Results 41 to 50 of about 422,788 (207)

Expression of a constitutively active insulin receptor in Drosulfakinin (Dsk) neurons regulates metabolism and sleep in Drosophila

Biochemistry and Biophysics Reports, 2022
The ability of organisms to sense their nutritional environment and adjust their behavior accordingly is critical for survival. Insulin-like peptides (ilps) play major roles in controlling behavior and metabolism; however, the tissues and cells that ...
Justin Palermo, Alex C. Keene, Justin R. DiAngelo   +2 more
doaj   +1 more source

Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs [PDF]

, 2008
The insulin/IGF-like signalling (IIS) pathway has diverse functions in all multicellular organisms, including determination of lifespan. The seven insulin-like peptides (DILPs) in Drosophila are expressed in a stage- and tissue-specific manner.
Driege, Y., Driege Yasmine, Broughton, S, Broughton, Susan, Tommasi, AM, Partridge Linda, Hafen, Ernst, Cathy Slack, Tommasi Anna Maria, Anna Maria Tommasi, Slack, C, Broughton, S., Hafen, E., Nazif Alic, Broughton Susan, Alic, N, Partridge, Linda, Vinti Giovanna, Ikeya, T., Driege, Y, Giovanna Vinti, Ikeya Tomoatsu, Tomoatsu Ikeya, Alic, N., Bass, Timothy, Bass, T., Slack Cathy, Vinti, Giovanna, Linda Partridge, Herman, Christophe, Partridge, L., Timothy Bass, Ikeya, T, Tommasi, Anna Maria, Bass Timothy, Hafen Ernst, Alic Nazif, Hafen, E, Susan Broughton, Driege, Yasmine, Ernst Hafen, Slack, Cathy, Bass, T, Alic, Nazif, Ikeya, Tomoatsu, Partridge, L, Vinti, G, Tommasi, A.M., Slack, C., Yasmine Driege, Vinti, G.   +50 more
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Insulin-signaling pathway acting downstream of DAF-2 receptors.

, 2022
(A) Schematic of a neuron’s daf-2-mediated canonical and non-canonical insulin signaling. Summary of the findings in B. Created with Biorender.com (B) Standard sensory integration assay performed with mutants in the canonical insulin signaling pathway ...
Hiu E. Lau (12505892), Anupama Singh (414518), Malene Hansen (10367), Karina Kono (4164274), Jessica A. Haley (12505895), Molly A. Matty (6432926), Kirthi C. Reddy (12505901), Sreekanth H. Chalasani (3291729), Ahana Chakraborty (12505898)   +8 more
core   +1 more source

Insulin signalling and GLUT4 trafficking in insulin resistance

Biochemical Society Transactions, 2023
Insulin-stimulated glucose uptake into muscle and adipose tissue is vital for maintaining whole-body glucose homeostasis. Insulin promotes glucose uptake into these tissues by triggering a protein phosphorylation signalling cascade, which converges on multiple trafficking processes to deliver the glucose transporter GLUT4 to the cell surface.
Van Gerwen, Julian, Shun-Shion, Amber S, Fazakerley, Daniel J   +2 more
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Atorvastatin improves survival in septic rats: effect on tissue inflammatory pathway and on insulin signaling. [PDF]

PLoS ONE, 2010
The aim of the present study was to investigate whether the survival-improving effect of atorvastatin in sepsis is accompanied by a reduction in tissue activation of inflammatory pathways and, in parallel, an improvement in tissue insulin signaling in ...
Kelly Lima Calisto, Bruno de Melo Carvalho, Eduardo Rochete Ropelle, Francine Cappa Mittestainer, Angélica Costa Aranha Camacho, Dioze Guadagnini, José Barreto Campelo Carvalheira, Mario José Abdalla Saad   +7 more
doaj   +1 more source

Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines

Mediators of Inflammation, 2018
We have previously reported that Epac1 reduced inflammatory cytokines, which is protective to the diabetic retina. We have also published that impaired insulin signaling occurs in the diabetic retina.
Elizabeth Curtiss, Youde Jiang, Li Liu, Claire Hawthorne, Jessica Zhang, Jena J. Steinle   +5 more
doaj   +1 more source

NUCKS Is a Positive Transcriptional Regulator of Insulin Signaling

Cell Reports, 2014
Although much is known about the molecular players in insulin signaling, there is scant information about transcriptional regulation of its key components.
Beiying Qiu, Xiaohe Shi, Ee Tsin Wong, Joy Lim, Marco Bezzi, Diana Low, Qiling Zhou, Semih Can Akıncılar, Manikandan Lakshmanan, Hannah L.F. Swa, Jill Mae Lan Tham, Jayantha Gunaratne, Kenneth K.Y. Cheng, Wanjin Hong, Karen S.L. Lam, Masahito Ikawa, Ernesto Guccione, Aimin Xu, Weiping Han, Vinay Tergaonkar   +19 more
doaj   +1 more source

Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk [PDF]

, 2010
Drosophila Lnk is the single ancestral orthologue of a highly conserved family of structurally-related intracellular adaptor proteins, the SH2B proteins.
Linda Partridge, Partridge, L., Withers, D., Stocker, H, Withers, D.J., Foley, A., Foley, Andrea, Hafen, Ernst, Cathy Slack, Thornton, Janet M., Werz, C, Wieser, D, Stocker, Hugo, Thornton, J., Slack, C, Wieser, D., Werz, C., Hafen, E, Withers, Dominic J., Hafen, E., Lu, Bingwei, Dominic J Withers, Nazif Alic, Janet M Thornton, Werz, Christian, Alic, N, Stocker, H., Withers, DJ, Ernst Hafen, Partridge, Linda, Slack, Cathy, Hugo Stocker, Andrea Foley, Wieser, Daniela, Foley, A, Alic, Nazif, Partridge, L, Christian Werz, Thornton, JM, Alic, N., Daniela Wieser, Slack, C., Lu, B., Thornton, J. M.   +43 more
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Perturbation of IIS/TOR signaling alters the landscape of sex-differential gene expression in Drosophila

BMC Genomics, 2018
Background The core functions of the insulin/insulin-like signaling and target of rapamycin (IIS/TOR) pathway are nutrient sensing, energy homeostasis, growth, and regulation of stress responses.
Rita M. Graze, Ruei-Ying Tzeng, Tiffany S. Howard, Michelle N. Arbeitman   +3 more
doaj   +1 more source

Endothelial Notch signaling controls insulin transport in muscle

EMBO Molecular Medicine, 2020
The role of the endothelium is not just limited to acting as an inert barrier for facilitating blood transport. Endothelial cells (ECs), through expression of a repertoire of angiocrine molecules, regulate metabolic demands in an organ‐specific manner ...
Sana S Hasan, Markus Jabs, Jacqueline Taylor, Lena Wiedmann, Thomas Leibing, Viola Nordström, Giuseppina Federico, Leticia P Roma, Christopher Carlein, Gretchen Wolff, Bilgen Ekim‐Üstünel, Maik Brune, Iris Moll, Fabian Tetzlaff, Hermann‐Josef Gröne, Thomas Fleming, Cyrill Géraud, Stephan Herzig, Peter P Nawroth, Andreas Fischer   +19 more
doaj   +1 more source