Results 101 to 110 of about 422,788 (207)

Mechanisms linking glucotoxicity to the development of insulin resistance: a role for the endoplasmic reticulum stress

open access: yes, 2010
Aims/hypothesis: Glucosamine, generated during hyperglycaemia, causes insulin resistance in different cells. Here we sought to evaluate the possible role of ER stress in the induction of insulin-resistance by glucosamine in skeletal muscle cells. Methods:
Iadicicco, Claudia
core  

A central role for GRB10 in regulation of islet function in man

open access: yes, 2014
Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably ...
Osmond, C   +368 more
core   +1 more source

The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila

open access: yes, 2009
Insulin/IGF-like signalling (IIS) is an evolutionarily conserved pathway that has diverse functions in multi-cellular organisms. Mutations that reduce IIS can have pleiotropic effects on growth, development, metabolic homeostasis, fecundity, stress ...
Broughton, S.   +4 more
core  

Mechanisms and Pathophysiological Significance of Insulin Resistance in Offspring With Intrauterine Growth Restriction Mediated by Hepatic GR/miR‐1224 Programming

open access: yesAdvanced Science
Insulin resistance (IR) has fetal origin and gender preference. Here we traced glucose‐insulin phenotypical changes of intrauterine growth restriction (IUGR) female offspring at different ages and explore the mechanism.
Yongguo Dai   +5 more
doaj   +1 more source

Optical Nanosensor Architecture for Cell-Signaling Molecules Using DNA Aptamer-Coated Carbon Nanotubes

open access: yes, 2011
We report a novel optical biosensor platform using near-infrared fluorescent single-walled carbon nanotubes (SWNTs) functionalized with target-recognizing aptamer DNA for noninvasively detecting cell-signaling molecules In real time.
Rickus, Jenna   +15 more
core   +1 more source

The transcription complex Prep1-Pbx1 regulates the gene expression of tyrosine phosphatases and impairs insulin action in liver cells

open access: yes, 2009
Prep1 is an homeodomain transcription factor belonging to the MEINOX subfamily of the TALE (three amino acid loop extension) proteins. Prep1 forms DNA-independent dimeric complexes with all isoforms of the Pbx homeodomain transcription factor, enhancing ...
Iovino, Salvatore
core  

Efeito do estrito controle da glicemia sobre parâmetros neuroquímicos em animais hiperglicêmicos [PDF]

open access: yes, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduaçao em Bioquímica, Florianópolis, 2013O diabetes mellitus (DM) é uma síndrome metabólica de etiologia múltipla caracterizada por ...
Matos, Filipe José de
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The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice

open access: yes, 2008
Background Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. The development of these metabolic disorders is frequently studied, but mainly in liver, skeletal muscle, and adipose tissue.
Mechteld M Grootte Bromhaar   +34 more
core   +1 more source

Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium

open access: yes, 2008
Includes abstract.Includes bibliographical references (p. 89-106).Regular exercise protects individuals against developing insulin resistance and type II diabetes.
Smith, James Antony Harris
core  

Caracterização do efeito e de vias de sinalização de compostos presentes em Ilex paraguariensis St. Hil. envolvidas na homeostasia da glicose [PDF]

open access: yes, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015.A manutenção das concentrações homeostáticas de glicose no sangue é essencial para o bem-estar de ...
Postal, Bárbara Graziela
core  

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