Results 21 to 30 of about 422,788 (207)
The insulin signalling pathway [PDF]
Current Biology, 2002 A key aim for future research is to identify the hydrophobic motif kinase that phosphorylates PKB, S6K, SGK and to establish how this protein kinase(s) is regulated by PtdIns(3,4,5)P3. It is also becoming obvious that the information obtained by the overexpression of constitutively active and dominant negative mutants of protein kinases is not ...
Lizcano, Jose M., Alessi, Dario R.
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Insulin Signaling and Insulin Resistance [PDF]
Journal of Investigative Medicine, 2013 Insulin resistance or its sequelae may be the common etiology of maladies associated with metabolic syndrome (eg, hypertension, type 2 diabetes, atherosclerosis, heart attack, stroke, and kidney failure). It is thus important to understand those factors that affect insulin sensitivity.
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Insulin Signal Transduction Perturbations in Insulin Resistance [PDF]
International Journal of Molecular Sciences, 2021 Type 2 diabetes mellitus is a widespread medical condition, characterized by high blood glucose and inadequate insulin action, which leads to insulin resistance. Insulin resistance in insulin-responsive tissues precedes the onset of pancreatic β-cell dysfunction.
Mariyam Khalid +3 more
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The brain as an insulin-sensitive metabolic organ
Molecular Metabolism, 2021 Background: The brain was once thought of as an insulin-insensitive organ. We now know that the insulin receptor is present throughout the brain and serves important functions in whole-body metabolism and brain function.
Joshua L. Milstein, Heather A. Ferris
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Molecular evolution and functional characterization of Drosophila insulin-like peptides [PDF]
, 2010 Multicellular animals match costly activities, such as growth and reproduction, to the environment through nutrient-sensing pathways. The insulin/IGF signaling (IIS) pathway plays key roles in growth, metabolism, stress resistance, reproduction, and ...
Gronke, S +20 more
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The role of C-peptide in regulation of the insulin signaling system (systematic review)
Сибирский научный медицинский журнал, 2021 The C-peptide is a fragment of proinsulin, the cleavage of which forms active insulin. In recent years, new evidence has emerged indicating that C-peptide is involved not only in the processing of insulin in the secretory granules of pancreatic β-cells ...
O. N. Poteryaeva, I. F. Usynin
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Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling [PDF]
Cell MetabolismKyle D Copps +2 more
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Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling
Molecular Brain, 2018 Chronic stress is a psychologically significant factor that impairs learning and memory in the hippocampus. Insulin signaling is important for the development and cognitive function of the hippocampus.
Hanwoong Woo +4 more
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The role of systemically perturbed PTEN and PKBß/AKT2 signaling in accumulation of hepatic lipids [PDF]
, 2013 Non-alcoholic fatty liver disease (NAFLD) is a major health problem and occurs frequently in the context of obesity and type 2 diabetes mellitus (T2D).
Schultze, Simon Manuel
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Adipokines and redox signaling: impact on fatty liver disease. [PDF]
, 2011 Adipokines (adipose tissue cytokines) are polypeptide factors secreted by adipose tissue in a highly regulated manner. The 'classical' adipokines (leptin, adiponectin, and resistin) are expressed only by adipocytes, but other adipokines have been shown ...
Marra, Fabio. +2 more
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