Results 71 to 80 of about 427,560 (316)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Effect of Avocado Soybean Unsaponifiables on Insulin Secretion and Insulin Sensitivity in Patients with Obesity

Obesity Facts, 2013
Aim: To evaluate the effect of avocado soybean unsaponifiables (ASU) on insulin secretion and insulin sensitivity in patients with obesity. Methods: A randomized, double-blind, placebo-controlled, clinical trial was carried out in 14 obese adult ...
Esperanza Martínez-Abundis, Manuel González-Ortiz, Arieh R. Mercado-Sesma, Claudia Reynoso-von-Drateln, Aureliano Moreno-Andrade   +4 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

The Effect of Heat Stress on Respiratory Alkalosis and Insulin Sensitivity in Cinnamon Supplemented Pigs

Animals, 2020
With increases in the frequency, intensity and duration of heat waves forecast plus expansion of tropical agriculture, heat stress (HS) is both a current and an emerging problem.
Jeremy J. Cottrell, John B. Furness, Udani A. Wijesiriwardana, Mitchell Ringuet, Fan Liu, Kristy DiGiacomo, Brian J. Leury, Iain J. Clarke, Frank R. Dunshea   +8 more
doaj   +1 more source

Metabolic effects of diets differing in glycaemic index depend on age and endogenous GIP [PDF]

, 2009
Aims/hypothesis High- vs low-glycaemic index (GI) diets unfavourably affect body fat mass and metabolic markers in rodents. Different effects of these diets could be age-dependent, as well as mediated, in part, by carbohydrate-induced stimulation of ...
Isken, Frank, Weickert, Martin O., Pfeiffer, Andreas F. H., Möhlig, Matthias, Abdelrahman, A., Thorens, B., Klaus, Susanne, Nogueiras, R., Tschöp, M. H.   +8 more
core   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer, Marie Obrecht, Charlotte de Maeseneire, Charlotte Damien, Chantal Depondt, Lorenzo Ferlini, Estelle Rikir, Filippo Annoni, Fabio Silvio Taccone, Nicolas Mavroudakis, Benjamin Legros, Nicolas Gaspard   +11 more
wiley   +1 more source

Palmitic Acid Reduces the Autophagic Flux and Insulin Sensitivity Through the Activation of the Free Fatty Acid Receptor 1 (FFAR1) in the Hypothalamic Neuronal Cell Line N43/5

Frontiers in Endocrinology, 2019
Chronic consumption of high fat diets (HFDs), rich in saturated fatty acids (SatFAs) like palmitic acid (PA), is associated with the development of obesity and obesity-related metabolic diseases such as type II diabetes mellitus (T2DM).
María Paz Hernández-Cáceres, María Paz Hernández-Cáceres, Lilian Toledo-Valenzuela, Lilian Toledo-Valenzuela, Francisco Díaz-Castro, Francisco Díaz-Castro, Yenniffer Ávalos, Yenniffer Ávalos, Paulina Burgos, Paulina Burgos, Carla Narro, Carla Narro, Daniel Peña-Oyarzun, Daniel Peña-Oyarzun, Daniel Peña-Oyarzun, Jasson Espinoza-Caicedo, Jasson Espinoza-Caicedo, Flavia Cifuentes-Araneda, Flavia Cifuentes-Araneda, Fernanda Navarro-Aguad, Cecilia Riquelme, Rodrigo Troncoso, Rodrigo Troncoso, Rodrigo Troncoso, Alfredo Criollo, Alfredo Criollo, Alfredo Criollo, Eugenia Morselli, Eugenia Morselli   +28 more
doaj   +1 more source

The effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males. [PDF]

, 2006
The purpose of this study was to investigate the effects of a submaximal aerobic exercise bout on adiponectin and resistin levels as well as insulin sensitivity, until 48 h post-exercise in healthy overweight males.
G. Koukoulis, N. Stakias, Koutedakis, Yiannis, Y. Koutedakis, Kouretas, Dimitris, Theocharis, V., V. Theocharis, Koutedakis, Y., D. Kouretas, Fatouros, I.G., Stakias, N., Fatouros, I. G., I. G. Fatouros, Kouretas, D., Jamurtas, A. Z., A. Z. Jamurtas, Jamurtas, Athanasios Z., Koukoulis, G.   +17 more
core   +1 more source