Results 61 to 70 of about 422,788 (207)

Systems biology approach reveals genome to phenome correlation in type 2 diabetes.

PLoS ONE, 2013
Genome-wide association studies (GWASs) have discovered association of several loci with Type 2 diabetes (T2D), a common complex disease characterized by impaired insulin secretion by pancreatic β cells and insulin signaling in target tissues.
Priyanka Jain, Saurabh Vig, Malabika Datta, Dinesh Jindel, Ashok Kumar Mathur, Sandeep Kumar Mathur, Abhay Sharma   +6 more
doaj   +1 more source

Brain insulin signaling and cognition

EXCLI Journal : Experimental and Clinical Sciences, 2023
Poor cognitive ability is a consequence of a wide variety of neurobehavioral disorders and is a growing health problem, especially among the elderly and patients with diabetes.
Habib Yaribeygi, Mina Maleki, Alexandra E. Butler, Tannaz Jamialahamdi, Amirhossein Sahebkar   +4 more
doaj   +1 more source

Tissue-specific insulin signaling mediates female sexual attractiveness.

PLoS Genetics, 2017
Individuals choose their mates so as to maximize reproductive success, and one important component of this choice is assessment of traits reflecting mate quality.
Tatyana Y Fedina, Devin Arbuthnott, Howard D Rundle, Daniel E L Promislow, Scott D Pletcher   +4 more
doaj   +1 more source

Regulation of insect behavior via the insulin-signaling pathway

Frontiers in Physiology, 2013
The insulin/insulin-like growth factor signaling (IIS) pathway is well established as a critical regulator of growth and metabolic homeostasis across the animal kingdom.
Renske eErion, Amita eSehgal
doaj   +1 more source

Associations of insulin and insulin-like growth factors with physical performance in old age in the boyd orr and caerphilly studies. [PDF]

, 2012
OBJECTIVE: Insulin and the insulin-like growth factor (IGF) system regulate growth and are involved in determining muscle mass, strength and body composition.
David Gunnell, Gunnell, David, Gallacher, John, Martin, Richard M., Birnie, K, Gunnell, D, Kate Birnie, Gunnell David, Antony Bayer, Bayer Antony, John Gallacher, Ebrahim, S, Holly, Jeff MP, Bayer, A, Yoav Ben-Shlomo, Birnie Kate, Shah Ebrahim, Ben-Shlomo, Y, Ebrahim, Shah, Jeff M P Holly, Gunnell, DJ, Gallacher, J, Martin, Richard M, Holly, JM, Bayer, Antony, Jeff M. P. Holly, Martin Richard M., Martin, RM, Richard M Martin, Richard M. Martin, Holly Jeff M. P., Gallacher John, Holly, JMP, Holly, Jeff M. P., Bayer, Antony James, Birnie, Kate, Ben-Shlomo, Yoav, Ben-Shlomo Yoav, Ebrahim Shah, Gallacher, John Edward   +39 more
core   +1 more source

Beta cell dysfunction and insulin resistance

Frontiers in Endocrinology, 2013
Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states induce hyperglycemia and therefore increase insulin demand. Beta cell
Marlon E Cerf
doaj   +1 more source

Current Studies on Molecular Mechanisms of Insulin Resistance

Journal of Diabetes Research, 2022
Diabetes is a metabolic disease that raises the risk of microvascular and neurological disorders. Insensitivity to insulin is a characteristic of type II diabetes, which accounts for 85-90 percent of all diabetic patients.
Jinli Pei, Baochun Wang, Dayong Wang
doaj   +1 more source

Mechanisms Linking Inflammation to Insulin Resistance

International Journal of Endocrinology, 2015
Obesity is now widespread around the world. Obesity-associated chronic low-grade inflammation is responsible for the decrease of insulin sensitivity, which makes obesity a major risk factor for insulin resistance and related diseases such as type 2 ...
Li Chen, Rui Chen, Hua Wang, Fengxia Liang   +3 more
doaj   +1 more source

Insulin signaling

Science, 1997
The following article is another in a series of papers presented at the Annual Meeting of the Western Association of Physicians. The WAP meets in Carmel, usually in the first week of February, along with sister organization the Western Society for Clinical Investigation and the Western Federation for Clinical Research.
M L, Goalstone, B, Draznin
openaire   +3 more sources

BACH1 controls hepatic insulin signaling and glucose homeostasis in mice

Nature Communications, 2023
Hepatic insulin resistance is central to the metabolic syndrome. Here we investigate the role of BTB and CNC homology 1 (BACH1) in hepatic insulin signaling. BACH1 is elevated in the hepatocytes of individuals with obesity and patients with non-alcoholic
Jiayu Jin, Yunquan He, Jieyu Guo, Qi Pan, Xiangxiang Wei, Chen Xu, Zhiyuan Qi, Qinhan Li, Siyu Ma, Jiayi Lin, Nan Jiang, Jinghua Ma, Xinhong Wang, Lindi Jiang, Qiurong Ding, Elena Osto, Xiuling Zhi, Dan Meng   +17 more
doaj   +1 more source