Results 11 to 20 of about 422,788 (207)
Insulin Signaling in Arthritis [PDF]
Frontiers in Immunology, 2021 Inflammatory arthritis is burdened by an increased risk of metabolic disorders. Cytokines and other mediators in inflammatory diseases lead to insulin resistance, diabetes and hyperlipidemia.
Cesare Tripolino +10 more
doaj +5 more sources
Insulin signaling and autism [PDF]
Frontiers in Endocrinology, 2011 Autism and autism spectrum disorders (ASDs) are thought to be caused mostly by genetic factors with an additional contribution from unidentified environmental risk factors. Identifying these environmental risk factors could improve both prevention and development of therapeutics, but the nature of these factors is not well understood.
Michael eStern
doaj +3 more sources
Insulin signaling and addiction [PDF]
Neuropharmacology, 2011 Across species, the brain evolved to respond to natural rewards such as food and sex. These physiological responses are important for survival, reproduction and evolutionary processes. It is no surprise, therefore, that many of the neural circuits and signaling pathways supporting reward processes are conserved from Caenorhabditis elegans to ...
Lynette C, Daws +5 more
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Insulin signalling in the heart [PDF]
Cardiovascular Research, 2008 The main role of insulin in the heart under physiological conditions is obviously the regulation of substrate utilization. Indeed, insulin promotes glucose uptake and its utilization via glycolysis. In addition, insulin participates in the regulation of long-chain fatty acid uptake, protein synthesis, and vascular tonicity.
Luc, Bertrand +3 more
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Decoding the Insulin Signal [PDF]
Molecular Cell, 2012 In this issue of Molecular Cell, Kubota et al. (2012) show how different temporal patterns of insulin are decoded by the AKT signaling network, providing both new mechanistic insights and physiological relevance.
Purvis, Jeremy E., Lahav, Galit
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Mekanisme Molekuler Dari Resistensi Insulin Pada Diabetes Melitus Tipe Dua
Majalah Kedokteran Andalas, 2022 Diabetes melitus merupakan kelainan endokrin yang paling sering ditemukan. Salah satu patofisiologi utamanya adalah resistensi jaringan target terhadap insulin.
Eva Decroli
doaj +1 more source
Insulin action at a molecular level – 100 years of progress
Molecular Metabolism, 2021 The discovery of insulin 100 years ago and its application to the treatment of human disease in the years since have marked a major turning point in the history of medicine.
Morris F. White, C. Ronald Kahn
doaj +1 more source
Regulated in development and DNA damage responses -1 (REDD1) protein contributes to insulin signaling pathway in adipocytes. [PDF]
PLoS ONE, 2012 REDD1 (Regulated in development and DNA damage response 1) is a hypoxia and stress response gene and is a negative regulator of mTORC1. Since mTORC1 is involved in the negative feedback loop of insulin signaling, we have studied the role of REDD1 on ...
Claire Regazzetti +5 more
doaj +1 more source
Insulin as an adiposity signal [PDF]
International Journal of Obesity, 2001 Insulin is now well established as an adiposity signal that acts in the brain to influence energy homeostasis. It is secreted in direct proportion to adiposity; it enters the brain from the blood, and it interacts with neurons in the ventral hypothalamus.
S C, Woods, R J, Seeley
openaire +2 more sources
Molecular mechanisms of insulin resistance in chronic liver disease [PDF]
, 2008 The work presented here analyses the role of PP2A in the dysregulation of glucose metabolism in the setting of chronic hepatitis C. We propose a new model for virus induced insulin resistance development through the overexpression of PP2A in the liver ...
Bernsmeier, Christine
core +1 more source