Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes [PDF]
Diabetes, Metabolic Syndrome and Obesity, 2014 Richard WA Mackenzie, Bradley T Elliott Department of Human and Health Sciences, Facility of Science and Technology, University of Westminster, London, UK Abstract: Type 2 diabetes is a metabolic disease categorized primarily by reduced insulin ...
Mackenzie RWA, Elliott BT
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Organ Crosstalk and the Modulation of Insulin Signaling
Cells, 2021 A highly complex network of organ communication plays a key role in regulating metabolic homeostasis, specifically due to the modulation of the insulin signaling machinery. As a paradigm, the role of adipose tissue in organ crosstalk has been extensively
Alejandra Romero, Juergen Eckel
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Cytosolic phospholipase A2 links tau pathology to insulin signaling impairment in Alzheimer’s disease [PDF]
Frontiers in Aging NeuroscienceAlthough impaired insulin signaling in the brain has been recognized as a key factor in the development and progression of Alzheimer’s disease (AD), the underlying mechanisms remain incompletely understood.
Faruk Hossen +4 more
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Insulin signaling engages divergent transcriptional mechanisms in neural and metabolic tissues [PDF]
BMC Molecular and Cell BiologyBackground Insulin signaling is a conserved regulator of growth, metabolism, and lifespan across metazoans. While its systemic roles are well established, the mechanisms by which insulin coordinates tissue-specific transcriptional programs that underlie ...
Roshni Jain +4 more
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Mechanisms and therapeutics of insulin signaling transduction genes in diabetic cardiomyopathy: a comprehensive updated review [PDF]
Frontiers in EndocrinologyDiabetic cardiomyopathy (DCM), a complication of type 2 diabetes mellitus (T2DM), is closely associated with key genes in the insulin signaling pathway.
Yufeng He +6 more
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Higher Plasma Sclerostin and Lower Wnt Signaling Gene Expression in White Adipose Tissue of Prediabetic South Asian Men Compared with White Caucasian Men [PDF]
Diabetes & Metabolism Journal, 2020 BackgroundSouth Asians generally have an unfavourable metabolic phenotype compared with white Caucasians, including central obesity and insulin resistance.
Laura G.M. Janssen +10 more
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E4orf1 Enhances Glucose Uptake Independent of Proximal Insulin Signaling. [PDF]
PLoS ONE, 2016 Impaired proximal insulin signaling is often present in diabetes. Hence, approaches to enhance glucose disposal independent of proximal insulin signaling are desirable. Evidence indicates that Adenovirus-derived E4orf1 protein may offer such an approach.
Ha-Na Na +3 more
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Molecular Metabolism, 2023 Objectives: Insulin's ability to counterbalance catecholamine-induced lipolysis defines insulin action in adipose tissue. Insulin suppresses lipolysis directly at the level of the adipocyte and indirectly through signaling in the brain.
Matthäus Metz +5 more
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Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila. [PDF]
PLoS Genetics, 2013 Reduced insulin/IGF signaling increases lifespan in many animals. To understand how insulin/IGF mediates lifespan in Drosophila, we performed chromatin immunoprecipitation-sequencing analysis with the insulin/IGF regulated transcription factor dFOXO in ...
Hua Bai +3 more
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A genetic strategy to measure insulin signaling regulation and physiology in Drosophila.
PLoS Genetics, 2023 Insulin regulation is a hallmark of health, and impaired insulin signaling promotes metabolic diseases like diabetes mellitus. However, current assays for measuring insulin signaling in all animals remain semi-quantitative and lack the sensitivity ...
Deborah D Tsao +4 more
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