Results 71 to 80 of about 422,788 (207)

Insulin enables acquisition of the IL7R+ memory phenotype in PD1+ T cells in RA tissues

Cell Death and Disease
Insulin signaling regulates cellular metabolism in an epigenetic manner, but its role in the immune cell homeostasis remains unknown. High plasma insulin obstructs efficient insulin signaling and rewires metabolic activity in autoimmunity. In this study,
Venkataragavan Chandrasekaran, Malin C. Erlandsson, David Svensson, Eric Malmhäll-Bah, Sofia Töyrä Silfverswärd, Rille Pullerits, Gergely Katona, Maria I. Bokarewa   +7 more
doaj   +1 more source

Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P3 Production and Akt Activation

Cell Reports, 2018
Summary: In obese adipose tissue, Toll-like receptor signaling in macrophages leads to insulin resistance in adipocytes. Similarly, Toll signaling in the Drosophila larval fat body blocks insulin-dependent growth and nutrient storage.
Stephen W. Roth, Moshe D. Bitterman, Morris J. Birnbaum, Michelle L. Bland   +3 more
doaj   +1 more source

High-Fat Diet : Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse [PDF]

, 2010
Background: Obesity induced by high fat (HF) diet is associated with inflammation which contributes to development of insulin resistance. Most prior studies have focused on adipose tissue as the source of obesity-associated inflammation.
Michael M Chi, Scott Magness, Jobin, Christian, Christian Jobin, Jobin Christian, Scull Brooks P., Brooks P. Scull, Lund Pauline K., Chi Michael M., Magness Scott, Shengli Ding, Pauline K Lund, Scull, Brooks P., Nicole M. J. Schwerbrock, Brooks P Scull, Nicole M J Schwerbrock, Chi, Michael M., Ding Shengli, Magness, Scott, Rigby Rachael, Schwerbrock, Nicole M. J., Schwerbrock Nicole M. J., Rigby, Rachael, Ding, Shengli, Lund, Pauline K., Michael M. Chi, Pauline K. Lund, Rachael Rigby   +27 more
core   +1 more source

E4orf1 induction in adipose tissue promotes insulin-independent signaling in the adipocyte

Molecular Metabolism, 2015
Background/Purpose: Type 2 diabetes remains a worldwide epidemic with major pathophysiological changes as a result of chronic insulin resistance. Insulin regulates numerous biochemical pathways related to carbohydrate and lipid metabolism.
Christine M. Kusminski, Violeta I. Gallardo-Montejano, Zhao V. Wang, Vijay Hegde, Perry E. Bickel, Nikhil V. Dhurandhar, Philipp E. Scherer   +6 more
doaj   +1 more source

Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3. [PDF]

PLoS ONE, 2010
Hepatitis B virus (HBV) is a major cause of chronic liver diseases, and frequently results in hepatitis, cirrhosis, and ultimately hepatocellular carcinoma. The role of HCV in associations with insulin signaling has been elucidated.
KyeongJin Kim, Kook Hwan Kim, JaeHun Cheong   +2 more
doaj   +1 more source

Chromium chloride increases insulin-stimulated glucose uptake in the perfused rat hindlimb [PDF]

, 2010
textChromium has been reported to increase glucose clearance in insulin resistant and diabetic populations. Skeletal muscle is the tissue primarily responsible for glucose clearance. We therefore tested the effect of chromium chloride (CrCl3) on skeletal
Doerner, Phillip Gene
core  

Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling

, 2001
The "metabolic cocktail" comprising glucose-insulin-potassium administrated at reperfusion reduces infarct size in the in vivo rat heart. We propose that insulin is the major component mediating this protection and acts via Akt prosurvival signaling ...
Sack, M.N., Yellon, D.M., Jonassen, A.K., Mjøs, O.D.   +3 more
core  

Avaliação de proteínas chaves envolvidas nas vias insulínica e inflamatória e do receptor de glicocorticoide em tecido adiposo de ratos tratados com dexametasona [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, Florianópolis, 2014.É sabido que os glicocorticoides (GCs) podem diminuir a sensibilidade ...
Motta, Katia
core  

mTOR complex 2 - akt signaling is physically and functionally at mam [PDF]

, 2012
The target of rapamycin (TOR) is a conserved protein kinase and a central controller of growth. TOR can be part of two structurally and functionally distinct complexes, termed TOR complex 1 and TOR complex 2.
Betz, Charles
core   +1 more source

Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models

, 2011
The most common risk factors for chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC) include chronic alcohol abuse and infection with hepatitis B (HBV) or hepatitis C (HCV) virus.
Setshedi, Mashiko
core