Results 81 to 90 of about 422,788 (207)

The level of mendione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion

, 2012
Pancreatic β-cells release insulin in response to elevation of glucose from basal (4–7 mM) to stimulatory (8–16 mM) levels. Metabolism of glucose by the β-cell results in the production of low levels of reactive oxygen intermediates (ROI), such as ...
Womack, Trayce, Gray, Joshua P., Joshua P. Gray, Peter J.S. Smith, Smith, Peter J. S., Meridith Palo, Heart, Emma, Trayce Womack, Emma Heart   +8 more
core   +1 more source

Insulin Signaling as a Key Moderator in Myotonic Dystrophy Type 1

Frontiers in Neurology, 2019
Myotonic dystrophy type 1 (DM1) is an autosomal dominant genetic disease characterized by multi-system involvement. Affected organ system includes skeletal muscle, heart, gastro-intestinal system and the brain.
Sylvia Nieuwenhuis, Kees Okkersen, Joanna Widomska, Paul Blom, Peter A. C. 't Hoen, Baziel van Engelen, Jeffrey C. Glennon   +6 more
doaj   +1 more source

Comprehensive assessment of expression of insulin signaling pathway components in subcutaneous adipose tissue of women with and without polycystic ovary syndrome

Journal of Clinical & Translational Endocrinology, 2015
Objective: Insulin resistance is a common feature of polycystic ovary syndrome (PCOS). The insulin signaling pathway consists of two major pathways, the metabolic and the mitogenic cascades.
Ning Xu, David H. Geller, Michelle R. Jones, Vincent A. Funari, Ricardo Azziz, Mark O. Goodarzi   +5 more
doaj   +1 more source

Insulin Signaling in Health and Disease [PDF]

Science, 2003
The signaling pathways used by insulin have been identified [M. White, Insulin Signaling Pathway, Sci. STKE (Connections Map, as seen November 2003), http://stke.sciencemag.org/cgi/cm/cmp_12069 ].
openaire   +2 more sources

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice [PDF]

, 2011
Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease).
Burgess, Laura A, Howlett, David R, Meakin, PJ, Vaanholt, Lobke M, Hamilton, DL, Vaanholt, Lobke M., Judy Latcham, Burgess, Laura A., Alison D. McNeilly, Burgess, LA, Michael L.J. Ashford, D. Lee Hamilton, Lobke M. Vaanholt, Kirsten A. Bannon, Ashford, MLJ, David R. Howlett, Speakman, John R, McNeilly, Alison D, Alex J. Harper, John R. Speakman, Ashford, Michael L J, Speakman, John R., Gallagher, J, Hamilton, David Lee, McNeilly, Alison D.; id_orcid, Hussain, Ishrut, Hamilton, D. Lee, Meakin, Paul J.; id_orcid, Latcham, J, Harper, Alex J, Bannon, KA, McNeilly, AD, Jennifer Gallagher, Latcham, Judy, Howlett, DR, Ashford, Michael L. J.; id_orcid, Vaanholt, LM, Hussain, I, Gallagher, Jennifer, Harper, Alex J., Bannon, Kirsten A., Paul J. Meakin, Bannon, Kirsten A, Ishrut Hussain, Harper, AJ, Meakin, Paul J, Laura A. Burgess, Howlett, David R., Speakman, JR   +48 more
core   +1 more source

Visfatin Induces Inflammation and Insulin Resistance via the NF-κB and STAT3 Signaling Pathways in Hepatocytes

Journal of Diabetes Research, 2019
Background. It has been suggested that visfatin, which is an adipocytokine, exhibits proinflammatory properties and is associated with insulin resistance.
Yu Jung Heo, Sung-E Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim   +7 more
doaj   +1 more source

Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes

Molecular Metabolism, 2019
Objective: Accumulation of visceral white adipose tissue (WAT) associates with insulin resistance, adipose tissue inflammation, and metabolic syndrome, whereas accumulation of subcutaneous WAT may be protective.
Alfred K. Ramirez, Simon Dankel, Weikang Cai, Masaji Sakaguchi, Simon Kasif, C. Ronald Kahn   +5 more
doaj   +1 more source

Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data

, 2012
Background: Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. However little is known about early changes in the diabetic heart and the impact of insulin treatment (Ins).
Günter AJ Riegger, Sabine Fredersdorf, Vetter, Roland, Eschenhagen, Thomas, Weil, Joachim, Joachim Weil, Thumann, Christian, Wolfram H Zimmermann, Heribert Schunkert, Riegger, Günter A. J., Luchner, Andreas, Luchner Andreas, Vetter Roland, Zimmermann, Wolfram-Hubertus, Graf, Tobias, Schunkert, Heribert, Thumann Christian, Andreas Luchner, Weil Joachim, Fredersdorf Sabine, Roland Vetter, Schunkert Heribert, Eschenhagen Thomas, Tobias Graf, Graf Tobias, Zimmermann, Wolfram H., Thomas Eschenhagen, Zimmermann Wolfram H, Christian Thumann, Riegger, Guenter A. J., Fredersdorf, Sabine, Riegger Günter AJ   +31 more
core   +1 more source

Divergent Role of Sphingosine 1-Phosphate on Insulin Resistance

Cellular Physiology and Biochemistry, 2014
Insulin resistance is a complex metabolic disorder in which insulin-sensitive tissues fail to respond to the physiological action of insulin. There is a strong correlation of insulin resistance and the development of type 2 diabetes both reaching ...
Susann Fayyaz, Lukasz Japtok, Burkhard Kleuser   +2 more
doaj   +1 more source

Deletion of LPCAT3 Promotes Enhanced Insulin Signaling in Skeletal Muscle

, 2023
Aberrant lipid metabolism has been linked to skeletal muscle insulin resistance. The exact identity of the lipid species that promote skeletal muscle insulin resistance among the human population remains unclear.
NC DOCKS at East Carolina University, Ferrara, Patrick J.   +1 more
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