cifuentes-Araneda, Fernanda Navarro-Aguad, Cecilia Riquelme, Rodrigo Troncoso, Rodrigo Troncoso, Rodrigo Troncoso, Alfredo Criollo, Alfredo Criollo, Alfredo Criollo, Eugenia Morselli, Eugenia Morselli   +28 more
doaj   +1 more source