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"Insulin; Sense and Sensitivity"

, 2008
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Insulin Sensitizers

Mayo Clinic Proceedings, 2003
Type 2 diabetes mellitus is an increasingly prevalent disorder associated with multiple metabolic derangements. Insulin resistance is the most prominent feature common in both type 2 diabetes and its associated metabolic abnormalities. Until 1995, the only therapeutic interventions available in the United States were the insulin secretagogues ...
Farhad, Zangeneh, Yogish C, Kudva, Ananda, Basu   +2 more
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Insulin, insulin sensitivity and hypertension

Journal of Hypertension, 1990
The sensitivity of tissue to insulin is of physiological, pathophysiological and therapeutic relevance. The quantity of insulin and the response to insulin are paramount complementary factors in the regulation of glucose metabolism, and may, at least under certain pathophysiological conditions, also affect cardiovascular function.
Ferrari P, Weidmann P
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Insulin Resistance and Insulin Sensitizers

Hormone Research in Paediatrics, 2001
Insulin resistance is a key factor in the pathogenesis of type 2 diabetes mellitus and a co-factor in the development of dyslipidaemia, hypertension and atherosclerosis. The causes of insulin resistance include factors such as obesity and physical inactivity, and there may also be genetic factors.
M, Stumvoll, H, Häring
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Insulin sensitivity and fertility

Human Fertility, 2000
This review sets in context significant recent advances in the understanding of the pathophysiology of polycystic ovary syndrome (PCOS). The occurrence of variable insulin sensitivity in individuals is discussed. Information is presented to demonstrate that prolonged anovulation decreases insulin sensitivity and, conversely, that improvement in insulin
Roy, Taylor, Philippa J., Marsden
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Insulin sensitivity and hyperprolactinemia

Journal of Endocrinological Investigation, 2003
It has been shown that prolactin (PRL) induces glucose intolerance, hyperinsulinemia and insulin resistance in several animal species. In women with microprolactinomas, the sensitivity to insulin is lower in hyperprolactinemia than in normoprolactinemia.
Tuzcu, A, Bahceci, M, Dursun, M, Turgut, C, Bahceci, S   +4 more
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Insulin-sensitive obesity

American Journal of Physiology-Endocrinology and Metabolism, 2010
The association between obesity and impaired insulin sensitivity has long been recognized, although a subgroup of obese individuals seems to be protected from insulin resistance. In this study, we systematically studied differences in adipose tissue biology between insulin-sensitive (IS) and insulin-resistant (IR) individuals with ...
Nora, Klöting, Mathias, Fasshauer, Arne, Dietrich, Peter, Kovacs, Michael R, Schön, Matthias, Kern, Michael, Stumvoll, Matthias, Blüher   +7 more
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Captopril and Insulin Sensitivity

Annals of Internal Medicine, 1985
Excerpt To the editor: Captopril, an oral angiotensin converting enzyme inhibitor, is widely used in the treatment of patients with hypertension and chronic congestive heart failure, and to date no...
M, Ferriere, H, Lachkar, J L, Richard, J, Bringer, A, Orsetti, J, Mirouze   +5 more
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Zinc and insulin sensitivity

Biological Trace Element Research, 1992
Many studies have shown that zinc deficiency could decrease the response to insulin. In genetically diabetic animals, a low zinc status has been observed contrary to induced diabetic animals. The zinc status of human patients depends on the type of diabetes and the age.
P, Faure, A, Roussel, C, Coudray, M J, Richard, S, Halimi, A, Favier   +5 more
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Advances in Insulin Sensitizers

Current Medicinal Chemistry, 2004
Insulin resistance is the major cause in Non Insulin Dependent Diabetes Mellitus (NIDDM). In this review insulin production from beta-cells and action of insulin is briefly described. Any intervention either in the production or action of insulin has been the leading cause of NIDDM.
B B, Lohray, Vidya, Bhushan
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