Results 51 to 60 of about 422,788 (207)

IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells [PDF]

, 2012
The cysteine-type peptidase cathepsin X is highly upregulated in several cancers and presumably promotes tumor invasion through bypassing cellular senescence. Here, we present first evidence that the underlying mechanism may involve the regulation of the
Kraus, Steffen, Bunsen, Thea, Fruth, Maximilian, Nägler, Dorit K.   +3 more
core   +1 more source

Insulin signaling in health and disease [PDF]

Journal of Clinical Investigation, 2021
The molecular mechanisms of cellular insulin action have been the focus of much investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in metabolic syndrome, a condition known as insulin resistance. The actions of the hormone are initiated by binding to its receptor on the surface of target cells.
openaire   +4 more sources

Insulin, Insulin Resistance, and Platelet Signaling in Diabetes [PDF]

Diabetes Care, 2009
Insulin resistance and the metabolic syndrome are associated with a prothrombotic state that contributes to the pathogenesis and progression of the vascular complications of type 2 diabetes. Development of the disease is also linked to the loss of the direct antiplatelet effect of insulin and platelets obtained from patients with diabetes who are ...
Randriamboavonjy, Voahanginirina, Fleming, Ingrid   +1 more
openaire   +2 more sources

Insulin Signaling and Heart Failure [PDF]

Circulation Research, 2016
Heart failure is associated with generalized insulin resistance. Moreover, insulin-resistant states such as type 2 diabetes mellitus and obesity increases the risk of heart failure even after adjusting for traditional risk factors. Insulin resistance or type 2 diabetes mellitus alters the systemic and neurohumoral milieu, leading to changes in ...
Christian, Riehle, E Dale, Abel
openaire   +2 more sources

iNOS promotes hypothalamic insulin resistance associated with deregulation of energy balance and obesity in rodents

Scientific Reports, 2017
Inducible nitric oxide (iNOS)-mediated S-nitrosation of the metabolic signaling pathway has emerged as a post-translational modification that triggers insulin resistance in obesity and aging.
Carlos Kiyoshi Katashima, Vagner Ramon Rodrigues Silva, Luciene Lenhare, Rodrigo Miguel Marin, José Barreto Campello Carvalheira   +4 more
doaj   +1 more source

Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]

, 2009
Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Boyd, Alasdair R., Stuart A. Ritchie, Ian P. Salt, Salt, Ian P., Kohlhaas, Christine F, Yalla, Krishna C, Kohlhaas, Christine F., Boyd, Alasdair R, Krishna C. Yalla, Walsh, Kenneth, Ritchie, Stuart A, John M. C. Connell, Christine F. Kohlhaas, Kenneth Walsh, Ritchie, Stuart A., Connell, John M.C., Connell, John Mc, Salt, Ian P, Alasdair R. Boyd, Yalla, Krishna C.   +19 more
core   +1 more source

RETRACTED ARTICLE: Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome

Nature Communications, 2023
Downregulation of endothelial Sirtuin1 (Sirt1) in insulin resistant states contributes to vascular dysfunction. Furthermore, Sirt1 deficiency in skeletal myocytes promotes insulin resistance.
Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S. Jacobs, Markus M. Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J. Rauckhorst, Eric B. Taylor, Andrew W. Norris, Ajit Vikram, Kaikobad Irani   +14 more
doaj   +1 more source

Investigating the role of Class-1 Phosphoinositide 3 Kinases (PI3Ks) in insulin signaling and obesity [PDF]

, 2020
Obesity and obesity related diseases such as type 2 diabetes, cardiovascular disorders, and different types of cancer are leading causes of mortality and morbidity in modern society.
Molinaro, Angela
core   +1 more source

Insulin Signaling in a Bit of a Jam [PDF]

Cell, 2016
In this issue of Cell, Okin and Medzhitov report that sustained inflammation promotes hyperglycemia by targeting the mevalonate pathway. This represents an important step forward in understanding the mechanisms underlying the association between chronic low-grade inflammation and disruption of normal tissue functions in metabolic diseases.
Vassily I, Kutyavin, Ajay, Chawla
openaire   +2 more sources

LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance

Nature Communications
Obesity impairs tissue insulin sensitivity and signaling, promoting type-2 diabetes. Although improving insulin signaling is key to reversing diabetes, the multi-organ mechanisms regulating this process are poorly defined.
Olga Kubrak, Anne F. Jørgensen, Takashi Koyama, Mette Lassen, Stanislav Nagy, Jacob Hald, Gianluca Mazzoni, Dennis Madsen, Jacob B. Hansen, Martin Røssel Larsen, Michael J. Texada, Jakob L. Hansen, Kenneth V. Halberg, Kim Rewitz   +13 more
doaj   +1 more source